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Principal Investigator: Bei Wu
Organization: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
Fiscal Year: 2024
Award: $679,009
Funding agency: National Institute on Minority Health and Health Disparities
Research Project 3 – NYUCI-ES – Abstract
The physical and emotional demands of dementia caregiving can have enormous negative effects on caregivers’
physical and mental health. Dementia caregivers have increased risk of hypertension and diabetes, compared
to non-caregivers, especially in minority populations. This study will conduct a two-arm randomized controlled
trial to test the efficacy of a culturally tailored version of the NYU Caregiver Intervention (NYUCI) plus enhanced
support (ES) through online chat groups (the NYUCI plus WeChat/Kakaotalk [population social media app for
Chinese/Korean] peer support which we call the NYUCI-ES in reducing health risks for cardiometabolic disease
among older Chinese and Korean-American adults caring for relatives with ADRD. The NYUCI has proven
efficacy in reducing psychological outcomes among largely White samples of caregivers of persons with ADRD
and has been widely replicated and translated in the USA and elsewhere. This study will provide the first large-
scale test of the potential effects of the NYUCI-ES, a multicomponent intervention that includes individual and
family counseling and ongoing support via support group and online chat groups and ad hoc (on demand)
counseling.
In collaboration with community organizations across the New York and northern New Jersey
metropolitan area, we will enroll 300 caregivers of people with ADRD (150 Chinese and 150 Korean) in this
study. Aim 1: Develop culturally adapted informational and educational materials about dementia and caregiving
issues for social service providers of the intervention and for family caregivers. Aim 2: Test the hypothesis, H1:
A counseling and support intervention (the NYUCI-ES) will significantly improve psychosocial factors such as
depression, stress self-rated health and chronic disease management among Chinese and Korean-American
ADRD caregivers and these changes will be mediated by improvement in social support. H1a: By the first (6-
month) follow-up, the mediators (increases in social support, stress reaction) will improve significantly in the
intervention group compared to baseline values and the control group. H1b: These improvements will be
maintained, and lead to reduction in depressive symptoms, and improvement in self-reported health and chronic
disease self-management by the 12-month follow-up compared to the control group. Aim 3: Test the hypothesis,
H2: the NYUCI-ES will reduce biologic risk factors, including metabolic health (glycosylated hemoglobin) and
inflammation (Oxidative stress, lipid metabolism, etc.) within 6 months of enrollment compared to baseline and
a control group; these changes will be mediated through increases in social support and decreases in depressive
symptoms and will be maintained at the 12-month follow-up.
The public health significance of these findings will likely have an impact on health care policy for CGs
from diverse underserved ethnic and cultural backgrounds, potentially reducing morbidity, and improving their
quality of life.
Terms: <2 arm RCT><2 arm randomized control trial><2 arm randomized controlled trial><21+ years old><AD related dementia><ADRD><Active Follow-up><Adult><Adult Human><Alzheimer's and related dementias><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><American><Area><Asian><Asian Americans><Asian group><Asian individual><Asian people><Asian population><Asians><Assay><Belief><Bioassay><Biological><Biological Assay><Blood Sample><Blood specimen><COVID-19><CV-19><Cardiometabolic Disease><Cardiometabolic Disorder><Care Givers><Care giver intervention><Caregivers><Caring><Chinese><Chinese American><Chronic Disease><Chronic Illness><Conflict><Conflict (Psychology)><Control Groups><Coronavirus Infectious Disease 2019><Counseling><Cultural Backgrounds><Dementia><Dementia caregivers><Diabetes Mellitus><Disease Management><Disorder Management><Educational Mainstreaming><Educational Materials><Emotional><Emotional Depression><Enrollment><Ethnic Origin><Ethnicity><Evidence based intervention><Failure><Family><Family Care Giver><Family Caregiver><Glycated Hemoglobins><Glycosylated Hemoglobin><Health><Health Policy><Health Promotion><Hypertension><Individual><Individuals from minority><Individuals of minority><Inflammation><Intake><Intermediary Metabolism><Intervention><Intervention Strategies><Korean American><Koreans><Language><Linguistic><Linguistics><Mainstreaming><Mediating><Mediator><Mental Depression><Mental Health><Mental Hygiene><Metabolic><Metabolic Processes><Metabolism><Minority><Minority Groups><Minority People><Minority Population><Minority individual><Modeling><Morbidity><Morbidity - disease rate><Multilingualism><New Jersey><New York><Nursing Homes><Outcome><Oxidative Stress><Patient Self-Report><Personal Satisfaction><Persons><Physiologic><Physiological><Policies><Population><Psychological Health><Psychosocial Factor><Public Health><QOL><Quality of life><Questionnaires><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Research><Research Grants><Research Project Grants><Research Projects><Risk><Risk Factors><Salutogenesis><Sampling><Self Management><Self-Help Groups><Self-Report><Services><Social isolation><Social support><Stereotyping><Stress><Structure><Support Groups><Testing><Translating><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><achievement Mainstream Education><active followup><adulthood><biologic><biological adaptation to stress><cardiometabolic risk><care giving><care giving outcome><caregiver interventions><caregivers for persons living with dementia><caregivers for persons with dementia><caregivers of individuals with dementia><caregivers of patients with dementia><caregiving><caregiving outcomes><chronic disorder><collaboration with communities><community based organizations><community collaboration><community organizations><community-based collaboration><compare to control><comparison control><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><cultural values><dementia care><dementia care giver><dementia caregiving><depression><depression symptom><depressive><depressive symptoms><diabetes><efficacy testing><enroll><evidence base><fat metabolism><follow up><follow-up><followed up><followup><group intervention><health care policy><health equity><health literacy><healthcare policy><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><interventional strategy><lipid metabolism><metropolitan><multi-component intervention><multi-faceted intervention><multi-modal intervention><multicomponent intervention><multifaceted intervention><multilingual><multimodal intervention><nursing home><older adult><older adulthood><peer support><physical conditioning><physical health><promoting health><provider intervention><psychological outcomes><psychosocial><psychosocial variables><randomisation><randomization><randomly assigned><reaction; crisis><self help organization><social><social media><social service provider><social stigma><social support network><stigma><stress response><stress; reaction><two arm RCT><two arm randomized control trial><two arm randomized controlled trial><under served community><underserved community><well-being><wellbeing>