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Principal Investigator: CARYN LERMAN
Organization: UNIVERSITY OF SOUTHERN CALIFORNIA
Fiscal Year: 2024
Award: $6,579,621
Funding agency: National Cancer Institute
PROJECT SUMMARY – Overall Component
The USC Norris Comprehensive Cancer Center at the University of Southern California (NCCC) has been
continuously funded as an NCI-designated Comprehensive Cancer Center since 1973. NCCC has a rich tradition
of collaborative research and serves as a major regional and international resource for cancer research,
education, community outreach and engagement, and patient-centered oncology care. Our vision is to reduce
the burden of cancer for all people. A central priority for NCCC is to serve the unique cancer-related needs of
our multicultural catchment area, Los Angeles County (LAC). To achieve this goal, our 187 full members form
collaborative teams and are organized into five impactful Research Programs served by six valuable Shared
Resources (SRs). NCCC’s Cancer Research Training and Education Coordination (CRTEC) programs are part
of the fabric of these efforts, creating a diverse pipeline for the next generation of exceptional cancer scientists
and clinicians. The NCCC Office of Community Outreach and Engagement (COE) is the primary vehicle by which
we understand, engage, and serve the needs of the underserved communities in our catchment area. Our
geographic location in the 4th most diverse city in the nation affords opportunities for NCCC to lead in research
that addresses cancer burdens and disparities among diverse communities and special populations. Indeed,
NCCC is distinguished by exceptional success in recruiting diverse populations to clinical trials, with minorities
accounting for more than 61% of interventional therapeutic accruals. This application requests: 1) support for
five interactive Research Programs; 2) partial support for six SRs and one Developing Preclinical SR that provide
technologies, services, and scientific consultation that will enhance member interaction and productivity; 3)
support for Leadership, Planning, and Evaluation; 4) support for Developmental Funds to foster pursuit of new
priorities, strengthen science, and explore new collaborations and technologies, all aligned with the new NCCC
Strategic Plan; 5) support for Cancer Center Administration; and 6) support centralized scientific oversight
of cancer clinical trials. Members currently hold grants totaling $101.3M (direct costs) with $37.7M from NCI
and have authored landmark publications representing high intra-programmatic (26%), inter-programmatic
(25%) and multi-institutional (45%) cancer research. Continued funding from the Cancer Center Support Grant
(CCSG) will allow us to build on our strengths in basic, population, and clinical sciences, and to facilitate
discovery and its translation into direct benefit to patients and diverse communities.
Terms: <Accounting><Achievement><Achievement Attainment><Address><Applications Grants><Basic Research><Basic Science><Biological Markers><CCSG><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CV-19><California><Cancer Burden><Cancer Center><Cancer Center Support Grant><Cancer Science><Cancers><Caring><Catchment Area><Cell Line><CellLine><Center for Cancer Research><Cities><Clinic><Clinical><Clinical Sciences><Clinical Trials><Collaborations><Communication><Communities><Community Outreach><Comprehensive Cancer Center><Consultations><Coronavirus Infectious Disease 2019><County><Cyclic GMP><Data Science><Decision Making><Detection><Development><Direct Costs><Economically Deprived Population><Education><Education and Outreach><Education and Training><Educational aspects><Enrollment><Ensure><Epidemiology><Evaluation><Fostering><Funding><Generalized Growth><Genome><Genomics><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><Grant><Grant Proposals><Growth><Guanosine Cyclic Monophosphate><Height><Immune mediated therapy><Immunologically Directed Therapy><Immunotherapy><Infrastructure><Institution><Instruction and Outreach><International><Intervention><Intervention Strategies><Intervention Trial><Interventional trial><Investigators><Investments><Laboratories><Lead><Leadership><Los Angeles><Malignant Neoplasms><Malignant Tumor><Minority><Mission><Modeling><Molecular><Monitor><NCI Center for Cancer Research><NIH RFA><National Cancer Burden><Oncology><Oncology Cancer><Patients><Pb element><Peer Review><Persons><Population><Population Heterogeneity><Population Research><Population Sciences><Population-based research><Population-level research><Process><Productivity><Protocol><Protocols documentation><Publications><Request for Applications><Research><Research Personnel><Research Resources><Researchers><Resource Sharing><Resources><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Schools><Science><Scientific Publication><Scientist><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Sight><Socioeconomically disadvantaged><Special Population><Strains Cell Lines><Strategic Planning><Talents><Technology><Textiles><Therapeutic Clinical Trial><Therapeutic Intervention><Tissue Growth><Training><Training Programs><Training and Education><Training and Outreach><Translations><Tutoring and Outreach><Underrepresented Groups><Underrepresented Populations><Universities><Vision><anti-cancer research><bio-markers><biobank><biologic marker><biomarker><biomed informatics><biomedical informatics><biorepository><cGMP><cancer care><cancer clinical trial><cancer disparity><cancer genomics><cancer health disparity><cancer prevention><cancer research><cancer resource><cancer-related health disparity><cohesion><community engagement><consultation><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus infectious disease-19><cultured cell line><developmental><disparity in cancer><diverse populations><economically deprived group><economically deprived people><economically disadvantaged group><economically disadvantaged individual><economically disadvantaged people><economically disadvantaged population><engagement with communities><enroll><epidemiologic><epidemiological><fabric><genomic platform><geographic site><heavy metal Pb><heavy metal lead><heterogeneous population><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><improved><innovate><innovation><innovative><interdisciplinary collaboration><intervention therapy><interventional strategy><life span><lifespan><malignancy><member><mouse model><murine model><neoplasm resource><neoplasm/cancer><next generation><novel><oncogenomics><oncology clinical trial><ontogeny><patient centered><patient oriented><population diversity><pre-clinical><preclinical><programs><recruit><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><socio-economic disadvantage><socio-economically disadvantaged><socio-economically underprivileged><socioeconomic disadvantage><socioeconomically underprivileged><success><survivorship><transdisciplinary collaboration><translation><under representation of groups><under represented groups><under represented people><under represented populations><under served community><underclass><underrepresentation of groups><underrepresented people><underserved community><visual function>