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Principal Investigator: MELISSA LEWIS
Organization: UNIVERSITY OF MISSOURI-COLUMBIA
Fiscal Year: 2024
Award: $131,189
Funding agency: National Heart Lung and Blood Institute
ABSTRACT
American Indians (AI) have the largest prevalence of cardiovascular disease (CVD) in the nation with double the
prevalence compared to non-AIs. Programs developed and implemented in the general population to prevent
CVD may not be appropriate or effective for AI populations due to unique environmental barriers and cultural
differences. The PI, a member of the Cherokee nation, proposes a career development plan and research to
facilitate her development into a leader in interventions to prevent CVD and other negative health outcomes
among American Indians. The first specific aim is to adapt an existing Cherokee program to maximize reach to
more Cherokee Nation citizens and address primary prevention of CVD in Cherokee Nation (CN) adults. The
second aim is to conduct a pilot study to demonstrate acceptability and feasibility of the adapted intervention.
The third aim is to complete a rigorous career development plan including mentoring plans, training plans, and
pertinent coursework. The community-based participatory research project is centered in Tahlequah, Oklahoma
with the Cherokee Nation and built on a three-year research relationship between the tribe and the PI. Over this
time, the PI has worked with this community to evaluate a current Cherokee-created program, Remember the
Removal, that aims to improve the health and well-being of select young adult citizens through programs that
teach Cherokee culture, language and history along with improving diet and exercise. The new program, Journey
of Cherokees, to be developed with community participation, will build on the prior program’s foundation but
include expanded enrollment capacity, a larger age range, and flexible physical activity programs. The goal of
the proposed project is to advance the science of community-partnered generation of culturally specific health
interventions by promoting the power of cultural learning and cultural revitalization. The proposed research and
career development plan will position the PI to obtain R01 funding within the 5-year study period, and to become
a nationally recognized leader in innovative lifestyle interventions for preventing CVD and other negative health
outcomes among AIs.
Terms: <21+ years old><Abscission><Address><Adopted><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><Age><American Heart Association><American Indian><American Indian Population><American Indian group><American Indian individual><American Indian people><American Indians><BMI><BMI percentile><BMI z-score><Behavior><Blood Pressure><Body mass index><CVD prevention><Cardiovascular Diseases><Cause of Death><Cessation of life><Cherokee><Cherokee Indian><Cherokee Nation><Collaborations><Communities><Community Participation><Data Collection><Death><Development><Development Plans><Development and Research><Diet><Disparities><Disparity><Drugs><Education><Educational aspects><Educational process of instructing><Enrollment><Ensure><Evaluation Studies><Excision><Exercise><Exercise routine><Extirpation><Focus Groups><Foundations><Funding><Future><General Population><General Public><Generations><Goals><Health><History><Hypertension><Indigenous><Individuals from minority><Individuals of minority><Intervention><Intervention Strategies><Interview><Investigators><Ketosis-Resistant Diabetes Mellitus><Knowledge><Language><Learning><Life Style><Lifestyle><Maturity-Onset Diabetes Mellitus><Medication><Mental Depression><Mental Health><Mental Hygiene><Mentors><Methods><Minority Groups><Minority People><Minority Population><Minority individual><Morbidity><Morbidity - disease rate><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Obesity><Oklahoma><Outcome><Participant><Pathology><Personal Satisfaction><Persons><Pharmaceutical Preparations><Physical activity><Pilot Projects><Population><Position><Positioning Attribute><Prediabetes><Prediabetes syndrome><Prediabetic State><Prevalence><Prevention><Prevention program><Primary Prevention><Principal Investigator><Protocol><Protocols documentation><Psychological Health><Public Health><Quetelet index><R & D><R&D><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized, Controlled Trials><Recording of previous events><Removal><Reporting><Research><Research Activity><Research Grants><Research Methodology><Research Methods><Research Personnel><Research Project Grants><Research Projects><Researchers><Risk Factors><Science><Sedentary behavior><Sedentary life-style><Slow-Onset Diabetes Mellitus><Smoking><Social support><Stable Diabetes Mellitus><Stress><Surgical Removal><Survey Instrument><Surveys><T2 DM><T2D><T2DM><Teaching><Time><Training><Tribes><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Unhealthy Diet><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Work><Writing><acceptability and feasibility><adiposity><adult onset diabetes><adult youth><adulthood><aged><ages><cardiac disease prevention><cardiovascular disease prevention><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder prevention><cardiovascular disorder risk><cardiovascular health><career><career development><commune><community based design><community based participatory research><community based research><community led research><community participatory research><community partnered participatory research><community partners><community-based partners><corpulence><cultural values><depression><developmental><diet and exercise><diets><disease disparity><drug/agent><effectiveness trial><enroll><evidence base><exercise regimen><experience><federal policy><flexibility><flexible><health equity><healthy life-style><healthy lifestyle><high blood pressure><high risk group><high risk individual><high risk people><high risk population><histories><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><informant><innovate><innovation><innovative><interventional strategy><ketosis resistant diabetes><life style intervention><lifestyle intervention><maturity onset diabetes><member><mortality><new approaches><novel approaches><novel strategies><novel strategy><participatory action research><pilot study><pilot test><poor diet><pre-diabetes><pre-diabetic><prediabetic><premature><prematurity><prevent><preventing><programs><randomized control trial><research and development><research and methods><resection><sedentary lifestyle><skills><social><social culture><social support network><socio-cultural><sociocultural><success><successful intervention><trend><tribal Nation><tribal governance><tribal government><tribal self-governance><type 2 DM><type II DM><type two diabetes><well-being><wellbeing><young adult><young adulthood>