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Principal Investigator: MALLORY A PERRY-EADDY
Organization: UNIVERSITY OF CONNECTICUT STORRS
Fiscal Year: 2024
Award: $249,000
Funding agency: National Institute of General Medical Sciences
PROJECT SUMMARY/ABSTRACT
Sepsis in children is a leading cause of death and morbidity, yet little is known about its impact on physical
function after hospital discharge. Building upon the candidate’s prior biobehavioral research, this proposed
K99/R00 application will utilize symptom science approaches to explore the potential role of pro-inflammatory
mediators as they pertain to physical function in critically ill children who survive sepsis. This proposed
application aligns well with the mission of the National Institute for Nursing Research, “to promote and improve
the health and quality of life of individuals, families and communities.” The overall purpose of this K99/R00
application, Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC)
Postdoctoral Career Transition Award to Promote Diversity (PAR-19-343), is to prepare the candidate for an
independent career as a nurse scientist with a robust program of research in pediatric critical care and
symptom science. In the initial mentored phase (K99), the candidate will utilize existing data to (A1) develop
PEdiatric Recovery after sepSIS Treatment in the Pediatric Intensive Care Unit (PERSIST-PICU), a
multivariable model to identify risk physical dysfunction risk in critically ill children who survive sepsis. Sub aims
include (A1.1) associating the critically ill child’s course of illness with physical function after PICU discharge;
and (A1.2) associating the role of inflammation during critical illness on physical function after PICU discharge.
The candidate will develop a model through advanced statistical methods to identify children who are a-risk for
physical dysfunction after PICU discharge. In the independent phase (R00), the candidate will conduct a
prospective longitudinal cohort study to (A2) refine PERSIST-PICU model with new biological measures of
inflammation. Identification of critically ill children with sepsis who are at-risk for physical dysfunction after
discharge will provide an opportunity for early intervention to optimize their physical function after critical
illness. The mentored phase of this award (K99) will include training by a well-crafted, interprofessional team of
scientists who are experts in the proposed study design and advanced biostatistical modeling of inflammatory
biomarkers in pediatric critical care. In addition, the candidate has proposed an individualized training plan to
meet her unique training needs. The training plan includes attendance at the MOSAIC UE5 educational
conference, seminars, scientific meetings and targeted coursework. The candidate’s stellar mentorship team,
tailored research plan and findings within this K99/R00 application will prepare her well for transition to
independence as a nurse scientist in pediatric critical care and symptom science.
Terms: <0-11 years old><21+ years old><Active Follow-up><Acute Lung Injury><Acute Pulmonary Injury><Address><Adult><Adult Human><Age><Airway failure><Anionic Neutrophil-Activating Peptide><Award><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Biological><Biological Markers><Biometrics><Biometry><Biostatistics><C-reactive protein><Career Transition Award><Cause of Death><Chemotactic Factor, Neutrophil, Monocyte-Derived><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Communities><Complex><Critical Care><Critical Illness><Critically Ill><Critically ill children><Data><Data Set><Development><Dysfunction><Early Intervention><Early identification><Education><Educational aspects><Environment><Evaluation><Evolution><Family><Functional disorder><Future><GCP-IL-8><Genetic Diversity><Genetic Markers><Genetic Variation><Genotype><Granulocyte Chemotactic Peptide-Interleukin-8><Growth and Development><Growth and Development function><HPGF><Health><Hepatocyte-Stimulating Factor><Hospitals><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Iatrogenesis><Immersion><Individual><Infection><Inflammation><Inflammation Mediators><Inflammatory><Intensive Care><Interleukin-6><Interleukin-8><Intervention><Intervention Strategies><Investigators><Knowledge><Leukocyte Adhesion Inhibitor><Long-term cohort study><Longitudinal cohort study><Longterm cohort study><Lymphocyte-Derived Neutrophil-Activating Peptide><MGI-2><Macrophage-Derived Chemotactic Factor><Measures><Medical Rehabilitation><Mentors><Mentorship><Mission><Modeling><Monocyte-Derived Neutrophil-Activating Peptide><Morbidity><Morbidity - disease rate><Muscle Atrophy><Muscular Atrophy><Myeloid Differentiation-Inducing Protein><National Institute of Nursing Research><Nature><Neutrophil Activating Peptide><Neutrophil Activation Factor><Neutrophil Activation Peptide><Neutrophil Chemotactic Factor><Nurses><Pediatric Hospitals><Pediatric Intensive Care Units><Pediatrics><Pennsylvania><Performance><Phase><Phenotype><Philadelphia><Physical Function><Physiopathology><Plasmacytoma Growth Factor><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Predictive Analytics><Proteins, specific or class, C-reactive><QOL><Quality of life><Randomized><Recovery><Rehabilitation><Rehabilitation therapy><Reporting><Research><Research Associate><Research Design><Research Personnel><Researchers><Respiratory Failure><Risk><Role><Sampling><Scientist><Sedation procedure><Sepsis><Site><Statistical Methods><Study Type><Survivors><Syndrome><Techniques><Titrations><Training><Universities><Validation><Vulnerable Populations><Work><active followup><adulthood><ages><bio-markers><biobank><biobehavior><biobehavioral><biologic><biologic marker><biomarker><biorepository><blood infection><bloodstream infection><career><cohort><conference><convention><critically ill child><developmental><experience><follow up><follow-up><followed up><followup><gene biomarker><gene expression biomarker><gene marker><gene signature biomarker><genetic biomarker><iatrogenic><iatrogenically><iatrogenicity><improved><inflammatory mediator><interferon beta 2><interventional strategy><kids><meeting><meetings><model development><model developments><muscle breakdown><muscle degradation><muscle deterioration><muscle loss><muscle wasting><nurse><pathophysiology><pediatric><pediatric sepsis><pediatric septic><post-doc><post-doctoral><post-doctoral trainee><pre-doc><pre-doctoral><predoctoral><programs><prospective><randomisation><randomization><randomly assigned><rehab therapy><rehabilitative><rehabilitative therapy><research associates><sedation><sepsis in children><skills><social role><statistic methods><study design><summit><symposia><symposium><symptom science><validations><vulnerable group><vulnerable individual><vulnerable people><wasting><youngster>