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Principal Investigator: E Wesley ELY
Organization: VANDERBILT UNIVERSITY MEDICAL CENTER
Fiscal Year: 2020
Award: $868,245
Funding agency: National Institute on Aging
The NIA-funded BRAIN-ICU-2 Study [Bringing to light the Risk factors And Incidence of Neuropsychological
dysfunction (dementia) in ICU Survivors, 2nd Study] will define the relationship between ICU delirium and
dementia. The proposed administrative supplement to BRAIN-ICU-2 Study (R01 AG58639) is in response to
NIA Availability of Administrative Supplements and Revision Supplements on Coronavirus Disease 2019
(COVID-19) (NOT-AG-022; PA-18-591). To understand the brain tissue damage of acute delirium caused by
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), we will perform new neuropathological
studies of critically ill patients affected by COVID-19, as well as those with Alzheimer’s disease and related
dementia (ADRD) with/without critical illness. By studying COVID-19, we will better understand the relationship
between delirium and ADRD. During the current COVID-19 pandemic, intensive care units (ICU’s) across the
nation are awash with patients experiencing delirium, a major ICU risk factor for future ADRD. These delirium
symptoms of impaired consciousness include headache, alteration of gustatory, olfactory, and visual function,
neuropathy, seizures, agitation, encephalitis, and/or Guillain-Barre syndrome. These delirium signs and
symptoms could be due to SARS-CoV-2 infection of the brain, particularly in those with ADRD. We do not
know if there are direct nervous system consequences of COVID-19 (e.g., inflammation), and/or indirect
nervous system consequences, e.g., coagulopathy. To our knowledge, limited autopsy series that included
brain tissue have been published. No information about ADRD was provided. The proposed supplement will
specifically compare multiple groups of patients, ICU patients with/without ADRD with/without COVID-19, along
with non-ICU patients with/without ADRD and with/without COVID-19. The BRAIN-ICU-2 study will provide ICU
patients with/without ADRD with/without COVID-19. The NIA-supported Religious Orders Study (ROS; P30
AG10161, R01 AG15819), and Rush Memory and Aging Project (MAP; R01 AG17917) will provide non-ICU
patients with/without ADRD and with/without COVID-19. The proposed supplement will further build on
collaboration between the Vanderbilt and Rush BRAIN-ICU-2 study teams, and represent the most
comprehensive neuropathologic examination of COVID-19 brains compared to non-COVID-19 brains, in those
with/without ADRD, and with/without critical illness. This supplement will create a unique resource for the
world-wide COVID-19 research community, with a strong and sustained impact on the fields of ICU delirium
and ADRD.
Terms: <2019 novel coronavirus><2019-nCoV><AD dementia><AD related dementia><ADRD><AIDP><Acute><Acute Autoimmune Neuropathy><Acute Infective Polyneuritis><Acute Inflammatory Demyelinating Polyradiculoneuropathy><Acute Inflammatory Polyneuropathy><Acute Inflammatory Polyradiculoneuropathy><Administrative Supplement><Affect><Aging><Agitation><Alzheimer><Alzheimer Type Dementia><Alzheimer disease><Alzheimer related dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Alzheimers disease><Amentia><Autopsy><Blood Coagulation Disorders><Brain><Brain Hemisphere><Brain Inflammation><Brain Nervous System><Brain Stem><Brain region><Brainstem><COVID-19><COVID-19 epidemic><COVID-19 pandemic><COVID19><COVID19 epidemic><COVID19 pandemic><Case Study><Cephalalgia><Cephalgia><Cephalodynia><Cerebral hemisphere><Coagulation Disorder><Coagulopathy><Collaborations><Communities><Conscious><Consciousness><Cranial Pain><Critical Illness><Critically Ill><Degenerative Neurologic Diseases><Degenerative Neurologic Disorders><Delirium><Dementia><Development><Diagnostic Findings><Dysfunction><Encephalitis><Encephalon><Functional disorder><Funding><Future><Grant><Guillain-Barré Syndrome><Guillaine-Barre Syndrome><Head Pain><Headache><Impairment><Incidence><Infection><Inflammation><Intensive Care Units><Landry's paralysis><Landry-Guillain-Barre Syndrome><MR Imaging><MR Tomography><MRI><Magnetic Resonance Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Memory><NMR Imaging><NMR Tomography><National Institute of Aging><National Institute on Aging><Nervous System><Nervous System Degenerative Diseases><Nervous system structure><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Body System><Neurologic Degenerative Conditions><Neurologic Organ System><Neuropathy><Neuropsychologies><Neuropsychology><Nuclear Magnetic Resonance Imaging><P-30 Protein><P30><P30 Protein><Parents><Patients><Physiopathology><Primary Senile Degenerative Dementia><Psychomotor Agitation><Psychomotor Excitement><Psychomotor Hyperactivity><Psychomotor Restlessness><Publishing><Research><Research Resources><Resource Sharing><Resources><Restlessness><Risk Factors><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Seizures><Series><Severe acute respiratory syndrome coronavirus 2><Sight><Signs and Symptoms><Structural defect><Structural malformation><Survivors><Symptoms><Viral><Vision><Wuhan coronavirus><Zeugmatography><acute idiopathic polyneuritis><acute post-infectious polyneuropathy><acute postinfectious polyneuropathy><bleeding disorder><brain tissue><case report><clotting disorder><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019><coronavirus disease 2019 epidemic><coronavirus disease 2019 pandemic><data hub><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><delirious><dementia of the Alzheimer type><depository><developmental><experience><head ache><in vivo><indexing><inflammation marker><inflammatory marker><interest><necropsy><neurodegenerative illness><neuropathic><neuropathology><neuropsychologic><pathophysiology><postmortem><primary degenerative dementia><ranpirnase><religious order study><repository><response><senile dementia of the Alzheimer type><sharing hub><structural abnormalities><structural anomalies><viral RNA><virus RNA><visual function>