Document text
Principal Investigator: PETER L FRANZEN
Organization: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Fiscal Year: 2024
Award: $776,721
Funding agency: National Institute of Mental Health
ABSTRACT
Suicide is the second leading cause of death among young people age 14–24, and rates in this age group are
increasing. Most suicide risk factors are distal (i.e., long-standing, static), thus informative regarding who is at
risk, but not when. As such, our ability to reliably predict near-term suicide risk among vulnerable populations
remains grossly inadequate.
Studies consistently demonstrate a link between subjective sleep disturbances and the continuum of suicidality.
Yet, sleep is a complex behavior that can be measured along multiple dimensions and at varying levels of
analysis. Furthermore, little attention has been paid to the role of normative biological and psychosocial
developmental processes that further contribute to dynamic changes in risk related to sleep disturbance. Such
changes in sleep are particularly dramatic during adolescence. Studies also have not examined how sleep
interacts with other known pathways, such as dysregulation in affective, cognitive and arousal-related systems,
to lead to suicidality in vulnerable youth.
We thus propose to conduct an 8-week prospective multi-method study of sleep health and suicidal thoughts
and behavior in a transdiagnostic sample of ultra-high risk adolescents (14-18) who have recently enrolled in an
Intensive Outpatient or Partial Hospitalization Program. We will capitalize on the extant clinical and research
infrastructures to compare sleep-suicide associations and plausible affective, cognitive and arousal-related
mechanisms using self-report, behavioral, lab task paradigms and physiology in adolescents at ultra-high risk
for suicide.
Terms: <12-20 years old><Adolescence><Adolescent><Adolescent Youth><Affect><Affective><Age><American><Arousal><Attention><Behavior><Behavioral><Behavioral inhibition><Biological><Cardiac><Cause of Death><Cell Phone><Cellular Phone><Cellular Telephone><Clinic><Clinical><Cognitive><Complex><Data><Data Reporting><Day Care><Development><Developmental Process><Diagnostic><Dimensions><Distal><ECG><EKG><Electrocardiogram><Electrocardiography><Emotional><Enrollment><Event><Feeling suicidal><Frequencies><Gender><Impairment><Impulsivity><Intervention><Intervention Strategies><Learning><Link><Long-term prospective studies><Longterm prospective studies><Machine Learning><Measures><Mediating><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Methods><Mobile Phones><Modeling><Modification><Moods><Out-patients><Outpatients><Partial Hospitalization><Participant><Pathway interactions><Patient Self-Report><Pattern><Persons><Physiology><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Process><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychopathology><Public Health><RDoC><Regulation><Reporting><Research><Research Domain Criteria><Research Infrastructure><Rewards><Risk><Risk Assessment><Risk Factors><Role><Sampling><Self-Report><Shapes><Sleep><Sleep Disorders><Sleep disturbances><Suicidal thoughts><Suicide><Suicide attempt><System><Task Performances><Techniques><Time><Treatment Day Care><Vulnerable Populations><Work><Youth><Youth 10-21><aberrant sleep><abnormal psychology><actigraph><actigraphy><adolescence (12-20)><age associated effects><age effect><age group><age related effects><ages><aging effect><behavioral impairment><biologic><biopsychosocial><clinical infrastructure><cognitive control><cost><data representation><data representations><design><designing><developmental><diaries><disrupted sleep><disturbed sleep><enroll><fatal attempt><fatal suicide><heart rate variability><high risk><high risk group><high risk individual><high risk people><high risk population><high-risk adolescents><iPhone><impact of age><impaired behavior><impaired sleep><improved><influence of age><innovate><innovation><innovative><intent to die><interventional strategy><irregular sleep><juvenile><juvenile human><longitudinal, prospective study><machine based learning><malleable risk><mental illness><modifiable risk><mood symptom><non fatal attempt><nonfatal attempt><outpatient programs><outpatient services><pathway><poor sleep><programs><prospective><psychiatric illness><psychological disorder><psychosocial><quality of sleep><sleep behavior><sleep control><sleep diseases><sleep disruption><sleep dysfunction><sleep dysregulation><sleep habit><sleep health><sleep hygiene><sleep illness><sleep problem><sleep quality><sleep regulation><smart phone><smartphone><social role><substance use><substance using><suicidal><suicidal attempt><suicidal behavior><suicidal ideation><suicidal risk><suicidal thinking><suicidality><suicide behavior><suicide ideation><suicide risk><suicides><thoughts about suicide><vulnerable group><vulnerable individual><vulnerable people>