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Principal Investigator: Alan Tackett
Organization: ARKANSAS CHILDREN'S HOSPITAL RES INST
Fiscal Year: 2022
Award: $770,000
Funding agency: National Institute of General Medical Sciences
Summary
In July of 2017, we launched Phase I of the COBRE Center for Translational Pediatric Research at Arkansas
Children’s Research Institute in Little Rock, Arkansas. The mission of the center is to use proteogenomic
approaches to identify epigenomic mechanisms and therapeutic targets in diseases, including cancer, impacting
or translatable to the pediatric population. The unifying theme of research among center members is utilizing
systems biology approaches and sophisticated bioinformatics for studying disease mechanism. The goal of
Phase I was to establish the foundation of the center, expand the pool of successful investigators with a Faculty
Development Plan, and support systems-level core resources. Towards this goal, the center was created with a
nucleus of 4 Research Project Leaders and 2 research cores, Proteomics Core and Genomics & Bioinformatics
Core. Through use of a mentored Faculty Development Program overseen by the Administrative Core, the junior
investigators from Phase I received 9 RPG-level grants, including an U01-award. Additionally, we were able to
“graduate” both Phase I research cores to self-sustainability. Collectively, during the past 4 years of Phase I, we
have made substantial progress towards establishing a multi-disciplinary, thematic research center through
expansion of our center members, transitioning core resources to independence, and extramural funding –
demonstrating how the center is moving in the direction of long-term sustainability beyond COBRE support.
Building on the momentum of Phase I, our goals in Phase II are to further enhance our institutional research
infrastructure by developing our multi-disciplinary, thematic research center through strategic expansion of the
critical mass of investigators, investing into research infrastructure, and implementing a plan for long-term center
sustainability beyond COBRE support. We will provide structured mentoring and support to an initial group of 5
Research Project Leaders in Phase II. Furthermore, we will expand the pool of investigators in the center through
institutional commitments to recruit 4 Assistant and 1 Associate or Full Professor to the center. To support needs
of the expanding critical mass of investigators, we will develop a new Proteogenomics Core that is essential for
the evolving research mission of the center. This unique core will provide Research Project Leaders and other
center members access to experienced personnel for non-standard proteomic, genomic, and epigenomic
applications, and access to highly skilled bioinformaticians for cutting-edge data analysis and integration. To
support the expansion of investigators and a new research core, the Administrative Core will provide a Faculty
Development Plan, Pilot Project Program, operational oversight, and leadership as the center prepares to
transition to long-term sustainability. Upon completion of Phase II, we anticipate having a critical mass of junior,
mid-career, and senior investigators in the center who have access to world-class systems biology cores, which
will enable center members to successfully compete for individual, multi-investigator, and program-level grants
to support transition of the center to long-term sustainability beyond COBRE support.
Terms: <0-11 years old><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Arkansas><Award><Bio-Informatics><Bioinformatics><Biomedical Research><COBRE><COVID-19 virus><COVID19 virus><Cancers><Cell Nucleus><Center of Biomedical Research Excellence><Centers of Research Excellence><Child><Child Youth><Childhood><Children (0-21)><CoV-2><CoV2><Data Analyses><Data Analysis><Development Plans><Disease><Disorder><EXTMR><Extramural><Extramural Activities><Faculty Education><Faculty Training><Foundations><Funding><Genomics><Goals><Grant><Human Resources><Individual><Institution><Investigators><Leadership><Malignant Neoplasms><Malignant Tumor><Manpower><Mentors><Mission><NIGMS><National Institute of General Medical Sciences><Nucleus><Pediatric Research><Phase><Pilot Projects><Population><Program Development><Proteomics><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Infrastructure><Research Institute><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Support><Researchers><Resources><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Social Support System><Structure><Support System><Systems Biology><Teacher Education><Teacher Educator><Teacher Preparation><Teacher Professional Development><Teacher Training><Variant><Variation><Wuhan coronavirus><associate faculty><associate professor><career><coronavirus disease 2019 virus><coronavirus disease-19 virus><data integration><data interpretation><disease mechanisms study><epigenomics><experience><faculty development><faculty mentor><faculty professional development><full professor><hCoV19><instructor training><malignancy><member><mid-career faculty><midcareer faculty><multidisciplinary><nCoV2><neoplasm/cancer><pediatric><personnel><pilot study><professor><programs><proteogenomics><recruit><senior faculty><service providers><social role><success><teacher development><tenure process><tenure track><therapeutic target><youngster>