Document text
Principal Investigator: Ewan Kemar Cobran
Organization: MAYO CLINIC ARIZONA
Fiscal Year: 2024
Award: $168,264
Funding agency: National Cancer Institute
Project Summary/Abstract
Novel genomic technology, such as microarray analyses and next-generation sequencing, have improved the
understanding of prostate cancer biology and prognosis. The National Comprehensive Cancer Network
(NCCN), in 2016, recommended that patients and clinicians consider tissue-based genetic tests for localized
prostate cancer. However, while much enthusiasm currently exits for the rapidly increasing field of genomic
medicine, the use of multi-gene mRNA expression panels raises the potential for further divergence in prostate
cancer treatment outcomes by race and low socioeconomic status. We know that health disparities persist in
low income groups despite the existence of evidence-based guidelines and that adoption of state-of-the-art
methods often lag behind in these groups.
The goals of this NCI K01 application are to (1) explore how men with localized prostate cancer and their
caregivers comprehend prognostic genetic technology, and (2) examine how an educational video about
genetics impacts patient-caregiver communication of prognostic genetic technology. The study rationale is that
without direct attention to genomic comprehension, the enthusiasm that exists in the rapidly increasing field of
prostate cancer genomic medicine may not translate into health benefits for men with localized prostate
cancer. The central hypotheses are (1) men and caregivers with lower levels of education will demonstrate a
severe lack of genomic comprehension of tissue-based genetic tests for localized prostate cancer; and (2)
tailored prostate cancer education, communication coaching, and a genomic literacy educational video will
significantly improve patient-caregiver communication in a low literacy population.
The study approach is innovative because it applies a mixed-methods community-engagement research
framework to explore how African American and rural White men with localized prostate cancer,
comprehend and interpret data generated from genetic technology. The proposed research is significant
because of its potential to improve public health by (1) improving the understanding of prognostic genetics in
minority, low income, and rural populations, and (2) engage and educate these diverse communities about
genomics. The proposed research, in combination with a structured mentoring and training plan that includes
didactic course and workshops, is designed to facilitate Dr. Ewan Cobran’s long term goal of developing an
independently-funded research program in prostate cancer disparities, consistent with the mission of the
NCI.
Terms: <21+ years old><Address><Adoption><Adult><Adult Human><African American><Afro American><Afroamerican><Alabama><American><Biochemical><Body Tissues><Cancer Biology><Cancer Prognosis><Care Givers><Caregivers><Communication><Communities><Comprehension><Data Analyses><Data Analysis><Death Rate><Diagnosis><Diffusion of Innovation><Disadvantaged><Disparities><Disparity><Education><Educational Achievement><Educational Status><Educational aspects><Educational workshop><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Evidence based practice guidelines><Focus Groups><Funding><Genes><Genetic><Genomic medicine><Genomics><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><Group Interviews><Health Benefit><Health Sciences><Impairment><Incidence><Investments><Knowledge><Literature><Louisiana><Low Income Population><Low Literacy Population><Low income><Low income group><Malignant Tumor of the Prostate><Malignant neoplasm of prostate><Malignant prostatic tumor><Maryland><Mentors><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Methods><Microarray Analysis><Microarray-Based Analysis><Minority><Mission><Mississippi><NCCN><NGS Method><NGS system><NHGRI><NIH><National Center for Human Genome Research><National Comprehensive Cancer Network><National Human Genome Research Institute><National Institutes of Health><Neoplasm Metastasis><North Carolina><Nurses><Participant><Patients><Prognosis><Prostate CA><Prostate CA therapy><Prostate Cancer><Prostate Cancer therapy><Prostate malignancy><Prostatectomy><Prostatic Cancer><Public Health><Race><Races><Radiation><Recommendation><Recurrence><Recurrent><Research><Risk><Rural><Rural Population><Rural group><Rural people><Secondary Neoplasm><Secondary Tumor><South Carolina><Structure><Technology><Time><Tissues><Training><Treatment outcome><United States><United States National Institutes of Health><Virginia><Workshop><adulthood><cancer disparity><cancer education><cancer health disparity><cancer metastasis><cancer-related health disparity><community engaged participatory research><community engaged research><community partnered research><community-engaged study><community-partnered study><data interpretation><design><designing><determine efficacy><directed attention><directs attention><disparity in cancer><disparity in health><educational level><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><ethnic subgroup><ethnicity group><evaluate efficacy><evidence based guidelines><evidence based recommendations><examine efficacy><gene testing><gene-based testing><genetic technology><genetic testing><genome sciences><genomic science><geographic site><health disparity><health literacy><improved><inadequate health literacy><innovate><innovation><innovative><literacy><low SES><low health literacy><low income individual><low income people><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><mRNA Expression><math ability><math achievement><math competence><math competency><math proficiency><mathematic ability><mathematic achievement><mathematic compentence><mathematic compentency><mathematic proficiency><mathematical ability><mathematical achievement><mathematical compentence><mathematical compentency><mathematical proficiency><men><microarray analyses><microarray technology><mortality><mortality rate><mortality ratio><new approaches><next gen sequencing><next generation sequencing><nextgen sequencing><novel><novel approaches><novel strategies><novel strategy><number sense><numeracy><nurse><oncotype><poor health literacy><proficient in math><prognostic><prognostic ability><prognostic power><prognostic utility><prognostic value><programs><prostate cancer treatment><quantitative literacy><racial><racial background><racial origin><randomized control study><randomized, controlled study><reduced health literacy><rural individual><skills><theories><training achievement><training level><training status><treatment planning><tumor cell metastasis>