Signaling and Biotechology Program
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Principal Investigator: Hui-Kuan Lin Organization: WAKE FOREST UNIVERSITY HEALTH SCIENCES Fiscal Year: 2019 Award: $93,518 Funding agency: National Cancer Institute The major goals of the newly formed Signaling and Biotechnology (SBT) Program are to understand the mechanisms underlying cancer pathogenesis and resistance to therapy and to use this knowledge to develop new technologies leading to more effective strategies for improved detection and treatment of cancer. The SBT program combines a range of disciplines (signaling biology and therapeutics, engineering, clinical medicine, and physical sciences) with the goal of increasing basic knowledge and developing innovative technologies for research, diagnosis, and treatment of cancer. We focus on difficult-to-treat cancers and those with high incidence and mortality in the Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) catchment area. Terms: <3-D><3-Dimensional><3D><Ab response><Abscission><Address><Agonist><Animal Model><Animal Models and Related Studies><Antibodies><Antibody Formation><Antibody Production><Architecture><Area><Ascites><Automobile Driving><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Baptist Church><Baptists><Basic Cancer Research><Bio-Informatics><Biochemical><Bioinformatics><Biological><Biological Function><Biological Process><Biology><Biometrics><Biometry><Biophysics><Biostatistics><Biotech><Biotechnology><Blood Precursor Cell><Body Tissues><Brain Metastasis><Breast Cancer therapy><Breast Neoplasms><Breast Tumors><C Type Lectin Receptors><CCSG><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CHD7><CHD7 gene><Cancer Center Support Grant><Cancer Detection><Cancer Genes><Cancer Treatment><Cancer-Promoting Gene><Cancers><Carbonate hydro-lyase><Carbonic Anhydrases><Carcinomatosis><Catchment Area><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Lineage><Cell Signaling><Cells><Certification><Chromodomain Helicase DNA-Binding Protein 7><Clinic><Clinical><Clinical Medical Sciences><Clinical Medicine><Clinical Research><Clinical Study><Clinical Trials><Collaborations><Communication><Complex><Comprehensive Cancer Center><Computer Models><Computer Simulation><Computer based Simulation><Computerized Models><Contrast Agent><Contrast Drugs><Contrast Media><Cristobalite><DMBA><DNA Damage><DNA Damage Repair><DNA Injury><DNA Repair><Detection><Development><Devices><Diagnosis><Discipline><Disease><Disease Progression><Disorder><Dose><Drug Kinetics><Drug resistance><Drugs><Effectiveness><Effector Cell><Electromagnetic Fields><Electromagnetic Fields Radiation><Engineering><Engineering / Architecture><Environment><European><Excision><Extirpation><FOLH><FOLH1><FOLH1 gene><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Cytometry Shared Resource><Flow Microfluorimetry><Flow Microfluorometry><Folate Hydrolase 1><GCP2><Generalized Growth><Genetic Screening><Glutamate Carboxypeptidase II><Goals><Growth><Guidelines><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Hemoglobin><Hepatocarcinoma><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Heterogeneity><High Throughput Assay><Human><Hypoxia><Hypoxic><Hypoxic tumor><Image><Imaging Device><Imaging Instrument><Imaging Tool><Immune><Immune system><Immunes><In Vitro><Incidence><Induction Therapy><Institutes><Intracellular Communication and Signaling><Investigators><KIAA1416><Knowledge><Laboratories><Link><Lipid A><Liver Cells Carcinoma><Liver X Receptor><Local Cancer><Localized Cancer><Localized Malignancy><Localized Malignant Neoplasm><Malignant Cell><Malignant Melanoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Prostate><Malignant neoplasm of abdomen><Malignant neoplasm of prostate><Malignant prostatic tumor><Mammary Cancer><Mammary Neoplasms><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Math Models><Mathematical Model Simulation><Mathematical Models and Simulations><Measurement><Measures><Mechanics><Mediating><Medical><Medical Device><Medication><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Brain><Metastatic Tumor><Metastatic Tumor to the Brain><Metastatic malignant neoplasm to brain><Methodology><Mice><Mice Mammals><Micro RNA><MicroRNAs><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Mitochondrial Proteins><Modality><Modeling><Modern Man><Molecular Tumor Suppression><Monitor><Murine><Mus><N-Acetylated Alpha-Linked Acidic Dipeptidase 1><NAALAD1><NAALADase I><NEOADJ><Nature><Neoadjuvant><Neoadjuvant Therapy><Neoadjuvant Treatment><Neoplasm Metastasis><Network Analysis><New Agents><Non-Malignant><Non-Polyadenylated RNA><Oncogenes><Oncogenesis><Operating Rooms><Operative Procedures><Operative Surgical Procedures><Organ><Organoids><Oxygen Deficiency><P53><PINK1><PINK1 gene><PSM><PSMA><Pancreas Neoplasms><Pancreas Tumor><Pancreatic Tumor><Pathogenesis><Pathway Analysis><Pathway interactions><Patients><Peritoneal><Pharmaceutic Preparations><Pharmaceutical Preparations><Pharmacokinetics><Phase><Primary carcinoma of the liver cells><Progenitor Cells><Prostate CA><Prostate Cancer><Prostate-Specific Membrane Antigen><Prostatic Cancer><Proteins><Proteomics><Protocol><Protocols documentation><RNA><RNA Gene Products><Radiation Surgery><Radiopaque Media><Radiosurgery><Refractory><Regenerative Medicine><Regulation><Removal><Reporting><Reproduction><Research><Research Personnel><Researchers><Resistance><Resolution><Resource Sharing><Retinoic Acid Receptor><Review