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Principal Investigator: Jody M. Ganiban
Organization: UNIVERSITY OF OREGON
Fiscal Year: 2024
Award: $1,748,806
Funding agency: NIH Office of the Director
Project Summary
The combined economic and personal effects of children’s neurodevelopmental problems, such as conduct
disorder, ADHD, and depression and anxiety symptoms are substantial. At the same time, there is growing
evidence that dimensions of positive health can support children in leading meaningful, productive lives. In the
current proposal we address knowledge gaps related to the timing of psychosocial environmental exposures
and when their effects on child neurodevelopment and positive health emerge, and at what ages children’s risk
factors and assets are most potent in affecting developmental trajectories. We also propose to examine the
transition to adolescence. Adolescence can be a turning point in child development given rapid changes in the
brain, emotional, and social system, yet longitudinal studies from infancy to adolescence with large cohorts of
children from diverse backgrounds are sorely lacking. Last, children’s neurodevelopment and positive health
are rarely examined in concert, leading to incomplete assessments of children’s mental health at all phases of
development. This application seeks to fill some of these knowledge gaps through participation in the
Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites for Pediatric Follow Up
Program. In this application, we propose to follow an existing sample of 1,000 children from the Early Growth
and Development Study (EGDS) cohort who are enrolled as Level 2 participants in the ECHO Program and
have ECHO Cohort Protocol data elements beginning in the prenatal period. EGDS is a nationwide sample of
children living with either their adoptive or biological parent(s). Children will be age 7 – 20 years old and
assessed annually using the ECHO Cohort Protocol in the proposed study. We have been highly successful in
achieving our planned recruitment and enrollment rates, collecting and sharing data with the ECHO Program,
and contributing to ECHO-wide science and manuscripts in the current ECHO funding cycle. We will build on
our successes and infrastructure to contribute to ECHO’s goals through leading collaborative ECHO Cohort
science, with a dual focus on ECHO Cohort Protocol core data elements and on two specialized child outcome
areas: Neurodevelopment and Child Positive Health. Through three specific aims, we will: (1) leverage ECHO
Cohort Protocol core data elements to examine the immediate and latent impact of early exposures on child
health outcomes across different developmental periods in diverse contexts; (2) leverage data from specialized
outcomes to test predictors of change in neurodevelopment and positive health in adolescence; and, (3)
implement data-driven check points every quarter to assess our retention of existing cohort participants, with
an emphasis on diversity and implementation of the protocol with high fidelity. Our overall goal is to work
collaboratively with the ECHO Program to advance the understanding of predictors and outcomes of child
health in order to inform programs, practices, and policies that will improve the health of children for
generations to come.
Terms: <0-11 years old><12-20 years old><20 year old><20 years of age><6-11 years old><AD/HD><ADHD><Active Follow-up><Address><Adherence><Adolescence><Adolescent><Adolescent Youth><Affect><Age><Area><Attention deficit hyperactivity disorder><Award><Biological><Biology><Birth><Brain><Brain Nervous System><Calibration><Characteristics><Child><Child Development><Child Health><Child Mental Health><Child Rearing><Child Support><Child Youth><Childbirth><Childhood><Children (0-21)><Classification><Cognitive Discrimination><Cohort Studies><Conceptions><Concurrent Studies><Conduct Disorder><Data><Data Element><Development><Dimensions><Discrimination><Economics><Emotional><Emotional Depression><Encephalon><Enrollment><Ensure><Environment><Environmental Exposure><Esthesia><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Family><Follow-Up Studies><Followup Studies><Funding><Generalized Growth><Generations><Geography><Gestation><Goals><Growth><Growth and Development><Growth and Development function><Health><Individual><Individual Differences><Infant and Child Development><Infrastructure><Intervention><Intervention Strategies><Interviewer><Investigation><Investigators><Knowledge><Lead><Link><Longitudinal Studies><Low income><Manuscripts><Mental Health><Mental Hygiene><Methods><Minority><Modeling><Neighborhoods><Neural Development><Neurodevelopmental Problem><Outcome><Outcome Measure><Parenting><Parenting behavior><Parents><Participant><Parturition><Pb element><Pediatric cohort><Phase><Policies><Population Heterogeneity><Predisposition><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Pregnancy><Process><Productivity><Protocol><Protocols documentation><Psychological Health><Psychologist><Puberty><Racial Group><Research Design><Research Infrastructure><Research Personnel><Researchers><Risk><Risk Factors><Role><Sampling><Science><Sensation><Shapes><Siblings><Site><Societies><Standardization><Study Type><Susceptibility><System><Systematics><Temperament><Testing><Time><Tissue Growth><Training><Work><active followup><adolescence (12-20)><age 20 years><aged><ages><anxiety symptoms><anxious symptom><biologic><child birth><childrearing><cohort><data sharing><depression symptom><depressive><depressive symptoms><design><designing><developmental><disorder of conduct><disorders of conduct><diverse populations><economic><enroll><ethnic subgroup><ethnicity group><follow up><follow-up><followed up><followup><heavy metal Pb><heavy metal lead><heterogeneous population><improved><infancy><infantile><insight><interventional strategy><juvenile><juvenile human><kids><life span><lifespan><long-term study><longitudinal outcome studies><longterm study><measurable outcome><middle childhood><neurodevelopment><novel><ontogeny><outcome measurement><parent><pediatric><peer><phase 2 study><phase II study><population diversity><prenatal><programs><protective factors><psychosocial><racial identity><racial population><racial subgroup><recruit><resilience><resilient><retention rate><retention strategy><rural area><rural location><rural region><social><social role><study design><success><twenty year old><twenty years of age><unborn><urban area><urban location><urban region><youngster>