Document text
Principal Investigator: Brent L Berwin
Organization: JACKSON LABORATORY
Fiscal Year: 2024
Award: $213,164
Funding agency: National Cancer Institute
PROJECT SUMMARY/ABSTRACT
The goal of the annual Jackson Laboratory Short Course on Experimental Models of Human Cancer is to train
graduate students, postdocs, and junior investigators in the basic science and application of experimental models
of human cancer. The training program will immerse participants and faculty in a unique and highly integrated
scientific environment and empower the next generation of scientists tackling human cancer. The integrated
program will cover advances in three critical areas: experimental cancer models, modern technology to assess
mechanisms and outcomes, and the interplay of the tumor and host genetics as well as tumor microenvironment
and the immune system. It will teach classical approaches to mouse and human genetics, modern molecular
genetic methodologies, computational and bioinformatics concepts, ontological standards, and scientific and
medical ethics. Trainees will participate in lectures, workshops, multi-disciplinary scientific debates, networking
and career development sessions, and poster sessions. They will receive practical training in bioinformatics,
statistical genetics, and the use and analysis of PDX models. This course will take place at The Jackson
Laboratory (JAX), which hosts an NCI-designated Basic Laboratory Cancer Center and is a global resource of
mouse models. The proposed 8-day intensive, immersion course focused on graduate students, postdocs, and
new investigators will promote active interaction and networking between the participants as well as with the
outstanding cadre of lecturers and trainers. Additionally, the Short Course will be delivered in a hybrid format,
with online/virtual access to the seminars and, where practical and feasible, the workshops: this was successfully
piloted in 2022. The hybrid format enhances inclusivity by reducing barriers to participation for individuals who
could not otherwise attend. JAX is deeply committed to training a diverse group of biomedical scientists and we
will continue to promote diversity in both the recruitment of participants and in the tools being generated to study
cancer. Diverse attendees will be actively recruited, scholarships will be provided to enable in-person
attendance, and an inclusive virtual option will enable participation by those that are unable to travel. Diversity
will also be emphasized in the context of best practices for cancer research to address ongoing health care
disparities, the need for studies of genetically diverse models, and representation of diverse backgrounds within
genetic databases and samples.
Terms: <Acceleration><Active Learning><Address><Area><Basic Research><Basic Science><Bio-Informatics><Bioinformatics><Biologic Models><Biological Models><Cancer Biology><Cancer Center><Cancer Model><Cancer Treatment><CancerModel><Cancers><Cell Body><Cell Line><CellLine><Cells><Clinical><Clinical Research><Clinical Study><Complex><Cooperative Learning><Curriculum><Development><Disease><Disorder><Education><Education and Training><Educational Curriculum><Educational aspects><Educational process of instructing><Educational workshop><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Evaluation><Experiential Learning><Experimental Designs><Experimental Models><Faculty><Funding><Future><Generations><Genetic><Genetic Alteration><Genetic Change><Genetic Data Banks><Genetic Data Bases><Genetic Databanks><Genetic Databases><Genetic Information Databases><Genetic defect><Genomics><Goals><Grant><Human><Human Genetics><Hybrids><Immersion><Immune><Immune response><Immune system><Immunes><Immunological response><Individual><Interdisciplinary Research><Interdisciplinary Study><Investigators><Knowledge><Laboratories><Learning><Link><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mammalian Genetics><Medical><Medical Ethics><Medical Oncologist><Methodology><Mice><Mice Mammals><Minority><Model System><Modeling><Modern Man><Modernization><Molecular><Molecular Genetics><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Mutation><Oncology><Oncology Cancer><Ontology><Organoids><Outcome><PDX model><Participant><Pathogenesis><Pathway interactions><Patient Recruitments><Patient derived xenograft><Patients><Persons><Postdoc><Postdoctoral Fellow><Recruitment Activity><Research><Research Associate><Research Personnel><Research Resources><Researchers><Resources><Sampling><Scholarship><Scientist><Sight><Strains Cell Lines><Study models><Survey Instrument><Surveys><Teaching><Techniques><Technology><Testing><The Jackson Laboratory><Therapeutic><Training><Training Programs><Training and Education><Travel><Tumor Cell><Update><Vision><Workshop><active recruitment><analytical tool><anti-cancer><anti-cancer research><anti-cancer therapy><biomedical scientist><cancer genomics><cancer immunology><cancer microenvironment><cancer research><cancer therapy><cancer-directed therapy><career><career development><career fair><career networking><cultured cell line><design><designing><developmental><disadvantaged background><disparity in care><disparity in healthcare><empowerment><epigenetically><experience><flexibility><flexible><genetic approach><genetic strategy><genome mutation><graduate student><health care disparity><health care inequality><health care inequity><healthcare disparity><healthcare inequality><healthcare inequity><host response><human model><immune system response><immunoresponse><improved><lecturer><lectures><lesson plans><malignancy><marginalized background><meeting><meetings><model of human><mouse genetics><mouse model><multidisciplinary><murine model><neoplasm immunology><neoplasm/cancer><neoplastic cell><next generation><oncogenomics><participant recruitment><pathway><patient derived xenograft model><post-doc><post-doctoral><post-doctoral trainee><posters><professional networking><programs><recruit><research associates><research study><resistance to therapy><resistant to therapy><skills><speed networking><synergism><therapeutic resistance><therapy resistant><tool><treatment resistance><tumor><tumor immunology><tumor microenvironment><virtual><visual function>