A Nanovaccine for Eliciting Broadly Neutralizing Antibodies Against HIV-1

NIH Pandemic-Era Grants

Pandemic Era Grants

2020

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Principal Investigator: CHOWDA  VENKATARAVAPPA
Organization: NEOVAXSYN, INC.
Fiscal Year: 2020
Award: $299,999
Funding agency: National Institute of Allergy and Infectious Diseases

Particle-Based Co-Delivery of HIV Immunogens as Next-Generation HIV Vaccines: A major focus of HIV vaccine research has been the development of immunogens that elicit broadly neutralizing antibody responses targeting the envelope protein (Env). While the field has predominantly focused on immunogen design and soluble antigens, the targeted and controlled delivery of antigens has not received much attention and is a gap in the HIV field that needs to be addressed. Tailored immunogens (such as Envs, monomers, native and/or native-like trimers, nucleic acids/RNA such as mRNAs, selfamplifying RNAs) combined with an effective multivalent antigenic display on nanoparticles for delivery may provide a strategy to promote strong and long-lived neutralizing antibody responses against HIV and direct affinity maturation toward HIV neutralizing antibodies.

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