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Principal Investigator: ELIZABETH W KARLSON
Organization: BRIGHAM AND WOMEN'S HOSPITAL
Fiscal Year: 2024
Award: $339,909
Funding agency: National Institute of Arthritis and Musculoskeletal and Skin Diseases
PROJECT SUMMARY/ABSTRACT – Resource Core 1: Human Biosamples Core
Obtaining fresh, carefully phenotyped human samples is the most daunting logistical hurdle facing the Joint
Biology Consortium (JBC) Research Community. The Human Biosamples Core overcomes this barrier with a
“systems solution” that integrates existing resources at the Brigham and Women’s Hospital (BWH), Boston
Children’s Hospital (BCH), and affiliated institutions with a bioinformatically-sophisticated team of personnel to
support sample identification, patient recruitment, sample processing, data management, and statistical
analysis. Unique strengths include an extraordinary range of patient samples, both pediatric and adult; core
leadership with expertise in cutting-edge translational research, biobanking, and electronic health record (EHR)
interrogation; bioinformatics and biostatistics; and access to healthy controls as well as patients with
comparator diseases. This mission will be realized through two Specific Aims.
Aim I helps JBC members identify and obtain relevant archived biosamples from 16 different established
sources, ranging from >120,000 patients in the Mass General Brigham (MGB) Biobank to highly specialized
collections from common and rare rheumatic diseases as well as relevant controls. Examples include registries
of rheumatoid arthritis (BRASS), psoriatic arthritis (COPPAR), and systemic lupus erythematosus (SYLVER);
juvenile-onset rheumatic disease biobanks at BCH and CARRA; checkpoint inhibitor-induced rheumatic
diseases; and synovial tissue from the Amsterdam Arthritis Bank as well as local archives.
Aim II provides targeted, prospective recruitment via the JBC Recruitment Core, through which a dedicated
team identifies, contacts, consents, obtains, and processes samples from patients meeting JBC member
specifications. Donors include >120,000 MGB Biobank patients, including >45,000 with genotype data, BWH
and BCH rheumatology clinics, ongoing clinical trials, and other sources.
Led by expert rheumatoid arthritis investigator and methodologist Dr. Elizabeth Karlson, supported by
associate directors Dr. Jeffrey Sparks at BWH, Dr. Lauren Henderson at BCH, and Dr. Deepak Rao heading
the BWH Human Immunology Center for sample processing, the Human Biosamples Core represents a unified
biospecimen pipeline to accelerate hypothesis-driven research into inflammatory arthritis and related diseases
for investigators across the multicenter JBC network.
Terms: <0-11 years old><21+ years old><Acceleration><Adolescent><Adolescent Youth><Adult><Adult Human><Archives><Arthritis><Atrophic Arthritis><Bio-Informatics><Bioinformatics><Biology><Biometrics><Biometry><Biopsy><Biostatistics><Blood><Blood Reticuloendothelial System><Body Fluids><Body Tissues><Boston><COVID infected patient><COVID patient><COVID positive patient><COVID-19><COVID-19 infected patient><COVID-19 patient><COVID-19 positive patient><COVID19 patient><COVID19 positive patient><CV-19><Cancer Patient><Cell Body><Cells><Checkpoint inhibitor><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Clinic><Clinical Trials><Collection><Communities><Complex><Consent><Coronavirus Infectious Disease 2019><Data><Data Set><Dedications><Development><Disease><Disorder><Electronic Health Record><Faculty><Genotype><Health><Hospitals><Human><Human Resources><IRB><IRBs><Immune checkpoint inhibitor><Immunology><Inflammatory Arthritis><Infrastructure><Institution><Institutional Review Boards><Investigators><Joints><Leadership><Link><Lupus><Lupus Erythematosus Disseminatus><Manpower><Medicine><Mission><Modern Man><Musculoskeletal Pain Disorder><On-Line Systems><Online Systems><Oranges><Patient Recruitments><Patients><Pediatric Hospitals><Phenotype><Position><Positioning Attribute><Process><Prospective Studies><Protocol><Protocols documentation><Psoriasis><Psoriasis Arthropathica><Psoriatic Arthritis><Quality Control><Recontacts><Registries><Research><Research Personnel><Research Resources><Researchers><Resources><Rheumatic Diseases><Rheumatism><Rheumatoid Arthritis><Rheumatologic Diseases><Rheumatologic Disorder><Rheumatology><SARS-CoV-2 infected patient><SARS-CoV-2 patient><SARS-CoV-2 positive patient><SLE><Sampling><Services><Site><Source><Specific qualifier value><Specified><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Stream><System><Systemic Lupus Erythematosus><Systemic Lupus Erythematous><Systemic Lupus Erythmatosus><Tissues><Translating><Translational Research><Translational Science><Woman><Work><adulthood><arthritic><arthritis registry><biobank><biological specimen archives><biomarker identification><biorepository><biosample archive><biospecimen archive><child patients><cohort><complex data><coronavirus disease 2019><coronavirus disease 2019 infected patient><coronavirus disease 2019 patient><coronavirus disease 2019 positive patient><coronavirus disease infected patient><coronavirus disease patient><coronavirus disease positive patient><coronavirus disease-19><coronavirus disease-19 patient><coronavirus infectious disease-19><coronavirus patient><data management><data sharing><developmental><disseminated lupus erythematosus><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><experience><flexibility><flexible><genomic data><genomic data-set><genomic dataset><genotyped patients><identification of biomarkers><identification of new biomarkers><immune check point inhibitor><immune-mediated adverse events><immune-related adverse effect><immune-related adverse events><immune-related adverse reaction><juvenile><juvenile human><kids><marker identification><meeting><meetings><member><online computer><participant recruitment><patient infected with COVID><patient infected with COVID-19><patient infected with SARS-CoV-2><patient infected with coronavirus disease><patient infected with coronavirus disease 2019><patient infected with severe acute respiratory syndrome coronavirus 2><patient with COVID><patient with COVID-19><patient with COVID19><patient with SARS-CoV-2><patient with coronavirus disease><patient with coronavirus disease 2019><patient with severe acute respiratory distress syndrome coronavirus 2><pediatric><pediatric patients><pediatric rheumatic diseases><personnel><prospective><psoriasiform><psoriatic><recruit><rheumatic arthritis><sample archive><severe acute respiratory syndrome coronavirus 2 infected patient><severe acute respiratory syndrome coronavirus 2 patient><severe acute respiratory syndrome coronavirus 2 positive patient><specimen archive><statistical analysis><systemic lupus erythematosis><tissue archive><translation research><translational investigation><web based><youngster>