Committee><Ribonucleic Acid><Risk><Role><Sampling><Sand><Saturated Fatty Acids><Secondary Neoplasm><Secondary Tumor><Seminal><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Silica><Silicon Dioxide><Stem cells><Stereotactic External Beam Irradiation><Stereotactic Radiosurgery><Stereotaxic Radiosurgery><Sterotactic External Beam Radiation><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T4 Cells><T4 Lymphocytes><TLR protein><TM-MKR><TNBC><TNF Receptor-Associated Factor 6 Gene><TP53><TP53 gene><TRAF6><TRAF6 gene><TRP53><Technology><Testing><Th-1 Cell><Th1 Cells><The Sun><Therapeutic><Therapeutic Intervention><Time><Tissue Growth><Tissues><Tn antigen><Toll-Like Receptor Family Gene><Toll-like receptors><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcriptional Activator><Transcriptional Activator/Coactivator><Transcriptional Coactivator><Transforming Genes><Transgenic Mice><Translating><Treatment Efficacy><Trehalose><Tridymite><Tumor Antigens><Tumor Cell><Tumor Markers><Tumor Oxygenation><Tumor Pathology><Tumor Protein p53 Gene><Tumor Suppression><Tumor Tissue><Tumor-Associated Antigen><Type 1 Helper Cell><Ubiquitilation><Ubiquitination><Ubiquitinoylation><United States><Unscheduled DNA Synthesis><Work><abdominal cancer><abdominal dropsy><allergic/immunologic body system><allergic/immunologic organ system><anti-cancer immunotherapy><anti-cancer therapy><antibody biosynthesis><anticancer immunotherapy><anticancer therapy><aptamer><base><biological signal transduction><biophysical foundation><biophysical principles><biophysical sciences><blood stem cell><cancer antigens><cancer cell><cancer diagnosis><cancer immunotherapy><cancer initiation><cancer metastasis><cancer microenvironment><cancer progression><cancer therapy><carbonate dehydratase><castration resistant prostate cancer><cell culture><cell engineering><cell imaging><cell killing><cellular engineering><cellular imaging><clinical translation><computational modeling><computational models><computational simulation><computational tools><computer based models><computerized modeling><computerized simulation><computerized tools><customized therapy><customized treatment><deep learning algorithm><develop therapy><developmental><diagnostic biomarker><diagnostic marker><dimethylbenz(a)anthracene><dimethylbenzanthracene><driving><drug resistant><drug/agent><electromagnetic field><epigenetic regulation><exosome><extracellular><flow cytophotometry><forest><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><high throughput screening><human disease><hydroperitonia><hydrops abdominis><image-based method><imaging><imaging method><imaging modality><immune check point><immune checkpoint><immunecheckpoint><immunoglobulin biosynthesis><immunotherapy for cancer><immunotherapy of cancer><improved><in silico><in vivo><individualized medicine><individualized patient treatment><individualized therapy><individualized treatment><innovate><innovation><innovative><innovative technologies><insight><instrument><interest><intervention development><intervention efficacy><intervention therapy><liver carcinoma><malignancy><mammary tumor><mathematic model><mathematical model><mathematical modeling><mechanical><melanoma><member><metabolism measurement><metabolomics><metabonomics><miRNA><miRNAs><microfluidic chip><mitochondrial autophagy><model of animal><model organism><mortality><mouse model><multidisciplinary><murine model><nano particle><nano pore><nano-sized particle><nanoparticle><nanopore><nanosized particle><neoplasm immunology><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><neural><new diagnostics><new drug treatments><new drugs><new technology><new therapeutics><new therapy><next generation diagnostics><next generation therapeutics><non-invasive imaging><noninvasive imaging><nonmalignant><novel><novel diagnostics><novel drug treatments><novel drugs><novel technologies><novel therapeutics><novel therapy><ontogeny><optoacoustic tomography><overexpress><overexpression><p53 Genes><pancreatic neoplasia><pancreatic neoplasm><particle><pathway><patient response><peritoneal dropsy><peritoneal exudate><pharmacokinetic model><photoacoustic tomography><physical science><placental stem cell><pre-clinical><preclinical><programs><prostate cancer cell><prostate cancer progression><prostate tumor cell><protein kinase BRPK gene><radio frequency><radio-surgery><radiofrequency><relating to nervous system><resection><resistance to Drug><resistance to therapy><resistant><resistant to Drug><resistant to therapy><response><response to treatment><responsive patient><senescence><senescent><small molecule inhibitor><social role><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based treatment><sun><surgery><tailored medical treatment><tailored therapy><tailored treatment><theranostics><therapeutic efficacy><therapeutic resistance><therapeutic response><therapeutic target><therapeutically effective><therapy development><therapy efficacy><therapy resistant><thymus derived lymphocyte><transcription co-activator><transcriptional co-activator><treatment development><treatment resistance><treatment response><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor><tumor biomarker><tumor cell metastasis><tumor growth><tumor hypoxia><tumor immunology><tumor microenvironment><tumor progression><tumor specific biomarker><tumor specificity><tumor-specific antigen><tumorigenesis><ubiquination><ubiquitin conjugation><unique treatment><uptake><virtual simulation>