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Principal Investigator: Viren Andrew D'Sa
Organization: RHODE ISLAND HOSPITAL
Fiscal Year: 2024
Award: $1,995,044
Funding agency: NIH Office of the Director
PROJECT SUMMARY / DESCRIPTION
How does a healthy child grow? Asked by every parent, the simplicity of this question masks the complex nature
of child development and makes light of the diverse environmental factors and variables that shape a child’s
emerging physical health and neurodevelopment. Beginning at conception and accelerating throughout
childhood and adolescence, our unique environmental exposures and social experiences shape our behaviors,
impact our health, and influence our developing cognitive skills and abilities. Far from being distinct entities,
aspects of physical health and neurodevelopment evolve dynamically together in a bi-directional feedback cycle
that promotes healthy or rapidly worsening outcomes. At every stage of this cycle, factors that affect the child
(e.g., sleep, chemical exposures, discrimination), their family (e.g., family sociodemographic characteristics),
and their neighborhood (e.g., neighborhood safety, school quality) can improve health or accelerate decline.
Over the past two years, the COVID-19 pandemic has ushered in widespread disruptions to almost every
aspect of a child and family’s life, with disproportionate impacts on lower-income, and racial and ethnic minority
families. Differences in public health responses across the ECHO Cohort offer an important opportunity to
understand how these multi-level factors, including social determinants of health (SDoH), have moderated child
physical health and neurodevelopment. Leveraging the ECHO Cohort and taking a team science approach, this
proposal aims to understand the dynamic relationships that link child neurodevelopment and two pressing public
health challenges: pediatric asthma and obesity; and the influence of specific multi-level moderators (chemical
exposures, child sleep, physical activity, and key SDoH factors). We will examine: 1. How child
neurodevelopment and physical health outcomes, specifically asthma, and obesity are shaped by chemical,
biological, and social environmental exposures; 2. How physical health and neurodevelopment co-develop and
reinforce each other throughout childhood; 3. How lived experiences across the child, family, and neighborhood
contexts, including SDoH, moderate neurodevelopmental outcomes; and 4. How these relationships have been
changed by the COVID-19 pandemic and varied across racial, ethnic, and socioeconomic dimensions. Through
a comprehensive Plan for Enhancing Diverse Perspectives (PEDP), we take an intentional approach to include
the social, psychosocial, and economic inequalities, constraints, and behavioral norms that underlie disparities
in neurodevelopment and child physical health outcomes. With core tenets of access and inclusion, we will re-
enroll our Cohort Study Site (RESONANCE) comprising >1650 well-characterized family-child dyads from
diverse sociodemographic backgrounds across Rhode Island. Using novel remote data collection and mobile
labs, we will address traditional barriers to research participation and access while ensuring adherence and high
data quality across all core elements and biospecimens. Outcomes from our solutions-oriented research will
have a direct and meaningful impact on health interventions and public policy guidance.
Terms: <0-11 years old><12-20 years old><Acceleration><Accounting><Address><Adherence><Adolescence><Affect><Anthropometry><Area><Asthma><Asthma in Children><Behavior><Behavioral><Biological><Birth><Bronchial Asthma><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Characteristics><Chemical Exposure><Chemicals><Child><Child Development><Child Health><Child Youth><Childhood><Childhood Asthma><Children (0-21)><Cognitive><Cognitive Discrimination><Cohort Analyses><Cohort Analysis><Cohort Studies><Collaborations><Collection><Communities><Complex><Conceptions><Concurrent Studies><Data><Data Collection><Diet><Dimensions><Disadvantaged><Discrimination><Disparities><Disparity><Disparity population><Economically Deprived><Economics><Education><Educational aspects><Elements><Enrollment><Ensure><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Ethnic Origin><Ethnicity><Evidence based intervention><Face><Family><Feedback><Genetic><Genetic Risk><Guidelines><Health><Home><Individual><Inequality><Inequity><Infant and Child Development><Intervention><Intervention Strategies><Investigators><Knowledge><Life><Light><Link><Lived experience><Lived experiences><Low income><Masks><Maternal Health><Measures><Minority><Nature><Neighborhoods><Neural Development><Obesity><Outcome><Parents><Participant><Parturition><Pathway interactions><Pediatric asthma><Photoradiation><Physical activity><Policies><Probabilistic Models><Probability Models><Process><Public Health><Public Policy><Race><Races><Recovery><Research><Research Personnel><Researchers><Rhode Island><Risk><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sample Size><Schools><Science><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Site><Sleep><Spanish/English><Spirometry><Statistical Models><Talents><Testing><Time><Visit><Weight><adiposity><adolescence (12-20)><biologic><child adiposity><child obesity><childhood adiposity><childhood obesity><cognitive ability><cognitive assessment><cognitive development><cognitive function><cognitive skill><cognitive testing><cohort><community safety><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><corpulence><data quality><diets><disadvantaged group><disadvantaged individual><disadvantaged people><disadvantaged population><disadvantaged subgroup><disparities across groups><disparity across subgroups><disparity among groups><disparity among subgroups><disparity between groups><disparity between subgroups><disparity in health><early life exposure><economic><economic disparity><economically disadvantaged><educationally disadvantaged><enroll><environmental risk><ethnic minority><executive control><executive function><experience><exposed in utero><faces><facial><fetal exposure><group disparity><group inequality><group inequity><health disparity><homes><improved><in utero exposure><inequalities among populations><inequalities between populations><inequalities in populations><inequality across populations><inequality among groups><inequality between groups><inequality in groups><inequities among populations><inequities between populations><inequities in populations><inequity across groups><inequity across populations><inequity between groups><inequity in groups><innovate><innovation><innovative><interventional strategy><intra-uterine environmental exposure><intrauterine environmental exposure><kids><mindfulness><neighborhood safety><neurodevelopment><novel><obese children><obesity during childhood><obesity in children><pandemic><pandemic disease><parent><pathway><pediatric><pediatric obesity><physical conditioning><physical health><pollutant><population inequality><population inequity><postnatal><prenatal><prenatal exposure><prenatally exposed><psychosocial><public health research><racial><racial background><racial minority><racial origin><residential segregation><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social><social disadvantage><social disparities><social health determinants><social inequality><socio-demographics><socio-economic><socio-economically><sociodemographics><socioeconomically><socioeconomics><statistical linear mixed models><statistical linear models><subgroup disparity><unborn><unequal group><unequal population><weights><youngster>