Regulation of spore peptidoglycan modification

NIH Pandemic-Era Grants

Pandemic Era Grants

2024

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Principal Investigator: Aimee  Shen
Organization: TUFTS UNIVERSITY BOSTON
Fiscal Year: 2024
Award: $362,992
Funding agency: National Institute of General Medical Sciences

SUMMARY
The bacterial pathogen, Clostridioides difficile, has been designated an urgent threat to the US healthcare
system by the Centers for Disease Control. In order for C. difficile to initiate infection, its infectious spore form
must germinate in the gut of susceptible individuals. Since spore germination depends on the spore cell wall
undergoing specific modifications, determining how this process occurs in C. difficile could inform the
development of strategies for preventing C. difficile disease transmission and recurrence.

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