Animal Core

NIH Pandemic-Era Grants

Pandemic Era Grants

2023

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Principal Investigator: Stephen Mark Tompkins
Organization: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Fiscal Year: 2023
Award: $390,290
Funding agency: National Institute of Allergy and Infectious Diseases

Summary/Abstract
Robust animal models of coronavirus infection are required for pre-clinical assessment of candidate vaccines
and therapeutic antibodies to prevent coronavirus infection and disease. The goal of the Animal Model Core
is to provide a central resource of animal models and virological tools to assess the effectiveness of vaccines
and antibody therapies against betacoronaviruses in multiple animal models of infection. An experienced team
of investigators will utilize established hamster, mouse, and ferret models of betacoronavirus infection to
determine the efficacy of candidate therapeutic monoclonal antibodies (mAbs) developed by Project 1 and
vaccines developed by Project 2. Pre-immune and transmission models will be utilized to stringently test the
lead candidate vaccines. The Animal Model Core will also establish novel animal infection models with SARS-
CoV-2 variant viruses, and a novel ferret model of OC43 embecovirus infection. The Animal Model Core will
also complete virus neutralization assays for SARS-CoV and MERS CoV for all PLUTO investigators,
centralizing resources for these viruses, eliminating redundant biosafety and Select Agent approvals. The
Animal Model Core will serve as an innovative resource to assess efficacy of leading vaccine and mAb
candidates for the PLUTO program through the following three Specific Aims. 1) Establish and maintain
animal models of sarbecovirus and merbecovirus infection. 2) Establish and maintain coronavirus pre-immune
animal models. 3) Expand and improve animal models of embecovirus and sarbecovirus infection. These
complementary aims will enable rigorous assessment of vaccines and mAbs developed by the PLUTO
Projects and develop new animal models of betacoronavirus infection for the project and respiratory virus
research community. The novel pre-immune models will also provide data and samples to improve
understanding of the impact of pre-existing betacoronavirus immunity on subsequent vaccination and infection.
The outcomes of the Animal Model Core will have a positive impact on the success of the PLUTO program
and provide novel information and research tools for the broader research community.

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