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Principal Investigator: Wei Gao
Organization: CALIFORNIA INSTITUTE OF TECHNOLOGY
Fiscal Year: 2024
Award: $398,730
Funding agency: National Heart Lung and Blood Institute
PROJECT SUMMARY
Metabolic syndrome is on the rise as the leading cause of morbidity and mortality, affecting more than a third
of all U.S. adults. If untreated, patients who develop type 2 diabetes mellitus (T2D) are at high-risk for major
adverse cardiovascular events, including stroke, myocardial infarction, and cardiovascular related deaths.
Despite chronic screening and monitoring for patient-specific prediction and prevention for cardiometabolic
disease, there remains a bottleneck to detect and monitor the metabolic risk factors underlying the rising
epidemic of obesity-associated with hyperlipidemia, hypertension, and diabetes. For these reasons,
developing wearable molecular sensors, which allow for seamless screening, monitoring, and potentially
enables timely intervention, is clinically significant to confront the rising endemic of cardiometabolic disorders.
In this project, we propose to continuously monitor a panel of key metabolic biomarkers including glucose,
uric acid, branched-chain amino acids (BCAAs: leucine, isoleucine, and valine), and insulin using an
integrated Molecular Sensing System (iMSS). We hypothesize that seamless detection of cardiometabolic
biomarkers accelerates our capacity to identify metabolic risk factors in our prediabetic patients with obesity
for early nutrition intervention to reduce health disparities in the U.S. In addition to integrating with our existing
glucose and uric acid sensors, we propose to develop novel laser-engraved wearable sensors for continuous
monitoring of BCAAs and insulin based on a novel nanobiosensing approach that combines high-throughput
laser-fabricated graphene, molecular imprinting based ‘artificial antibody’, and in situ sensor regeneration
technique. This approach will enable large-scale, low-cost fabrication of highly sensitive and selective sensors
for continuous monitoring of clinical meaningful cardiometabolic analytes in human sweat at ultralow
concentrations (such as BCAAs). The use of laser-induced microfluidics and numerical simulation-guided
design optimization enables efficient fluid sampling with minimized effects from the sensing delay and fluid
evaporation. Harnessing the power of concurrent multiplexed cardiometabolic sensing, adjusted
electrochemical measurements based on pH, electrolytes, temperature, and sweat rate calibration minimize
the systematic uncertainties persisted in the current generation of wearable sensing systems. We will validate
the correlation of the sweat/blood biomarkers in healthy subjects using the iMSS and deploy these epidermal
sensors to the high-risk patients. We envision that the iMSS system will provide an entry point to identify pre-
diabetes and obesity at risk for conversion to T2D, and will have translational significance to mitigate clinical
manifestation of major adverse cardiovascular events.
Terms: <21+ years old><Acceleration><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><Antibodies><Apoplexy><Biological Markers><Biosensing Technics><Biosensing Techniques><Biotech><Biotechnology><Blood><Blood Reticuloendothelial System><Brain Vascular Accident><Branched-Chain Amino Acids><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Calibration><Cardiac infarction><Cardiology><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cessation of life><Chemistry><Chronic><Clinical><Clinical Nutrition><Collaborations><Cystic Fibrosis><D-Glucose><Death><Decrease health disparities><Detection><Dextrose><Diabetes Mellitus><Diagnosis><Dietary Intervention><Disease><Disorder><Electrolytes><Engineering><Engravings><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Fatty Liver><Generations><Genetic><Glucose><Goals><Gold><Gout><Health disparity mitigation><Health disparity reduction><Heart Vascular><Home><Human><Humulin R><Hyperlipemia><Hyperlipidemia><Hypertension><IRB><IRBs><In Situ><Institutional Review Boards><Insulin><Intervention><Intervention Strategies><Isoleucine><Joints><K element><Ketosis-Resistant Diabetes Mellitus><L-Valine><Laser Electromagnetic><Laser Radiation><Lasers><Leucine><Liquid substance><Liver Steatosis><Lower health disparities><Maturity-Onset Diabetes Mellitus><Measurement><Medicine><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic syndrome><Methods><Microfluidics><Mitigate health disparities><Modern Man><Molecular><Monitor><Morbidity><Morbidity - disease rate><Mucoviscidosis><Myocardial Infarct><Myocardial Infarction><NIDDM><Natural regeneration><Nature><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Non-Invasive Detection><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Noninvasive Detection><Novolin R><Nutrition Interventions><Nutritional Interventions><Obesity><Obesity Epidemic><Pathogenesis><Patient Monitoring><Patients><Physical activity><Physiologic><Physiologic Monitoring><Physiological><Physiological Monitoring><Population><Potassium><Prediabetes><Prediabetes syndrome><Prediabetic State><Prevention><Protocol><Protocols documentation><Publications><Reduce health disparities><Regeneration><Regular Insulin><Research><Risk><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Scientific Publication><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Stroke><System><T2 DM><T2D><T2DM><Techniques><Temperature><Testing><Thesaurismosis><Trioxopurine><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Uncertainty><Uric Acid><Valine><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><adiposity><adult onset diabetes><adulthood><bio-markers><biologic marker><biomarker><biosensing><body sensor><body worn sensor><brain attack><branched amino acids><cardiac infarct><cardiometabolic><cardiometabolic risk><cardiometabolism><cerebral vascular accident><cerebrovascular accident><circulatory system><clinical relevance><clinical significance><clinically relevant><clinically significant><coronary attack><coronary infarct><coronary infarction><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><corpulence><design><designing><diabetes><diet intervention><doubt><epigenetically><evaporation><fabrication cost><fluid><graphene><heart attack><heart infarct><heart infarction><hepatic steatosis><hepatosteatosis><high blood pressure><high risk><homes><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><imprint><interventional strategy><ischemic cardiomyopathy><ketosis resistant diabetes><liquid><manufacturing cost><maturity onset diabetes><metabolism disorder><mortality><nano><nano engineering><nanoengineering><non-invasive monitor><noninvasive monitor><novel><nutrition><obese individuals><obese patients><obese people><obese person><obese population><obese subjects><patients with obesity><personalized health care><personalized healthcare><pre-diabetes><pre-diabetic><precision health care><precision healthcare><prediabetic><regenerate><remote screening><screening><screenings><sensor><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><simulation><stroked><strokes><temporal measurement><temporal resolution><time measurement><type 2 DM><type II DM><type two diabetes><wearable><wearable biosensor><wearable device><wearable electronics><wearable sensor><wearable sensor technology><wearable system><wearable technology><wearable tool><wearables><wireless><wireless monitor><wireless sensor><µfluidic>