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Principal Investigator: Daniel K Sodickson
Organization: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
Fiscal Year: 2020
Award: $772,877
Funding agency: National Institute of Biomedical Imaging and Bioengineering
PROJECT SUMMARY
Competitive Revision to P41 EB017183
The Center for Advanced Imaging Innovation and Research (CAI2R) pursues a mission of bringing people
together to create new ways of seeing. The work of our Center has been focused on creating new paradigms
for the acquisition, reconstruction, and interpretation of biomedical images, and on implementing new
collaboration models in order to translate these developments rapidly into clinical practice.
In the proposed Competitive Revision, we will apply our experience in working with biomedical images and
other signals to a new collaboration, aimed at the urgent need for COVID-19 testing.
Parent Grant Summary
The world of biomedical imaging is changing, and CAI2R has been at the forefront of that change. Tasks
that were once the sole domain of meticulously-engineered imaging hardware are now beginning to be
accomplished in software, increasingly informed by diverse arrays of inexpensive auxiliary sensors. Information
once pursued through the laborious acquisition of carefully separated image datasets is now being derived
from newly integrated, and richly quantitative, data streams. In keeping with these themes, our Center will be
organized around the following four Technology Research and Development (TR&D) projects going forward:
1. Reimagining the Future of Scanning: Intelligent image acquisition, reconstruction, and analysis.
2. Unshackling the Scanners of the Future: Flexible, self-correcting, multisensor machines.
3. Enriching the Data Stream: MRI and PET in concert.
4. Revealing Microstructure: Biophysical modeling and validation for discovery and clinical care.
Competitive Revision Summary
With the appearance of COVID-19, the world changed suddenly. The need for definitive but also broadly
available COVID-19 testing is clear, and is identified as a top priority in the Notice of Special Interest (NOT-EB-
20-008) to which this proposal responds. In this project, we will partner with colleagues in chemical
engineering and virology to develop, evaluate, and deploy a new electrochemical device for multifaceted point-
of-care or home-based COVID-19 testing. The device will use molecular surface imprinting to create a gold
surface sensitive to SARS-CoV-2 spike proteins and other analytes of interest. Sensitive solid-state
electronics will then detect the presence of these analytes in patient samples, ultimately allowing rapid and
simultaneous assessment of COVID-19 infection, immunity and severity. Specific Aims of the Competitive
Revision are as follows:
1. Prototype. We will test whether a COVID-19 signal may already be obtained using our best current
imprinting methods and electronic detection circuitry.
2. Characterize. We will use biobanked patient samples to establish sensitivity, specificity, and limits of
detection (LOD) of our initial prototype for COVID-19, as opposed to other common viruses.
3. Optimize and iterate. Informed by Aims 1 and 2, we will develop optimized electronics, surface imprinting
protocols, and measurement strategies to improve sensitivity and specificity.
4. Evaluate and distribute. We will test designs with promising performance prospectively in a cohort of
subjects presenting for testing at NYU, and will compare results with standard RT-PCR COVID-19 testing,
with an eye towards FDA approval, commercialization, and broader distribution.
Terms: <2019 novel coronavirus><2019-nCoV><Accidents><Accuracy of Diagnosis><Antibodies><Appearance><Bedside Testings><Biomedical Technology><Blood Sample><Blood specimen><COVID-19><COVID-19 epidemic><COVID-19 pandemic><COVID19><COVID19 epidemic><COVID19 pandemic><Cancers><Cell Communication and Signaling><Cell Signaling><Chemical Engineering><Chemicals><Clinical><CoV S protein><CoV glycoprotein S><CoV spike glycoprotein><CoV spike protein><Collaborations><Computer software><Coronavirus glycoprotein S><Coronavirus spike protein><Country><Data><Data Set><Dataset><Detection><Development><Devices><Diagnosis><Diagnostic tests><Disease><Disorder><ELISA><Electronics><Engineering><Enzyme-Linked Immunosorbent Assay><Evaluation><Eye><Eyeball><Future><Goals><Gold><H-bond><Health><Home><Home environment><Human><Hydrogen Bonding><Image><Imaging technology><Immune Markers><Immune response><Immunity><Immunologic Markers><Immunological response><Infection><Inflammatory><Intelligence><Intracellular Communication and Signaling><MR Imaging><MR Tomography><MRI><Macromolecular Structure><Magnetic Resonance Imaging><Malignant Neoplasms><Malignant Tumor><Measurement><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mercaptans><Mercapto Compounds><Methods><Mission><Modeling><Modern Man><Molecular><Molecular Structure><Monitor><Musculoskeletal Diseases><NIBIB><NMR Imaging><NMR Tomography><Nasal><Nasal Passages Nose><National Institute of Biomedical Imaging and Bioengineering><Nervous System Diseases><Neurologic Disorders><Neurological Disorders><Nose><Nuclear Magnetic Resonance Imaging><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathology><Patients><Performance><Polymerase Chain Reaction><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Printing><Process><Proteins><Protocol><Protocols documentation><Rad.-PET><Research><Respiratory System, Nose, Nasal Passages><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Saliva><Sampling><Scanning><Sensitivity and Specificity><Severe acute respiratory syndrome coronavirus 2><Severities><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Software><Specificity><Sulfhydryl Compounds><Surface><Surface Properties><Surface Proteins><Swab><Technology><Testing><Thiols><Time><Transistors><Translating><Validation><Viral><Viral Diseases><Viral Gene Products><Viral Gene Proteins><Viral Proteins><Virus><Virus Diseases><Work><Wuhan coronavirus><Zeugmatography><base><bio-imaging><biobank><bioimaging><biological signal transduction><biomedical imaging><biophysical model><biorepository><blind><clinical care><clinical practice><cohort><commercialization><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus S protein><coronavirus disease 2019><coronavirus disease 2019 epidemic><coronavirus disease 2019 pandemic><coronavirus spike glycoprotein><covalent bond><cytokine><data streams><design><designing><developmental><diagnostic accuracy><electrical property><electronic device><experience><flexibility><flexible><host response><imaging><immune-based biomarkers><immunological biomarkers><immunological markers><immunoresponse><imprint><improved><innovate><innovation><innovative><interest><malignancy><member><musculoskeletal disorder><neoplasm/cancer><nervous system disorder><neurological disease><novel imaging technique><novel imaging technology><parent grant><point of care><point of care testing><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><prospective><prototype><reconstruction><response><scale up><sensor><solid state electronics><sulfhydryl group><tech development><technological research and development><technology development><technology research and development><tool><viral infection><virology><virus infection><virus protein><virus-induced disease><voltage>