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Principal Investigator: AMIT KHANDHAR
Organization: PAI LIFE SCIENCES, INC.
Fiscal Year: 2019
Award: $299,184
Funding agency: National Institute of Allergy and Infectious Diseases
Effective Targeted Delivery of RNA-based Vaccines and Therapeutics: RNA-based vaccines and therapeutics have emerged as great promise for HIV prevention and treatment, respectively. However, many obstacles still need to be overcome, in particular RNA instability, manufacturing problems, and clinically relevant delivery mechanisms of RNA into target cells. The primary objective is to develop improved platform technologies for the delivery of RNA into specific cells and tissues to improve the efficacy of HIV vaccines or therapeutics. To enhance the efficacy of traditional HIV vaccines and therapeutics, combinations of cytokines, adjuvants, broadly neutralizing monoclonal antibodies, immune checkpoint inhibitors, etc. can also be co-delivered in mRNA form.
Terms: <0-11 years old><AIDS prevention><Adjuvant><Blood Serum><Body Tissues><Cell Body><Cells><Checkpoint inhibitor><Child><Child Youth><Children (0-21)><Domestic Rabbit><Female><General Viruses><Glycoproteins><HIV Prevention><HIV vaccine><HIV-1><HIV-1 vaccine><HIV-I><HIV/AIDS Vaccines><HIV/AIDS prevention><HIV1><HIV1 vaccine><Human Immunodeficiency Virus Type 1><Human immunodeficiency virus 1><Immune checkpoint inhibitor><In Vitro><Lead><Lipids><Messenger RNA><Modeling><Mothers><Nanostructures><Non-Polyadenylated RNA><Oryctolagus cuniculus><Pb element><RNA><RNA Gene Products><RNA Instability><RNA amplification><RNA vaccine><Rabbits><Rabbits Mammals><Replication Unit><Replicon><Ribonucleic Acid><Sampling><Serum><Technology><Therapeutic><Tissues><Transfection><Vaccination><Vaccines><Virus><base><children><childrens'><clinical relevance><clinically relevant><cytokine><heavy metal Pb><heavy metal lead><human immunodeficiency virus vaccine><immune check point inhibitor><improved><mRNA><mRNA vaccine><nano particle><nano-sized particle><nano-structures><nanoparticle><nanosized particle><neonate><neutralizing antibody><neutralizing mAb><neutralizing monoclonal antibodies><novel><pregnant><site targeted delivery><targeted delivery><youngster>