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Principal Investigator: SAMIA MORA
Organization: BRIGHAM AND WOMEN'S HOSPITAL
Fiscal Year: 2024
Award: $126,184
Funding agency: National Heart Lung and Blood Institute
Project Summary/Abstract Dr, Mora is a cardiologist cross-trained in epidemiology who has devoted her career to patient-oriented research (POR) in cardiovascular prevention, focusing on the discovery and translational applications of lipid biomarkers of cardiometabolic disease risk, and developing innovative approaches and therapies for preventing cardiometabolic disease. Her POR research has impacted national and international guidelines for clinical practice, In the first K24 cycle, she has mentored more than fifteen preand postdoctoral trainees in POR projects related to lipids, statins, and cardiovascular risk. This has been highlighted in recent years by the achievements of her mentees in presenting their work nationally and internationally, The K24 renewal award will allow her to extend her successful mentoring program. The overall goals of this K24 award are to 1) grow and expand her POR program by providing the next-generation of cardiovascular investigators with opportunities for precision POR in prevention by incorporating technologic advances in high-throughput metabolomics with clinical and health record data as a strategy to improve cardiovascular outcomes; and 2) strengthen and build upon her mentoring program in global cardiovascular health by expanding her POR program to examine cardiometabolic risk factors contributing to premature cardiovascular events. Cardiovascular disease remains the number one cause of death globally, and > 70% of cases can be attributed to cardiometabolic risk factors. Patients with uncontrolled cardiometabolic risk factors are at high risk of suffering from premature and recurrent cardiovascular events. The candidate's ongoing POR projects, exceptional institutional resources, and cost-effective local and international collaborations provide a nurturing environment for the training and career development of junior investigators in POR cardiovascular research. The new research aims proposed in this award will examine a panel of targeted metabolomics with risk of cardiovascular disease from diverse patient populations to better understand how cardiometabolic risk factors could be targeted for precision preventative diagnostic and therapeutic targets. This research program will provide excellent POR opportunities for junior investigators and trainees to be mentored across the full spectrum of clinical, epidemiological, and molecular studies. Results from this mentored POR program will guide future efforts directed at cardiovascular screening, risk stratification, and potentially more targeted precision medicine interventions to improve cardiovascular health. Towards that end, this K24 award will facilitate the progress of Dr, Mora's mentees into the next generation of patient-oriented independent cardiovascular researchers.
Terms: <21+ years old><Achievement><Achievement Attainment><Active Follow-up><Acute-Phase Proteins><Acute-Phase Reactants><Address><Adult><Adult Human><Age><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Award><BMI><BMI percentile><BMI z-score><Biological Markers><Blood Plasma><Body mass index><Boston><Branched-Chain Amino Acids><C-Peptide><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cause of Death><Cessation of life><Classification><Clinical><Collaborations><Coronary Disease><Coronary heart disease><Coupling><DEXA><DXA><Data><Death><Death Rate><Diabetes Mellitus><Diagnostic><Diet><Dual-Energy X-Ray Absorptiometry><Dual-Energy Xray Absorptiometry><Education><Educational aspects><Environment><Epidemiology><Ethnic Origin><Ethnicity><Event><Faculty><Future><Goals><Guidelines><Health><Healthcare><Heart Vascular><Hospitals><Humulin R><Impairment><Individual><Institution><Insulin><Insulin Resistance><Intermediary Metabolism><International><Intervention><Intervention Strategies><Investigation><Investigators><K24 Award><Life Style><Lifestyle><Lipids><Lipoprotein (a)><Lipoprotein Lp(a)><Long-Term Effects><Longterm Effects><Lp(a)><Measurement><Measures><Mentors><Metabolic Glycosylation><Metabolic Processes><Metabolic syndrome><Metabolism><Mid-Career Clinical Scientist Award (K24)><Modification><Molecular><Molecular Epidemiology><Novolin R><Nuclear Magnetic Resonance><Obesity><Omega-3 Fatty Acids><Omega-3 PUFA><Omega-3 Polyunsaturated Fatty Acid><Omega3><Onset of illness><Outcome><Over weight><Overweight><Patients><Physical activity><Plasma><Plasma Serum><Postdoc><Postdoctoral Fellow><Preventative measure><Preventative therapy><Prevention><Prevention Research><Preventive measure><Preventive therapy><Public Health><Public Health Schools><Quetelet index><R-Series Research Projects><R01 Mechanism><R01 Program><Random Allocation><Random Selection><Recommendation><Recurrence><Recurrent><Regular Insulin><Research><Research Associate><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Sampling><Smoking><South Asian><Systematics><Teaching Hospitals><Technology><Testing><Training><Trucial States><United Arab Emirates><VIT D><Vitamin D><Woman><Work><active followup><adiposity><adulthood><aged><ages><atheromatosis><atherosclerosis risk><atherosclerotic disease><atherosclerotic heart disease><atherosclerotic risk><atherosclerotic vascular disease><bio-markers><biologic marker><biomarker><branched amino acids><cardiometabolic><cardiometabolic risk><cardiometabolism><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular health><cardiovascular risk><cardiovascular risk factor><career><career development><case control><case-controlled><circulatory system><clinical practice><clinical risk><connecting peptide><coronary disorder><coronary event><corpulence><cost effective><diabetes><diets><disease onset><disease risk><disorder onset><disorder risk><epidemiologic><epidemiological><ethnic difference><ethnicity difference><experience><follow up><follow-up><followed up><followup><glycosylation><health care><health record><high risk><improved><inflammation marker><inflammatory marker><innovate><innovation><innovative><insulin resistant><insulin tolerance><interest><interventional strategy><medical college><medical schools><men><metabolism measurement><metabolomics><metabonomics><mortality><mortality rate><mortality ratio><multidisciplinary><n-3 Fatty Acids><new technology><next generation><novel><novel technologies><omega-3><patient centered><patient oriented><patient oriented research><patient oriented study><patient population><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><premature><prematurity><prevent><preventing><programs><recruit><research associates><research study><risk stratification><school of medicine><screening><screenings><sex><stratify risk><therapeutic target><translational applications><waist circumference><ω-3 fatty acids>