Document text
Principal Investigator: Michael Cohen-Wolkowiez
Organization: DUKE UNIVERSITY
Fiscal Year: 2020
Award: $20,162,334
Funding agency: National Institute on Minority Health and Health Disparities
ABSTRACT
There is an urgent need to reduce disparities in COVID-19 associated morbidity and mortality outcomes in
historically marginalized and vulnerable populations disproportionately affected by the COVID-19 pandemic. To
address this need the Rapid Acceleration of Diagnostics for Underserved Populations (RADx-UP) program will
support Community-Engaged Testing Research Projects and Social, Ethical and Behavioral Implications
(SEBI) Research Projects to understand SARS-CoV-2 infection patterns and increase access and
effectiveness of diagnostic methods in underserved and/or vulnerable populations. The Duke Clinical Research
Institute (DCRI), the UNC Center for Health Equity Research (CHER), and Community-Campus Partnerships
for Health (CCPH) propose to serve as the Coordination and Data Collection Center (CDCC) to provide
management, direction, and overall coordination of the RADx-UP consortium. Together, our multidisciplinary
experience in project coordination; COVID-19 thought leadership; regulatory science; community engagement;
health equity research; social justice; adult and child research; statistics; data science; and clinical research
informatics will advance the objectives of the projects in the RADx-UP Program. Our overarching goal is to
implement a community-centered approach and establish an effective, flexible, participatory, and sustainable
CDCC that will serve as the infrastructure to maximize the community impact of projects in the RADx-UP
Program. To achieve this vision, we will establish a program framework comprised of four cores. Our
Administration and Coordination Core, in collaboration with NIH scientific staff, will facilitate the work of the
RADx-UP Program in overarching administrative management. The COVID-19 Testing Core will advise and
guide COVID-19 testing protocols; curate emergent testing data; and administer the Rapid Pilot Studies
Program. The Community and Health System Engagement Core will support a community of practice across
the RADx-UP Program; provide support in exchanging best practices across communities on recruitment,
engagement, and retention of study participants; and coordinate the dissemination of study findings from
RADx-UP projects. The Data Science and Biostatistics Core will manage data collection, integration, and
sharing for the RADx-UP Program including merging and harmonization of multiple and diverse data sources
and provide data standards, data collection design, and biostatistics consulting services. The RADx-UP CDCC
goals will be met using established infrastructure and subject matter experts and will be customized to meet
the variable needs of the RADx-UP community. Using the highest research standards, our team will
accomplish the goals set out by the NIH in managing this critically important collaborative effort.
Terms: <0-11 years old><2019 novel coronavirus><2019-nCoV><21+ years old><Acceleration><Address><Administrative Management><Adult><Adult Human><Affect><Back><Behavioral><Biometrics><Biometry><Biostatistics><Biostatistics Core><COVID-19><COVID-19 epidemic><COVID-19 pandemic><COVID19><COVID19 epidemic><COVID19 pandemic><Cessation of life><Child><Child Youth><Children (0-21)><Clinical Research><Clinical Study><Collaborations><Communities><Community Health Systems><Community of Practice><Consult><Custom><Data><Data Banks><Data Collection><Data Science><Data Sources><Databanks><Death><Diagnostic><Diagnostic Method><Diagnostic Procedure><Diagnostic Technique><Dorsum><Effectiveness><Ensure><Ethics><Funding><Future><Goals><Health><Inequality><Infection><Informatics><Infrastructure><Investigators><Leadership><Morbidity><Morbidity - disease rate><NIH><National Institutes of Health><Office of Administrative Management><Outcome><Participant><Pattern><Pilot Projects><Plant Roots><Population Programs><Protocol><Protocols documentation><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Institute><Research Personnel><Research Project Grants><Research Projects><Research Support><Researchers><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Science><Scientific Advances and Accomplishments><Services><Severe acute respiratory syndrome coronavirus 2><Sight><Social Justice><Structure><Testing><Underserved Population><United States National Institutes of Health><Universities><Virus><Vision><Vulnerable Populations><Work><Wuhan coronavirus><adulthood><children><childrens'><community center><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019><coronavirus disease 2019 epidemic><coronavirus disease 2019 pandemic><data depository><data diversity><data management><data repository><data standardization><data standards><data warehouse><design><designing><disparity in health><disparity reduction><diverse data><ethical><experience><flexibility><flexible><health disparity><health equity><improved><infrastructure development><interest><lens><lenses><mortality><multidisciplinary><pandemic><pandemic disease><pilot study><prevent><preventing><programs><recruit><reduce disparity><root><scientific accomplishments><scientific advances><social><statistics><under served population><underserved people><visual function><vulnerable group><youngster>