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Principal Investigator: Jason M Nagata
Organization: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Fiscal Year: 2024
Award: $173,910
Funding agency: National Heart Lung and Blood Institute
PROJECT SUMMARY / ABSTRACT
Cardiovascular disease (CVD) is the leading cause of death in the United States and physical activity is a potent
way to decrease this risk. Serious gaps remain in our understanding of the optimal duration of physical activity
and sedentary behavior during adolescence and young adulthood if risk for concurrent and future CVD is to be
averted, and were specifically identified as priority research areas in the 2018 Department of Health and Human
Services (HHS) Physical Activity Guidelines for Americans. Adolescence and young adulthood are critical
transition periods that set physical activity patterns for the rest of adulthood and may represent a critical window
for early intervention. The overall objective of this K08 is to develop evidence to bridge the HHS-articulated gaps
by describing independent effects of sedentary behavior in adolescence and thresholds of physical activity in
young adulthood on the prevention of later-life CVD to inform future HHS guidelines. The central hypothesis is
that highly sedentary adolescents and young adults will require higher physical activity levels to reduce CVD risk
in later adulthood. This project will analyze longitudinal cohort data from the Adolescent Brain Cognitive
Development (ABCD) Study, the National Longitudinal Study of Adolescent to Adult Health (Add Health), and
the Coronary Artery Risk Development in Young Adults (CARDIA) Study. The Specific Aims will: (1) determine
independent associations of contemporary forms of sedentary behavior (screen time) in adolescents with CVD
risk factor incidence; (2) evaluate associations of attaining HHS-recommended adolescent (60 mins/day, 7
days/week) versus adult (30 mins/day, 5 days/week) physical activity levels during specific age ranges in young
adulthood with incidence of CVD risk factors; and (3) estimate population-level lifetime effects of adolescent and
young adult sedentary behaviors, physical activity dose, and their interactions on later-life CVD mortality. The
candidate’s long-term career objective is to become an independent physician-epidemiologist generating
actionable evidence to optimize adolescent and young adult behaviors to prevent CVD later in life. The proposed
career development plan will provide training and mentorship in: (1) physical activity, sedentary behavior, and
CVD epidemiology and measurement; (2) longitudinal analyses and modeling methods; (3) guideline
development and implementation; and (4) career development and plan for independence. Training will be
achieved through coursework, seminars, tutorials, conferences, hands-on experience, and active mentoring. The
mentoring team includes nationally recognized experts in cardiovascular epidemiology, adolescent and young
adult medicine, physical activity/sedentary behavior, biostatistics, guideline development, and implementation
science. Completion of this K08 will inform specific guidance for adolescents and young adults in the next edition
of the Physical Activity Guidelines for Americans. The K08 will support a future R01 grant using implementation
science and modeling approaches to promote attainment of national physical activity guidelines to prevent CVD,
aligned with NHLBI’s strategic vision of reducing heart disease through data and implementation science.
Terms: <12-20 years old><21+ years old><Accounting><Add Health><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult><Adult Human><Age><American><Apoplexy><Area><Articulation><Behavior><Biometrics><Biometry><Biostatistics><Brain><Brain Nervous System><Brain Vascular Accident><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cardiac Diseases><Cardiac Disorders><Cardiac infarction><Cardiovascular Diseases><Cause of Death><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cessation of life><Clinical Trials><Coronary Artery Risk Development in Young Adults><Coronary Artery Risk Development in Young Adults Study><Data><Data Science><Death><Department of Health and Human Services><Development><Development Plans><Diabetes Mellitus><Diminished Vision><Dose><Early Intervention><Encephalon><Epidemiologist><Event><Exposure to><Future><Grant><Growth and Development><Growth and Development function><Guidelines><Health><Health Benefit><Heart Diseases><Human><Hyperlipemia><Hyperlipidemia><Hypertension><Incidence><Intervention><Intervention Strategies><Knowledge><Life><Link><Long-term cohort><Longitudinal Studies><Longitudinal cohort><Longterm cohort><Low Vision><Measurement><Medicine><Mentors><Mentorship><Methods><Modeling><Modern Man><Modification><Myocardial Infarct><Myocardial Infarction><NHLBI><National Heart, Lung, and Blood Institute><National Longitudinal Study of Adolescent Health><National Longitudinal Survey of Adolescent to Adult Health><Partial Sight><Pattern><Physical activity><Physicians><Population><Premature Mortality><Prevention><Public Health><Recommendation><Reduced Vision><Research Priority><Resource Allocation><Rest><Risk><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sedentary behavior><Sedentary life-style><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Specific qualifier value><Specified><Strategic vision><Stroke><Subnormal Vision><Testing><Text Messaging><Time><Training><United States><United States Department of Health and Human Services><United States Dept. of Health and Human Services><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Video Games><Visual impairment><adolescence (12-20)><adult youth><adulthood><age associated><age correlated><age dependent><age group><age linked><age related><age specific><ages><analyzing longitudinal><brain attack><cardiac infarct><cardiovascular disease epidemiology><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder epidemiology><cardiovascular disorder risk><cardiovascular epidemiology><career><career development><cerebral vascular accident><cerebrovascular accident><cognitive development><cohort><conference><convention><coronary attack><coronary infarct><coronary infarction><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><developmental><diabetes><evidence base><experience><heart attack><heart disorder><heart infarct><heart infarction><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><implementation science><interventional strategy><juvenile><juvenile human><lack of physical activity><late life><long-term study><longitudinal analysis><longitudinal outcome studies><longterm study><markov model><meeting><meetings><mortality><physical inactivity><prevent><preventing><screen time><sedentary><sedentary lifestyle><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><short message service><skills><social media><stroked><strokes><summit><symposia><symposium><television watching><texting><tv watching><video call><video calling><video chat><video phone call><videogame><vision impairment><visually impaired><young adult><young adulthood>