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Principal Investigator: Joshua Levy
Organization: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
Fiscal Year: 2024
Award: $1,415,699
Funding agency: National Institute on Deafness and Other Communication Disorders
The goals of the Sinonasal and Olfaction program are to address unmet needs for improved patient care in smell, taste and inflammatory sinus disease. We lead mechanistic, translational and clinical studies that address one of two primary focus areas. 1) Sinonasal inflammation and its impact on olfaction and 2) central neurologic processing of olfactory signals in health and disease. These efforts are supported by active clinical protocols and the collection of observational clinical data along with matched tissue samples to support clinically relevant studies that have the potential to impact patient care.
In the past year we have continued to establish clinical protocols and studies to address the above aims.
Clinical Protocols:
NIDCD Data and Specimens (IRB 001126) has been amended to allow for the collection of sinonasal tissues and olfactory epithelium from healthy volunteers and study participants. Both tissues, along with nasal lining fluid and brush collections of epithelial cells, are used to study sinonasal disease and causes of disrupted olfaction.
Smell and Taste Center Survey (IRB002219) has been established to study the knowledge attitudes and practices of patients, clinicians and researchers with an interest in smell and taste.
MADREP (IRB001928) is established to evaluate participants with combined sinus and airway disease. Examples include Aspirin-exacerbated respiratory disease (AERD), Allergic Fungal Sinusitis (AFRS), nasal polyposis, hypereosinophilic syndrome, and many others. Participants will be seen in a combined clinic with otolaryngology (NIDCD) and immunology (NIAID) providers.
IN the next year the following protocols will be completed
Natural History of Smell and Taste Loss, a longitudinal protocol allowing for further study of the central and peripheral mechanisms of chemosensory disorders. Participants will be seen in a weekly clinic at the Clinical Center.
Research Studies:
Prostaglandin E2 (PGE2) expression in AFRS. This study is the first to identify increased PGE2 expression in recalcitrant sinonasal disease. This work identifies a new therapeutic and disgnosit target with the potential to impact patient care. These findings have resulted in several honors, including recognition as a Fellow in the American Laryngological, Rhinological and Otologic (Triologic) Society, and an Honor Award for Basic Research. Findings are expected to be presented at the 2025 Triologic Combined Sections Annual Meeting. Manuscript is currently under review with a prominant Otolaryngology Journal.
Clinical Practice Guideline: Immunotherapy for Inhalant Allergy. This establishes multi-specialty recommendations for improved patient care and the management of inhalant allergy.
Comparison of RT-PCR and Antigen Test Sensitivity Across Nasopharyngeal, Nares, and Oropharyngeal Swab, and Saliva Sample Types during the SARS-CoV-2 Omicron Variant. This study evaluates relative SARS-CoV-2 viral loads across the upper airway. The study provides additional evidence to support recommended sampling methods for COVID screening.
Impact of sinonasal surgery and irrigation technique on delivery to the olfactory epithelium. These two studies add clinical evidence to support best practices in medical and surgical treatment for patients with olfactory dysfunction in the setting of chronic sinusitis.
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