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Principal Investigator: Thomas Pohida
Organization: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
Fiscal Year: 2024
Award: $732,263
Funding agency: National Institute of Biomedical Imaging and Bioengineering
The research and development activities of the Instrumentation Development and Engineering Application Solutions (IDEAS) resource are collaborative efforts with NIH Institute scientists that require the development of biomedical laboratory and clinical research systems, instrumentation, and methodologies. The majority of these collaborations require novel approaches and designs for which there are minimal established criteria or technical knowledge. IDEAS staff have in-depth technical experience in all phases of engineering research and development. With their collaborators, IDEAS staff review the clinical and biomedical sciences to formulate project specifications. IDEAS staff evaluate the theoretical and practical constraints, consider commercially available technologies, and finally propose various solutions. IDEAS responsibilities often continue with the hands-on design, implementation, testing, installation, training, documentation, and production of a custom research system or methodology. Current collaborative projects, as well as associated research studies, include:
1. 3D Printed Cover-Slip Holder for Preserving and Protecting Fixed Cells During Shipment
2. 3D Printed Illustrations Renderings for Vision-impaired Visitors of the Cajal Exhibit
3. 3D Printed Intubation Chamber for Studying Histone Binding Proteins
4. 3D Printed PDMS Wafer Mold for Media Diffusion in Time-course Studies
5. 3D Printing Resource Technology Hub
6. 3D-printed Mold to Cast Microarrays for Spheroid Embedding
7. 3D-printed PDMS Molds to Generate Microvessel Platforms
8. Adaptor to Hold a 10X Genomics GEM-Generation Chip in Place for Single Cell Sorting
9. Adjustable Inclined Plane for Evaluation of Pediatric Exoskeleton Control Modes
10. Agarose Molding Stamp for High-Throughput Zebrafish Imaging
11. Analytical Ultracentrifugation for Protein Assembly Dynamics
12. AR Scientific Data Visualization
13. Artificial Tick Feeding Chamber
14. Assessing the Value of 18F-NaF PET-CT to Predict Calcium Content
15. Automated Functional Mapping of Somatosensation
16. Automated Readout of Behaviors in Freely-moving Macaques
17. Automation of Alcohol Vapor Chambers for Continued Air Supply
18. Behavior Box Mouse Whisker Monitoring for Neuronal Circuit Studies
19. BETA Center
20. Biomechanical Coupling of Skull and Brain for Magnetic Resonance Elastography Experiments
21. Bioreactor for Long-Term Culture of Cerebral Organoids
22. Bone Growth Plate Cartilage Pellet Culture Bioreactor
23. Cell Segmentation for Real-Time Measurement of Intracellular Oxygenation Concentration
24. Characterization of the Nociception Phenotype in Individuals with Intellectual Disability
25. Characterizing Spontaneous Movements in Mouse Pups
26. Conductive Polymer based Microelectroporation for High Efficiency Cell Transfection
27. Controlled Testing Platform of Blood Flow Patterns
28. Correlating MRI and Histopathology Using Patient-specific Prostate Mold
29. CUP Water Treatment Testing Apparatus
30. Custom Cannula for Pressure Myography of Mice Blood Vessels
31. Custom Cover for Treating Cells with Light Inside a Multi-Welled Plate
32. Custom Microplates for CellInsight Imager
33. Data Acquisition System for Multi-channel Imaging System
34. Development of a Handheld Optical Spectroscopy System
35. Diffusion Exchange Functional MRI
36. Direct Time of Flight PET Scanner
37. Dish with a Grid Pattern of Reservoirs to Hold Zebrafish Larvae for Imaging
38. Disinfectant-compatible Storage Solutions for Clinical Equipment
39. Distortion Product Otoacoustic Emissions System
40. Enrichment Device for Animal Behavior Experiments
41. EPR Imaging of in vivo Oxygen Status Associated with Cancer Treatment Studies
