Document text
Principal Investigator: Marta Filizola
Organization: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Fiscal Year: 2020
Award: $169,420
Funding agency: National Institute on Drug Abuse
PROJECT SUMMARY
The coronavirus disease 2019 (COVID-19) pandemic that originated in Wuhan, China just a few months ago is
advancing at an incredible rate in the United States and the rest of the world. It is impacting everyone's lives,
as well as crippling the global economy, health care systems, and more. The disease is caused by the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pathogen, and it appears to exert its most
devastating effects on people's respiratory and pulmonary systems although recent reports have also cited
cardiac complications in otherwise healthy individuals. Based on analyzed data from confirmed cases in the
United States between February 12th and March 28th, the Centers
for
Disease
Control
and
Prevention
disclosed that people with substance use disorders such as those with histories of smoking, as well as those
with diabetes, chronic lung disease, and heart disease may be at increased risk of developing severe
complications from COVID-19. Considering the prevalence of these health conditions in the United States, the
global COVID-19 cases approaching 1 million at the time of this writing, the alarming COVID-19 projections for
the month of April, the likelihood that COVID-19 becomes seasonal, and the fast pace at which SARS-CoV
pathogens evolve into forms with higher cross-species transmission and/or higher affinity for human receptors,
there
doctors
against
against
is no doubt that the scientific world must mobilize to offer as many solutions as possible to help medical
and health care providers save lives. Among these solutions, are suggestions for new medications
COVID-19, considering repurposed or may not prove effective
COVID-19. against
drugs in clinical trials may
In this application, we propose to expand the range of potential medications
that currently
COVID-19 using a rational, structure-based drug discovery approach focused on the virus-receptor recognition
mechanism, which regulates its infection, pathogenesis, and host range.
Terms: <2019 novel coronavirus><2019-nCoV><Affect><Affinity><Angiotensin Converting Enzyme><Angiotensin I-Converting Enzyme><Animals><Anti-Malarials><Antimalarial Agents><Antimalarial Drugs><Antimalarials><Antiviral Agents><Antiviral Drugs><Antivirals><Assay><Binding><Bioassay><Biologic Assays><Biological Assay><CD143 Antigens><CDC><COVID-19><COVID-19 epidemic><COVID-19 pandemic><COVID19><COVID19 epidemic><COVID19 pandemic><Carboxycathepsin><Cardiac><Cardiac Diseases><Cardiac Disorders><Catalogs><Cell Body><Cells><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Chemicals><China><Chlorochin><Chloroquine><Chronic lung disease><Clinical Trials><Collaborations><Complement><Complement Proteins><Complex><Computer Assisted><Coronaviridae><Coronavirus><Crystallization><Data Analyses><Data Analysis><Data Set><Dataset><Diabetes Mellitus><Dipeptidyl Peptidase A><Disease><Disease Outbreaks><Disorder><Drug Interactions><Drugs><Engineering><Ensure><FDA approved><Future><GS-5734><Goals><HIV Protease Inhibitors><Health><Health Care Providers><Health Care Systems><Health Personnel><Healthcare Providers><Healthcare Systems><Healthcare worker><Heart Diseases><Human><Hydroxychlorochin><Hydroxychloroquine><Immune><Immunes><Individual><Infection><Investigation><Khingamin><Kininase A><Kininase II><Laboratories><Lead><Letters><Life><Lung><Lung Respiratory System><Mainland China><Mediating><Medical><Medication><Modeling><Modern Man><Molecular Interaction><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Outbreaks><Oxychlorochin><Oxychloroquine><Pathogenesis><Pb element><Peptidyl-Dipeptidase A><Pharmaceutic Preparations><Pharmaceutical Preparations><Pneumonia><Population><Prevalence><Proteins><Pulmonary Body System><Pulmonary Organ System><Receptor Protein><Reporting><Research><Research Priority><Respiratory System><Respiratory Tracts><Respiratory tract structure><Rest><Risk><Ritonavir><SARS><SARS Virus><SARS corona virus><SARS coronavirus><SARS coronavirus disease><SARS-Associated Coronavirus><SARS-CoV><SARS-CoV disease><SARS-CoV-2><SARS-CoV2><SARS-Related Coronavirus><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Severe Acute Respiratory Syndrome><Severe Acute Respiratory Syndrome CoV disease><Severe Acute Respiratory Syndrome Virus><Severe Acute Respiratory Syndrome corona virus><Severe Acute Respiratory Syndrome coronavirus><Severe Acute Respiratory Syndrome coronavirus disease><Severe acute respiratory syndrome coronavirus 2><Smoking History><Societies><Structure><Structure-Activity Relationship><Substance Use Disorder><Substance of Abuse><Suggestion><Surface><System><Testing><Therapeutic><Time><TimeLine><Treatment Efficacy><Uncertainty><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Viral Diseases><Viral Receptor><Virus><Virus Diseases><Virus Receptors><Writing><Wuhan coronavirus><Yasmin><anti-malarial agents><anti-malarial drugs><anti-viral agents><anti-viral drugs><anti-virals><base><chemical structure function><combat><computer aided><corona virus><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019><coronavirus disease 2019 epidemic><coronavirus disease 2019 pandemic><cross-species spillover><cross-species transmission><data interpretation><diabetes><doubt><drug candidate><drug discovery><drug/agent><economic impact><experiment><experimental research><experimental study><health care personnel><health care worker><health provider><health workforce><healthcare personnel><heart disorder><heavy metal Pb><heavy metal lead><host jump><host switching><in silico><interspecies transmission><intervention efficacy><medical personnel><meth abuse><methamphetamine abuse><norvir><novel><opiate abuse><opiate consumption><opiate drug abuse><opiate drug use><opiate intake><opiate use><opioid abuse><opioid consumption><opioid drug abuse><opioid drug use><opioid intake><opioid use><pandemic><pandemic disease><pathogen><prevent><preventing><pulmonary><receptor><receptor binding><receptor bound><remdesivir><respiratory><response><screening><severe acute respiratory syndrome-CoV><small molecule><structure function relationship><substances of abuse><therapeutic efficacy><therapeutically effective><therapy efficacy><tissue culture><transmission across species><transmission between species><transmitted across species><transmitted between species><transmitted cross-species><treatment provider><vaping><viral infection><virtual screening><virtual screenings><virus infection><virus-induced disease>