Document text
Principal Investigator: Minolfa C Prieto
Organization: GORDON RESEARCH CONFERENCES
Fiscal Year: 2022
Award: $40,000
Funding agency: National Heart Lung and Blood Institute
PROJECT SUMMARY
The renin angiotensin aldosterone system (RAAS) is a key regulator of cardiovascular (CV) function, fluid
electrolyte balance, and homeostasis, and it influences many systems including the renal, neuroendocrine, and
immune systems. Perturbations of the RAAS trigger a cascade of events, including generation of vasoactive
mediators, oxidative stress, inflammatory responses, and tissue remodeling, thus contributing to end-organ
pathology and disease. In the 2022 GRC on Ang, we will discuss the most recent, cutting-edge discoveries in
the field and share insights on emerging new areas beyond the CV system such as the role of the RAAS in
adipose biology, bone marrow regulation, liver function, neurocognition, and immune responses. The
conference will focus on the latest advances of the RAAS from discovery science to clinical impact. A highlight
in 2022 will be the celebration of 22 years of the discovery of ACE2. ACE2 is a multifunctional protein, that not
only is CV protective by generating Ang-(1-7) and Ang-(1-9) from Ang II and Ang I respectively, but it is also,
tissue injurious by acting as the receptor for the SARS-CoV-2, the etiologic agent of the current worldwide
COVID-19 pandemic. The enigmas of ACE2 as a key enzyme in the protective arm of the RAAS will be a
highlight. The role of ACE2 as a major mediator and potential therapeutic target in COVID-19 will be debated
along with the controversies on the progression of COVID-19 infection and long-term outcomes in populations
treated with ACE inhibitors and/or angiotensin receptor blockers. The 2022 GRC on Ang will further feature
novel topics including sex-differences in the regulation and changes of the RAAS during the life course (fetal
programming, kidney development, and aging) will be further addressed. In line with precision medicine being
the next frontier in clinical medicine, the meeting will also highlight new advances in the pharmacogenomics,
proteomics, and metabolomics of the RAAS in human diseases. Preceding the GRC, we will have the 2022
Gordon Research Seminar (GRS), a special forum for graduate students, postdoctoral fellows, early career
researchers and other junior scientists to present and exchange new data and cutting-edge ideas. The 2022
GRS will focus on recent advances in RAAS studies beyond the classical paradigms, including new functions
of receptors from this system and providing trainees with an enhanced understanding of current tools to aid
their research, and cover a wide range of topics including the immune system, sex differences and aging.
Additionally, the mentorship sessions will address the interplay between academia and industry and discuss
approaches to translate scientific discoveries to the clinic and how to optimize impact. The aims are aligned
with the NHLBI, NIDDK and NIAID missions and initiative and the scientific themes that will be covered are of
direct relevance to these institutes. NIH funds requested will help attract young investigators and trainees,
including from underrepresented groups with limited opportunities to joint top national and international experts
in the RAAS for networking among researchers, clinicians, young investigators and trainees.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><ACE Inhibitors><ACE2><Academia><Address><Adipose tissue><Aging><Ang I (1-7)><AngII><Angiotensin I><Angiotensin I-Converting Enzyme Inhibitors><Angiotensin II><Angiotensin Receptor><Angiotensin-Converting Enzyme Antagonists><Angiotensin-Converting Enzyme Inhibitors><Angiotensins><Anniversary><Area><Autoregulation><Award><Basic Research><Basic Science><Biology><Blood Diseases><Blood Pressure><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 infection><COVID-19 pandemic><COVID-19 public health crisis><COVID-19 virus><COVID19><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 infection><COVID19 pandemic><COVID19 public health crisis><COVID19 virus><CV-19><CV19><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Causality><Clinic><Clinical><Clinical Medical Sciences><Clinical Medicine><Clinical Sciences><CoV-2><CoV2><Collaborations><Data><Development><Diabetes Mellitus><Differences between sexes><Differs between sexes><Digestive Diseases><Digestive System Diseases><Digestive System Disorders><Disease><Disorder><Doctor of Medicine><Doctor of Philosophy><Electrolyte Balance><Electrolytes><Endocrine Diseases><Endocrine Diseases and Manifestations><Endocrine System Diseases><Enzyme Gene><Enzymes><Etiology><Event><Fatty Tissue><Fostering><Funding><Future><GI tract disorder><Gender><Generations><Goals><Health><Health Sciences><Heart Vascular><Hematologic Diseases><Hematological Disease><Hematological Disorder><Homeostasis><Human Biology><Hypertension><Immune response><Immune system><Immunological response><Industry><Inflammatory Response><Institutes><International><Investigators><Joints><Kidney><Kidney Diseases><Kidney Urinary System><Kininase II Antagonists><Kininase II Inhibitors><Lead><Leadership><Life Cycle><Life Cycle Stages><Liquid substance><M.D.