42. Evaluation of Extracellular Matrix Stiffness Around Tumor Using Atomic Force Microscopy
43. Fabrication of a 3D Printed Coverslip Sample Holder for Traction Force Microscopy Experiments
44. Fabrication of a 3D-printed Ovary Dissection Mold for Gonadal Tissue Histological Study
45. Fixed-Head Mouse Whisker Monitoring for Neuronal Circuit Studies
46. Glymphatics MRI Phantom Development
47. Ground Squirrel Hibernation Automated Behavior Monitoring
48. High-throughput Video-based Assessment of Drosophila - Drug Efficacy
49. Homebased Biosensor for Monitoring COVID-19 Patients
50. Hydrogel-Like Applicator for Treating Surface Cancer on Organs with Complex Topologies
51. Imaging/Interrogation of Metastatic Colonization in Perfused Resected Liver
52. Improved Mosquito Housing Device to Evaluate Consequences of Pyrethroid Resistance Mechanisms on Aedes Aegypti Dengue Infections
53. Improved TUR Device
54. Incubation Chamber for Brain Tissue
55. Incubator for Optogenetic Applications
56. Instrumentation for Spinal Learning Studies
57. Laser Welder GMP for Hyperpolarized MRI
58. Light-sheet Microscopy of Drosophila Motor Neuronal Circuits
59. Liver Perfusion System
60. Low-cost Shoe Design for Pediatric Patients with Lower Extremity Impairments
61. Macaque Brain Mold for Histology
62. Machine vision enabled behavioral tracking for cross-species extrapolation
63. Microfluidic PNA-based HIV Detection
64. Mirror Neuron Network Dysfunction as an Early Biomarker of Neurodevelopmental Disorder
65. Modifying a PCR Instrument Cooling Plate to Fit a 1536-Well Plate
66. Mouse Cardiac Electrophysiology Recording System
67. Mouse Home-Cage Monitoring Device for Learning and Memory
68. Mouse Illumination System for Retinal Dystrophy Studies
69. Mouse Whisker Stimulation and Tracking During Neural Imaging Experiments
70. MRI Elastography for Anisotropic Materials
71. Multi-Animal FED Operant Device
72. Multiview Light Sheet Imaging of Centimeter Scale Cleared Tissue Samples
73. Noninvasive Multispectral Imaging to Quantitatively Assess Tissue Vasculature
74. OCT - Adaptive Optics Retinal Imaging with Eye Tracking
75. Open-Source Reader for At-Home COVID Tests
76. Placenta Real-time Oximetry Using Ultrasound and NIR Spectroscopy
77. Portable Low-Field Magnetic Resonance Imager
78. Precise Cell Injection System to Model Immune Cell Recruitment and Engagement with Tumor Cells in Peritoneum Tissue
79. PRiME - Cardiovascular Intervention
80. Prostate Tumor Fresh Tissue Guided Procurement Methods
81. Quantitative Evaluation of Dynamic Activity of HeLa Cells in Different Viability States Using Dynamic Full-field Optical Coherence Microscopy
82. Rapidscan CW EPR Imaging of Oxygen Status
83. Refactoring an existing LabVIEW software application for iPALM
84. Running Wheel Tachometer
85. SCORHE - Phenotyping and Behavioral Assays
86. Signal Amplification by Reversible Exchange
87. Single-Cell Analysis of Rare Virus-Infected and Tumor Cells by FIND-Seq
88. SLO - Adaptive Optics Retinal Imaging with Eye Tracking
89. Take-home Device for Handgrip Strength Measurements
90. Tenodesis Type Action Hand Prosthesis for Pediatric Rehabilitation
91. Therapeutic EMFs to Reduce Cell Growth in Glioblastoma Multiforme
92. Tissue Characterization and Oxygenation Measurement
93. Tissue Culture Matrix Casting for Spheroid Growth and Histology
94. Tissue Freezing Cassette
95. Tissue Vacutainer Device
96. UV Crosslinking Device to Accurately Map Incorporated 4SU RNA-protein Interactions
97. Vessel Mimetics for Cancer Cell Culture
98. Vestibular Sensory Evoked Potentials System
99. Video Analysis System for Behavior and Activity Assessment of Fruit-Flies in High-Throughput Studies
100. Video Monitoring System for Automated Detection of Pain Related Mice Behaviors
101. Video System for Mouse Visual Response Identification
102. Wearable Optical Platform for Assessment of Hemodynamic Changes
103. Whisker holder fixture for Local Field Potential recordings
104. X-clometer - New Radiographic Marker
