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Principal Investigator: Rami Kantor
Organization: MIRIAM HOSPITAL
Fiscal Year: 2024
Award: $196,366
Funding agency: National Institute of Allergy and Infectious Diseases
HIV Drug Resistance, Monitoring and Transmission Rami Kantor, MD
SUMMARY
My career passions have always been mentoring in and conducting HIV-related patient-oriented research. I’ve
developed a multidisciplinary research portfolio, combining patient care with clinical, laboratory and
bioinformatics translational research, in national and international settings. This diverse range provided the basis
for this Mid-Career Investigator award, which offered plenty of opportunities for mentoring and research. Prior to
and during this past cycle I have mentored numerous trainees at various stages and settings, including post-
doctoral fellows and junior faculty, which resulted in presentations, publications, grant productivity and career
developments. My research focus has always been HIV in adults and children, specifically focused on drug
resistance, treatment monitoring and transmission. My three current R01s and additional grants, my laboratory,
the Providence-Boston Center for AIDS Research, the very strong institutional commitment, and the outstanding
infrastructures at Brown University and its affiliated hospitals, including federally funded training Programs and
Centers, will all continue to serve as strong sources, resources and foundation for this K24 Renewal, and will
provide exceptional capacity and a multidisciplinary platform for mentees. Building on my research expertise,
current R01 funding, and the last K24 cycle, the Research Specific Aims of this K24 are to (1) Investigate HIV
drug resistance gaps and their impact in diverse settings and populations (supported by R01AI147333);
(2) Disrupt HIV transmission by integrating molecular epidemiology into public health (supported by
R01AI136058); and (3) Examine drug resistance upon incorporation of high-drug-resistance barrier drugs
and regimens into all antiretroviral therapy lines (supported by this K24 and my institutional funds). The
Mentoring Specific Aim of this K24, that will accompany all research Aims, is to mentor new investigators in
multidisciplinary patient-oriented research. I will accomplish these Aims by continuing to recruit passionate,
committed, and potent individuals from the rich local infrastructure, and using my diverse research portfolio to
develop specific and individual mentoring plans for them to match their short and long-term goals. Based on
specific projects on HIV drug resistance, monitoring and transmission, mentees will receive training on topics
such as generation of research ideas, obtaining funding and human subjects approvals, study and protocol
design, staff recruitment and training, patient enrollment, sample collection, laboratory assays and experiments,
and data analysis, presentation, and dissemination. This K24 will continue to provide 50% of my salary and
additional funds to support mentees’ research, as well as protected time for my own development towards
becoming a better researcher and mentor. Augmented by my own, continuous, immediately available NIH-
funded research support and institutional funds, this K24 will support me to increase the pool of well-trained
clinical researchers of the future and to mentor a new generation of junior investigators in HIV related patient-
oriented research towards their independence.
Terms: <0-11 years old><21+ years old><AIDS><AIDS Virus><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Address><Adult><Adult Human><Ambulatory Care><Anti-HIV resistance><Anti-HIV resistant><Anti-Retroviral Agents><Assay><Award><Basic Research><Basic Science><Bio-Informatics><Bioassay><Bioinformatics><Biological Assay><Boston><COVID-19><CV-19><Child><Child Youth><Children (0-21)><Clinical><Communicable Disease Contact Tracing><Contact Tracing><Coronavirus Infectious Disease 2019><Data Analyses><Data Analysis><Dedications><Development><Doctor of Philosophy><Drug resistance><Drug resistance in HIV><Drugs><Ensure><Epidemic><Faculty><Foundations><Funding><Future><Generations><Genetic><Goals><Grant><Growth and Development><Growth and Development function><HIV><HIV drug resistance><HIV drug resistant><Hospitals><Human Immunodeficiency Viruses><India><Individual><Infectious Disease Contact Tracing><Infrastructure><Institution><Interdisciplinary Research><Interdisciplinary Study><International><Investigators><Kenya><LAV-HTLV-III><Laboratories><Lymphadenopathy-Associated Virus><Medication><Mentors><Mentorship><Molecular Epidemiology><Monitor><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Outpatient Care><Patient Care><Patient Care Delivery><Persons><Ph.D.><PhD><Pharmaceutical Preparations><Philosophy><Phylogeny><Population><Postdoc><Postdoctoral Fellow><Prevention><Productivity><Protocol><Protocols documentation><Public Health><Publications><Regimen><Research><Research Associate><Research Personnel><Research Resources><Research Support><Researchers><Resistance><Resources><Salaries><Scientific Publication><Source><Time><Training><Training Programs><Translational Research><Translational Science><Transmission><Travel><Treatment Failure><Underrepresented Ethnic Minority><Underrepresented Minority><United States National Institutes of Health><Universities><Virus-HIV><Wages><absorption><adulthood><anti-retroviral><antiretroviral therapy><antiretroviral treatment><care for patients><care of patients><career><career development><caring for patients><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><data interpretation><design><designing><developmental><drug resistant><drug resistant HIV><drug/agent><experience><experimental analysis><human subject><improved><innovate><innovation><innovative><inpatient care><inpatient service><kids><multidisciplinary><outpatient treatment><participant enrollment><patient enrollment><patient oriented research><patient oriented study><post-doc><post-doctoral><post-doctoral trainee><recruit><research associates><resistance to Drug><resistance to HIV drug><resistance to anti-HIV><resistant><resistant to Drug><resistant to HIV drug><sample collection><specimen collection><therapy failure><translation research><translational investigation><transmission process><under-representation of minorities><under-represented minority><underrepresentation of minorities><youngster>