Structural and functional characterization of phosphoglycosyl transferases from human pathogens

NIH Pandemic-Era Grants

Pandemic Era Grants

2021

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Principal Investigator: Gregory J Dodge
Organization: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Fiscal Year: 2021
Award: $34,281
Funding agency: National Institute of General Medical Sciences


Terms: <Active Sites><Address><Anabolism><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Assay><Bioassay><Biochemical><Biologic Assays><Biological><Biological Assay><Biological Function><Biological Process><C jejuni><C. jejuni><Campylobacter><Campylobacter jejuni><Choline Chloride Dihydrogen Phosphate><Choline Phosphate><Choline Phosphate Chloride><Crystallization><Deoxygalactose><Detergents><Development><Diffusion><Domestic Rabbit><E coli><E. coli><Environment><Enzyme Gene><Enzymes><Escherichia coli><Exhibits><Family member><Fucose><Glycans><Glycoconjugates><Glycoproteins><In Vitro><Integral Membrane Protein><Intrinsic Membrane Protein><Left><Libraries><Link><Lipid Bilayers><Lipids><Lipopolysaccharides><Membrane><Methods><Miscellaneous Antibiotic><Molecular><Nucleosides><Oryctolagus cuniculus><Phase><Phosphates><Phosphatides><Phosphocholine><Phospholipids><Phosphorylcholine><Phosphorylcholine Chloride><Play><Polymers><Polysaccharides><Proteins><Rabbits><Rabbits Mammals><Reporting><S aureus><S. aureus><Single Crystal Diffraction><Specificity><Staph aureus><Staphylococcus aureus><Structure><Styrenes><Substrate Interaction><Substrate Specificity><Techniques><Transferase><Transferase Gene><Transmembrane Protein><Transmembrane Protein Gene><UDP Sugars><Uridine Diphosphate Sugars><Virulence><X Ray Crystallographies><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray/Neutron Crystallography><Xray Crystallography><alpha-Fucose><bacteria pathogen><bacterial pathogen><base><biosynthesis><colanic acid><copolymer><design><designing><developmental><enzyme substrate complex><experiment><experimental research><experimental study><extracellular><human pathogen><immunogenicity><in vivo><inhibitor><inhibitor/antagonist><inorganic phosphate><insight><lipid bilayer membrane><lipid-linked oligosaccharides><lipooligosaccharide><luminescence><macromolecule><maleic acid><membrane structure><nano particle><nano-sized particle><nanoparticle><nanosized particle><pathogen><pathogenic bacteria><prevent><preventing><protein data bank><protein databank><screening><sugar><vapor><vector>