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Principal Investigator: Philipp Gutruf
Organization: UNIVERSITY OF ARIZONA
Fiscal Year: 2024
Award: $428,357
Funding agency: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Project Summary
Osteopenic fragility fractures are a devastating result of poor bone quality secondary to high mortality and long-
term patient disability. Currently there is limited understanding on the mechanistic level reflected in the relatively
few available treatment and diagnostic options. Dual-energy x-ray absorptiometry (DEXA) is utilized in
combination with established patient standards for diagnosis and management of osteoporosis, however its use
is limited in patients. There is a clear need to improve technologies that enable bone quality measurements,
especially to avoid refracture.
In the proposed work we will develop technology that enables chronic insight into bone health for rodent animal
models to enable real-time high-fidelity readout enabling advanced insight for the study of mechanisms and to
evaluate the efficacy of new treatments. Specifically, we will build on our recently introduced device class,
osseosurface electronics, which are battery free and fully implantable bone strain monitors.
In aim 1 we will evaluate permanent interfacing and sensing capabilities of the platform that is grown to the bone
via calcium phosphate ceramic particles on month long timescales. Data captured from daily exercise on a
treadmill will enable insight in sensing fidelity and will be compared against gait parameters automatically
captured by deep neural net image analysis. In aim 2 we will develop a new sensing modality, thermal
conductivity measurements, that will be validated by the attachment of the biointerface to the bone, a mechanism
we already characterized with strain sensors. This platform will then be used to compare the sensitivity of serial
DEXA, µCT, in vivo strain and thermal conductivity measurement in detecting bone changes following
administration of an anabolic medication used to treat osteoporosis in aim 3. Ovariectomy animal models with
and without treatment will be evaluated by osseosurface electronics against DEXA and µCT.
Successful expansion of our osseosurface electronic platform will enable new real time and high-fidelity
measurement of bone health in freely moving small animal models. This capability is instrumental to explore
mechanisms of chronic and acute changes attributed to fracture or disease in models that have the full genetic
toolset and enable rapid test of hypothesis with little cost. The experiments will also inform the utility of the
devices towards the use in patients for chronic treatment of osteoporosis.
Terms: <2 year old><2 years of age><Acute><Age><Age Years><Animal Model><Animal Models and Related Studies><Bed Occupancy><Bone Density><Bone Mineral Density><Breast Cancer><Budgets><Cardiac infarction><Caring><Ceramics><Chronic><Clinical><Cost Savings><DALY><DEXA><DXA><Data><Development><Devices><Diagnosis><Diagnostic><Disease><Disorder><Drugs><Dual-Energy X-Ray Absorptiometry><Dual-Energy Xray Absorptiometry><Effectiveness><Electrical Impedance><Electronics><Engineering><Exercise><Forteo><Fracture><Fracture due to osteoporosis><Free Will><Future><Gait><Generalized Growth><Genetic><Growth><Healthcare><Hip Fractures><Image Analyses><Image Analysis><Impedance><Implant><Incidence><Investigation><Malignant Breast Neoplasm><Malignant Tumor of the Prostate><Malignant neoplasm of prostate><Malignant prostatic tumor><Measurement><Measures><Medication><Methods><Modality><Modeling><Monitor><Myocardial Infarct><Myocardial Infarction><Oophorectomy><Osteopenia><Osteopenias><Osteoporosis><Osteoporosis with fracture><Osteoporotic fracture><Ovariectomy><PTH gene><PTH(1-34)><Parathyrin><Parathyroid Hormone><Patients><Performance><Persons><Pharmaceutical Preparations><Population><Prevalence><Prostate CA><Prostate Cancer><Prostate malignancy><Prostatic Cancer><QOL><Quality of life><Resolution><Risk><Risk Factors><Rodent><Rodent Model><Rodentia><Rodents Mammals><Savings><Secondary to><Skin><Surface><Technology><Temperature Sense><Teriparatide><Testing><Therapeutic><Thermal Conductivity><Time><Tissue Growth><Work><age 2 years><aged 2 years><aged two years><ages><bed days><bone><bone fracture><bone health><bone quality><calcium phosphate><calcium phosphate coating><cardiac infarct><compact bone><coronary attack><coronary infarct><coronary infarction><cortical bone><cost><cost estimate><cost estimation><deep learning based neural network><deep learning neural network><deep neural net><deep neural network><determine efficacy><developmental><diagnosis standard><disability><disability-adjusted life years><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electric impedance><electronic><electronic device><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><female gonadectomy><fracture risk><fragility fracture><hPTH (1-34)><health care><heart attack><heart infarct><heart infarction><hospital bed><image evaluation><image interpretation><improved><in vivo><innovate><innovation><innovative><insight><malignant breast tumor><model of animal><mortality><multi-modality><multimodality><ontogeny><operation><operations><osteoporosis associated fracture><osteoporosis related fracture><osteoporosis with pathological fracture><parathormone><parathyroid hormone (1-34)><particle><rapid assay><rapid test><rapid tests><resolutions><response to therapy><response to treatment><sensor><temperature sensation><temporal measurement><temporal resolution><therapeutic response><therapy response><thermoreception><time measurement><tool><translational study><treadmill><treatment response><treatment responsiveness><two year old><two years of age><wireless><wireless device><wireless electronic>