><Mediator><Mediator of Activation><Mediator of activation protein><Medical Research><Mentors><Mentorship><Metabolic Diseases><Metabolic Disorder><Minority Groups><Minority People><Minority Population><Minority individual><Mission><NHLBI><NIAID><NIDDK><NIH><National Heart, Lung, and Blood Institute><National Institute of Allergy and Infectious Disease><National Institute of Diabetes and Digestive and Kidney Diseases><National Institutes of Health><Nephropathy><Neurocognition><Neuroendocrine><Neuroendocrine System><Neurosecretory Systems><Nutrition Disorders><Nutritional Disorders><Obesity><Organ><Outcome><Oxidative Stress><Pathologic Processes><Pathological Processes><Pathology><Pb element><Persons><Ph.D.><PhD><Pharmacogenomics><Physiological Homeostasis><Population><Postdoc><Postdoctoral Fellow><Productivity><Proteins><Proteomics><Public Health><QOL><Quality of life><Receptor Protein><Regulation><Renal Disease><Renin-Angiotensin-Aldosterone System><Research><Research Associate><Research Personnel><Research Training><Researchers><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 infection><SARS-CoV-2 pandemic><SARS-CoV2><SARS-CoV2 epidemic><SARS-CoV2 infection><SARS-CoV2 pandemic><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Science><Scientist><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome related corona virus 2><Sex Differences><Sexual differences><System><Therapeutic><Thesaurismosis><Tissues><Translating><Translational Research><Translational Science><Travel><Underrepresented Ethnic Minority><Underrepresented Groups><Underrepresented Minority><Underrepresented Populations><United Kingdom><United States National Institutes of Health><Universities><Urinary Tract Diseases><Urologic Diseases><Urologic Disorder><Urological Diseases><Urological Disorders><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Virginia><Woman><Women Physicians><Wuhan coronavirus><adipose><adiposity><allergic/immunologic body system><allergic/immunologic organ system><angiotensin I (1-7)><angiotensin converting enzyme 2><angiotensin converting enzyme II><angiotensin-(1-7)><arm><base><blood disorder><cardiovascular disorder><cardiovascular function><career><career development><causation><circulatory system><conference><convention><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 infection><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 virus><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 virus><coronavirus infectious disease-19><corpulence><design><designing><developmental><diabetes><digestive disorder><digestive tract disease><disease causation><endocrine disorder><fetal programming><fluid><frontier><gastrointestinal tract disease><gastrointestinal tract disorder><graduate student><hCoV19><heavy metal Pb><heavy metal lead><high blood pressure><host response><human disease><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune system response><immunoresponse><improved><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><insight><kidney development><kidney disorder><life course><liquid><liver function><meetings><metabolism disorder><metabolism measurement><metabolomics><metabonomics><minority student><nCoV2><nephrogenesis><novel><post-doc><post-doctoral><precision medicine><precision-based medicine><programs><receptor><receptor function><renal><renal disorder><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sex-dependent differences><sex-related differences><sex-specific differences><social role><success><summit><symposia><symposium><systems research><therapeutic target><tool><translation research><under representation of groups><under represented groups><under represented people><under represented populations><under-representation of minorities><under-represented minority><undergrad><undergraduate><undergraduate student><underrepresentation of groups><underrepresentation of minorities><underrepresented people><urinary tract disorder><white adipose tissue><yellow adipose tissue>