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Principal Investigator: JUDITH A JAMES
Organization: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Fiscal Year: 2024
Award: $3,999,999
Funding agency: National Institute of General Medical Sciences
The primary mission of the Oklahoma Shared Clinical and Translational Resources (OSCTR) is to improve
health by catalyzing clinical and translational research (CTR) that addresses the top health concerns
experienced in the state. The OSCTR integrates health professionals, investigators, and scientific resources at
more than 30 public, private, and tribal partners statewide to fulfill its mission. Several features make
Oklahoma an ideal setting to continue and expand these efforts, including high rates of chronic diseases and
large rural and tribal populations where improved outcomes may serve as models across IDeA states.
Oklahomans have the sixth lowest life expectancy in the US, with widening disparities for American Indians
and rural populations leading to early mortality. Cancer, diabetes, cardiovascular disease, arthritis, and
autoimmunity are top causes of enhanced morbidity or disability and are exacerbated by high rates of tobacco
and other substance abuse and low rates of routine health screening and healthy life choices. Research on the
health priorities and health equity of our tribal and other underserved populations has been fostered by strong
relationships between research institutions and tribal nations and rural communities. The OSCTR has helped
build a growing and diverse cadre of investigators who have launched independent CTR careers and is broadly
supported by institutional leaders committed to CTR and improving Oklahomans’ health. The OSCTR houses a
highly productive Clinical Resources Core with a CAP-certified biorepository and cutting-edge resources for
clinical data research. Concurrent with these strengths, the OSCTR has leveraged partnerships to build
networks for practice-based research to help speed the adoption of evidence-based practices in patient care.
Despite our successes, the sustainability of CTR research in Oklahoma and its impact on public health are
limited by ongoing needs for infrastructure support and clinical research investigators. To support rural and
tribal health equity, the OSCTR will assist tribal health systems in building CTR infrastructure, foster
interactions via the Tribal Engagement Unit, and expand research with community organizations to address
social determinants of health and increase opportunities for clinical trial participation. We will continue to
support the development of junior investigators from many disciplines by providing training, mentoring, pilot
grants, biostatistics/epidemiology expertise, access to patient samples and clinical data, study recruitment and
regulatory assistance, and comprehensive online resources. We will engage health professionals, communi-
ties, and patients in high-priority CTR through an online portal and existing networks of community-oriented
health improvement organizations. We will continue work with Oklahoma IDeA programs and the national
IDeA-CTR network to develop and share effective infrastructure and increase opportunities for Oklahomans to
participate in cutting-edge research. Together, these activities will grow and sustain a critical mass of investi-
gators and vital infrastructure enhanced by federal funding, industry clinical trials, and other local support.
Terms: <Acceleration><Address><Adoption><Aging><Aliquot><American Indian><American Indian Tribe><American Indians><Area><Arthritis><Autoimmune Status><Autoimmunity><Award><Behavior><Biometrics><Biometry><Biostatistics><COVID test><COVID tests><COVID-19 test><COVID-19 tests><COVID19 test><COVID19 tests><Caliber><Cancers><Cardiovascular Diseases><Cause of Death><Center for Translational Science Activities><Certification><Cessation of life><Child Health><Chronic Disease><Chronic Illness><Clinical><Clinical Data><Clinical Research><Clinical Sciences><Clinical Study><Clinical Trials><Collaborations><Communities><Community Networks><Death><Development><Development Plans><Diabetes Mellitus><Discipline><Disease><Disorder><Disparities><Disparity><Dissemination and Implementation><Epidemiology><Evidence based practice><Eye><Eyeball><Fostering><Foundations><Funding><Goals><Grant><Health><Health Care Professional><Health Priorities><Health Professional><Health system><Healthcare professional><High Prevalence><Individual><Industry><Infrastructure><Institution><Investigators><Leadership><Life><Life Expectancy><Malignant Neoplasms><Malignant Tumor><Mental Health><Mental Hygiene><Mentors><Minority researcher><Mission><Modeling><Morbidity><Morbidity - disease rate><NIH><National Institutes of Health><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Obesity><Oklahoma><Opiates><Opioid><Outcome><Patient Care><Patient Care Delivery><Patients><Physical activity><Population><Practice based research><Privatization><Process><Productivity><Psychological Health><Public Health><RADx Underserved Populations><RADx-UP><Rapid Acceleration in Diagnostics for Underserved Populations><Rapid Acceleration of Diagnostics Underrepresented Persons><Rapid Acceleration of Diagnostics Underserved Populations><Registries><Research><Research Infrastructure><Research Personnel><Research Resources><Researchers><Resources><Risk Reduction><Rural><Rural Community><Rural Health><Rural Population><Rural group><Rural people><SARS-CoV-2 test><SARS-CoV-2 tests><Sampling><Scientist><Sight><Smoking><Speed><Substance abuse problem><Survey Instrument><Surveys><Tobacco><Tobacco Cessation><Tobacco Consumption><Tobacco Use Cessation><Tobacco use><Training><Training and Infrastructure><Translational Research><Translational Research Enterprise><Translational Science><Tribal group><Tribes><Underrepresented Ethnic Minority><Underrepresented Groups><Underrepresented Minority><Underrepresented Populations><Underserved Population><United States National Institutes of Health><Vision><Work><Writing><abuse of substances><adiposity><arthritic><biobank><biorepository><burden of disease><burden of illness><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><care for patients><care of patients><career><caring for patients><catalyst><chronic disorder><clinical data warehouse><clinical practice><community based organizations><community engaged participatory research><community engaged research><community engagement><community organizations><community partnered research><community partnership><community-centered><community-engaged study><community-oriented><community-partnered study><comparative><coronavirus disease 2019 test><coronavirus disease 2019 tests><coronavirus disease test><coronavirus disease tests><coronavirus test><coronavirus tests><corpulence><depository><developmental><diabetes><disability><disease burden><disparity in health><early childhood><engagement with communities><epidemiologic><epidemiological><experience><health disparity><health equity><implementation research><improved><improved outcome><interest><internet portal><internet resource><licit opioid><malignancy><medical college><medical schools><minority investigator><mortality><neoplasm/cancer><nutrition><on-line compendium><on-line portal><on-line resource><online compendium><online portal><online resource><opiate crisis><opiate medication><opiate overdose><opiate related overdose><opioid crisis><opioid drug overdose><opioid epidemic><opioid induced overdose><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><overdose death><overdose fatalities><pandemic effect><pandemic impact><pandemic outcome><pandemic repercussions><practice-based research network><premature><prematurity><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><primary care practice><programs><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><repository><risk-reducing><rural individual><school of medicine><screening><screenings><severe acute respiratory syndrome coronavirus 2 test><severe acute respiratory syndrome coronavirus 2 tests><social health determinants><substance abuse><success><teen birth><test for COVID><tobacco product use><translation research><translation research enterprise><translational investigation><translational research center><translational research program><translational sciences center><tribal Nation><tribal governance><tribal government><tribal health><tribal people><tribal population><tribal self-governance><under representation of groups><under represented groups><under represented people><under represented populations><under served group><under served individual><under served people><under served population><under-representation of minorities><under-represented minority><underrepresentation of groups><underrepresentation of minorities><underrepresented people><underserved group><underserved individual><underserved people><visual function><web portal><web resource><web-based portal><web-based resource>