Document text
Principal Investigator: Shannon Jones McCall
Organization: DUKE UNIVERSITY
Fiscal Year: 2024
Award: $719,670
Funding agency: National Cancer Institute
PROJECT ABSTRACT
High-quality biospecimens are critical to cancer research. The CHTN Southern Division leverages the CAP-
accredited biorepository broad-consent framework and faculty/staff expertise of the Duke BioRepository &
Precision Pathology Center (BRPC) to provide high-quality biospecimens to investigators through the National
Cancer Institute’s Cooperative Human Tissue Network (CHTN). Distribution of high quality biospecimens and
data and the additional CHTN missions of biobanking best practice dissemination and community education
are addressed through the following four specific aims. Aim 1: Efficiently provide high-quality tissue, blood
and fluid biospecimens to CHTN investigators for basic and early translational research. Specimen collection
is facilitated at Duke University Hospital and Duke networked hospitals Duke Regional Hospital and Duke
Health Raleigh Hospital, as well as the CHTN Southern Division subsite at Atlantic Health System in
Morristown, New Jersey. The latest technologies in sample processing including viable specimen preservation,
tumor enrichment, nucleic acid extraction, genotyping, biomarker phenotyping, whole slide imaging, tissue
microarray, immunohistochemistry, digital image analysis and digital spatial profiling are also available. Aim
2: Provide consultation. Duke pathologists and biorepository staff provide expert consultation to CHTN
investigators on use of human biospecimens, assay selection and sample processing with an eye toward fit-
for-purpose pre-analytics. Aim 3: Develop and disseminate knowledge on high-quality practices for
biorepositories. This CHTN Southern Division team will take on new projects and disseminate results through
publication and presentation at national and international meetings. The Southern Division PI will continue to
serve in national and international leadership roles within the biorepository community. Aim 4: Educate the
local, regional and national community on the importance of biospecimens in biomedical research. Locally, the
CHTN Southern Division at Duke University will continue to engage the Durham, NC community through the
Duke Cancer Institute’s Community Outreach & Engagement Core, participating in two-way dialogue through
events such as Community-Scientist Roundtables and Biobank tours, seeking specifically increasing the
number of samples available for research from underrepresented populations. The Southern Division will
continue to leverage opportunities to educate the public and the scientific community about the importance of
having sufficient, high-quality, annotated biospecimens available for research. Examples include podcasts,
meeting presentations geared toward general scientific research audiences, newsletters, and social media
postings.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Accreditation><Addendum><Address><American><Assay><Assessment instrument><Assessment tool><Audience Research><Autopsy><BFR-1><Bioassay><Biologic Preservation><Biological><Biological Assay><Biological Preservation><Biomedical Research><Biopsy><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Body Tissues><Bone Metastasis><Bone cancer metastatic><Bony metastasis><Breast><CHTN><COVID-19 virus><COVID19 virus><Calcified><Cancer Model><CancerModel><Cancers><Caring><Clinical Data><CoV-2><CoV2><Collection><Colon Cancer><Colon Carcinoma><Communication><Communities><Community Education><Community Health Education><Community Outreach><Consent><Consultations><Continuance of education><Continuing Education><Cooperative Human Tissue Network><Data><Dedications><Dermatopathology><Diagnosis><Disease><Disorder><E-learning><Ensure><Event><FGFR2><FGFR2 gene><Faculty><Feedback><Fibroblast Growth Factor Receptor 2 Gene><Fostering><Genotype><Goals><Health><Health system><Hematopathology><Hospitals><Human><Image Analyses><Image Analysis><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Situ Hybridization><Induction Therapy><Institution><International><Intrahepatic Cholangiocarcinoma><Intrahepatic Cholangiocellular Carcinoma><Investigators><KGFR Gene><KSAM-1><Keratinocyte Growth Factor Receptor Gene><Knowledge><Leadership><Liquid substance><Malignant Neoplasms><Malignant Tumor><Medical><Metastasis><Metastasis to bone><Metastasize><Metastatic Cancer to the Bone><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Bone><Metastatic Tumor><Metastatic Tumor to the Bone><Metastatic malignant neoplasm to bone><Methods><Mission><Modern Man><NCI Organization><NEOADJ><National Cancer Institute><Neoadjuvant><Neoadjuvant Therapy><Neoadjuvant Treatment><Neoplasm Metastasis><New Jersey><Newsletter><Nucleic Acids><Osseous metastasis><Outcome><Pathologist><Pathology><Patients><Peripheral Cholangiocarcinoma><Persons><Phenotype><Population><Publications><Recommendation><Research><Research Personnel><Research Specimen><Researchers><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Scientific Publication><Scientist><Secondary Neoplasm><Secondary Tumor><Secondary cancer of bone><Secondary malignancy of bone><Secondary malignant neoplasm of bone><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Skeletal metastasis><Societies><Specimen><TK14><Technology><Testing><Therapeutic><Tissue Arrays><Tissue Chip><Tissue Microarray><Tissue Procurements><Tissue Sample><Tissues><Training><Translational Research><Translational Science><Trust><Underrepresented Groups><Underrepresented Populations><Universities><University Hospitals><Writing><Wuhan coronavirus><accredited><androgen independent prostate cancer><androgen indifferent prostate cancer><androgen insensitive prostate cancer><androgen resistance in prostate cancer><androgen resistant prostate cancer><anti-cancer research><biobank><biologic><biorepository><bone neoplasm secondary><calcification><cancer in the colon><cancer metastasis><cancer research><castration resistant CaP><castration resistant PCa><castration resistant prostate cancer><college><collegiate><community engagement><computer imaging><computer-assisted instruction><computer-based education><computer-based instruction><computer-based learning><computer-based training><computerized data processing><consultation><coronavirus disease 2019 virus><coronavirus disease-19 virus><data mining><data processing><datamining><depository><design><designing><digital><digital education><digital imaging><digital learning><e-Consent><eConsent><eLearning><electronic consent><electronic learning><engagement with communities><fluid><hCoV19><hormone refractory prostate cancer><image evaluation><image interpretation><improved><in situ Hybridization Genetics><in situ Hybridization Staining Method><induction therapies><innovate><innovation><innovative><internet-assisted education><internet-based training><intrahepatic bile duct carcinoma><liquid><malignancy><meeting><meetings><molecular imaging><molecule imaging><multimedia learning><nCoV2><necropsy><neoplasm/cancer><new technology><news><novel technologies><on-line education><on-line learning><online education><online learning><operation><operations><phenotypic biomarker><phenotypic marker><podcast><posters><postmortem><preservation><programs><prostate cancer resistant to androgen><public health relevance><repository><research study><sample collection><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social media><social role><soft tissue><specimen collection><success><support network><technology-enhanced learning><translation research><translational cancer research><translational investigation><trend><tumor><tumor cell metastasis><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people><virtual learning><web site><web-based instruction><web-based training><website><whole slide imaging>