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Principal Investigator: Valerie Chock
Organization: STANFORD UNIVERSITY
Fiscal Year: 2024
Award: $331,108
Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development
PROJECT SUMMARY
The Division of Neonatal and Developmental Medicine at Stanford University submits a competing renewal
application to participate in the NICHD Neonatal Research Network (NRN). The Division and its faculty
members have a long history of innovative research accomplishments in neonatal medicine. This expertise
dovetails with the NRN goal of conducting definitive and rigorous multicenter trials and observational studies in
newborns to improve survival without neurodevelopmental impairment. As a participant in the NRN since 1991,
this center has proven to be highly productive, contributing to leadership, study design, protocol development,
execution, analysis, and results dissemination. Led by PI, Krisa Van Meurs, Alternate PI, Valerie Chock, and
Follow-up PI, Susan Hintz, the site neonatologists and subspecialty collaborators have wide-ranging expertise
and significant clinical research experience with 613 manuscripts published in neonates since 2016. Within the
NRN, Stanford investigators have 55 subcommittee assignments and appear as co-authors 117 times on NRN
manuscripts. Dr. Van Meurs is Chair of the Publications Committee and coordinated 131 manuscript reviews,
spearheaded a review of NRN policies leading to a reduction in time to publication, and was Editor for the
Seminars in Perinatology volume describing NRN contributions over the last grant cycle. As Lead Follow-up PI
and Chair of Follow-up Protocol Development, Dr. Hintz has been responsible for advancing protocols and
proposals, and assuring the quality of NRN follow up visits, and enhancing rigor of training and certification
procedures. During the COVID pandemic she led re-envisioning of certification processes, launched new tools,
and developed individualized improvement plans for challenged sites. Cody Arnold is Co-PI for the ongoing
Cycled Phototherapy trial. Valerie Chock led a NHLBI-funded secondary to the Transfusion in Prematures trial
on near-infrared spectroscopy (NIRS), Dr. Van Meurs led a secondary to the Optimizing Cooling trial on
amplitude-integrated EEG, and Courtney Wusthoff led a secondary study to the Preemie Hypothermia trial on
EEG. Stanford neuroradiologists have been MRI central readers for all the NRN cooling trials. The Stanford
site with its 2 satellite sites, El Camino Hospital and Santa Clara Valley Medical Center, provide an annual
delivery base of >12,000 births with 59% born to high risk mothers, 140 NICU beds, and >1900 NICU
admissions with 83% inborn. Two sites anticipate growth in deliveries over the next 3 years. Our aggregate
population is diverse in comparison to the rest of the US with 25% Asian and 52% Hispanic. Over the last 6
grant cycles Stanford has demonstrated wide-ranging expertise, exceptional leadership, and strong
collaborative abilities that have served the NRN well. One of the greatest strengths Stanford has to offer is our
extensive and talented pool of young clinical investigators that will become the clinical research leaders of the
future. In summary, the Stanford site has the neonatal and subspecialty faculty, physical space, research
resources, professional staff, institutional support, and patient population necessary to continue as one of the
finest centers participating in the NRN.
Terms: <0-4 weeks old><Academic Medical Centers><Actinotherapy><Active Follow-up><Address><Admission><Admission activity><Adoption><Advisory Committees><Area><Asian><Asian group><Asian individual><Asian people><Asian population><Asians><Beds><Birth><Blood Transfusion><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Caring><Cerebrum><Certification><Clinical Investigator><Clinical Research><Clinical Study><Collaborations><Communities><Congresses><Data Coordinating Center><Data Coordination Center><Development><Disparities><Disparity><EEG><Education><Educational aspects><Electroencephalogram><Electroencephalography><Ensure><Faculty><Family><Funding><Future><Generalized Growth><Goals><Grant><Growth><HEAL Initiative><Healthcare><Helping End Addiction Long-term><Helping End Addiction Longterm><Helping to End Addiction Long-term><Helping to End Addiction Longterm><Hispanic><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><History><Hospitals><Hypothermia><Industry><Infant><Infant Care><Information Dissemination><Institution><Intervention Trial><Interventional trial><Investigation><Investigators><Journals><Lactation><Lead><Leadership><Light Therapy><Low Birth Weight Infant><MR Imaging><MR Tomography><MRI><MRIs><Magazine><Magnetic Resonance Imaging><Manuscripts><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical center><Medicine><Mission><Morbidity><Morbidity - disease rate><Mothers><Multi-Institutional Clinical Trial><Multi-center Neonatal Research Network><Multi-center clinical trial><Multi-center trial><Multi-site clinical trial><Multicenter Neonatal Research Network><Multicenter Trials><Multicenter clinical trial><Multisite clinical trial><NHLBI><NICHD><NIH><NIR Spectroscopy><NMR Imaging><NMR Tomography><National Heart, Lung, and Blood Institute><National Institute of Child Health and Human Development><National Institute of Children's Health and Human Development><National Institutes of Health><Near-Infrared Spectrometry><Near-Infrared Spectroscopy><Neonatal><Neonatal Research Network><Neonatology><Neurodevelopmental Impairment><Newborn Infant><Newborns><Nuclear Magnetic Resonance Imaging><Observation research><Observation study><Observational Study><Observational research><Outcome><Oximetry><Oxygen saturation measurement><Participant><Parturition><Patient Care><Patient Care Delivery><Patients><Pb element><Peer Review><Perinatology><Photoradiation Therapy><Phototherapy><Policies><Population><Population Heterogeneity><Position><Positioning Attribute><Pregnant Women><Premature Infant><Procedures><Process><Productivity><Protocol><Protocols documentation><Public Health><Publications><Publishing><QOC><Quality of Care><Randomization trial><Reader><Recording of previous events><Reproducibility><Research><Research Design><Research Personnel><Research Resources><Researchers><Resources><Rest><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Scientific Publication><Secondary to><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Site><Study Type><Talents><Task Forces><Time><Tissue Growth><Training><Transfusion><Underserved Population><United States National Institutes of Health><Universities><University Medical Centers><Visit><Woman><Zeugmatography><active followup><advisory team><baby care><base><bases><care for patients><care of patients><caring for patients><cerebral><clinical center><clinical research site><clinical site><community engagement><conference><convention><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><data management and coordinating center><data management center><demographics><developmental><dissemination of results><diverse populations><engagement with communities><expectant mother><expecting mother><experience><follow up><follow-up><followed up><followup><health care><health goals><heavy metal Pb><heavy metal lead><heterogeneous population><high risk><histories><improved><infant health care><infant healthcare><infants born premature><infants born prematurely><innovate><innovation><innovative><lactating><lactational><light intervention><light treatment><low birth weight><low birthweight><member><natural hypothermia><neonatal care><neonatal encephalopathy><neonate><new approaches><new technology><newborn care><newborn child><newborn children><novel approaches><novel strategies><novel strategy><novel technologies><ontogeny><opiate exposure><opioid exposure><outcome prediction><pandemic><pandemic disease><patient population><perinatal medicine><population diversity><pregnant mothers><premature><premature baby><premature infant human><prematurity><preterm baby><preterm infant><preterm infant human><protocol development><randomized trial><safety net><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><study design><summit><symposia><symposium><tool><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people>