105. Zebrafish Intubation Chamber for Longitudinal Imaging
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Electrophysiological Diagnostics><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cartilage><Cartilaginous Tissue><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cell-Extracellular Matrix><Cells><Cells Placenta-Tissue><Cellular Expansion><Cellular Growth><Cerebrum><Childhood><Citellus><Clinic><Clinical><Clinical Research><Clinical Study><Collaborations><Communication><Complex><Computer Software Development><Computer Software Engineering><Computer software><Computers><Coupling><Culicidae><Custom><DENV infection><Danio rerio><Dengue Infection><Dengue virus infection><Detection><Development><Development and Research><Devices><Diffusion><Disinfectants><Dissection><Documentation><Drosophila><Drosophila genus><ECM><Electronics><Encephalon><Engineering><Epiphyseal Plate><Epiphysial cartilage><Equipment><Evaluation><Evoked 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transduction><biomechanical><biophysical foundation><biophysical principles><biophysical sciences><body movement><brain lymph system><brain lymphatic system><brain tissue><business-friendly environment><cancer cell><cancer therapy><cancer-directed therapy><cardiac electrophysiology><cell culture><cell cultures><cell fixing><cell growth><cell sorting><cerebral><child patients><circulatory system><collaborative atmosphere><collaborative environment><coronavirus disease 2019 infected patient><coronavirus disease 2019 monitoring><coronavirus disease 2019 patient><coronavirus disease 2019 positive patient><coronavirus disease 2019 test><coronavirus disease 2019 tests><coronavirus disease infected patient><coronavirus disease monitoring><coronavirus disease patient><coronavirus disease positive patient><coronavirus disease test><coronavirus disease tests><coronavirus disease-19 patient><coronavirus patient><coronavirus test><coronavirus tests><cost><cranium><crosslink><customs><data 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studies><histological studies><histone-binding proteins><homes><imager><imaging><imaging system><improved><in vivo><innovate><innovation><innovative><instrument><instrumentation><intellectual and developmental disability><interactive atmosphere><interactive environment><interdisciplinary atmosphere><interdisciplinary environment><interventional strategy><limited intellectual functioning><longitudinal imaging><m-Health app><m-Health application><mHealth app><mHealth application><machine based learning><machine vision><magnetic field><malignancy><mechanic><mechanical><microbioreactor><mimetics><mirror neuron><monitoring device><motoneuron><neoplasm/cancer><neoplastic cell><network dysfunction><neural imaging><neuro-imaging><neurodevelopmental disease><neuroimaging><neurological imaging><neuronal circuit><neuronal circuitry><new approaches><nociceptive><novel><novel approaches><novel strategies><novel strategy><ontogeny><open source><optical><optogenetics><otoacoustic emission><paravascular system><patient infected with COVID><patient infected with COVID-19><patient infected with SARS-CoV-2><patient infected with coronavirus disease><patient infected with coronavirus disease 2019><patient infected with severe acute respiratory syndrome coronavirus 2><patient with COVID><patient with COVID-19><patient with COVID19><patient with SARS-CoV-2><patient with coronavirus disease><patient with coronavirus disease 2019><patient with severe acute respiratory distress syndrome coronavirus 2><pediatric><pediatric patients><peer-group atmosphere><peer-group environment><polymer><polymeric><portability><positron emission computed tomography><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><precision medicine><precision-based medicine><preservation><pressure><printed circuit board><prosthetic hand><prototype><pup><pyrethroid><radio frequency><radiofrequency><radiologic imaging><radiological 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