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Principal Investigator: Daniel David BUCHANAN
Organization: UNIVERSITY OF MELBOURNE
Fiscal Year: 2024
Award: $1,619,489
Funding agency: National Cancer Institute
PROJECT SUMMARY / ABSTRACT
The international, multi-site Colon Cancer Family Registry has established a cohort of approximately 37,400
colorectal cancer cases and their relatives, who are at increased risk of colorectal and other cancers, from over
10,800 families from the USA, Canada, and Australia. Existing standardized data from members include baseline
epidemiologic and follow-up questionnaires, clinical data, blood/buccal samples, tumor blocks, comprehensive
genotype data, including genome-wide association study (GWAS) data on population-based case- and control-
probands, extensive molecular characterization of the colorectal tumors, and genetic characterization of
participants for the cancer predisposing Lynch syndrome. All participants have been asked to participate in 5-
yearly follow-up, and with an 87% participation, have contributed a total of 470,000 person-life years and 1,000
incident colorectal and 4,700 incident other cancers. The resource has been used for 500 publications (132 in
the current project period) and 288 projects led by external investigators (56 in the past project period). In this
application, we seek funding for continued support of the cohort infrastructure, to continue follow-up of
participants, and to enhance the cohort with innovative characterization of value to future research on the
prevention, etiology and prognosis of CRC. We propose the following specific aims:
Aim 1: Preserve and encourage continued utilization of the Cohort and its resources
Aim 2: Update the cohort by follow-up of cohort members
Aim 3: Maintain and enhance the biorepository
Aim 4: Characterize incident colorectal cancers
Aim 5: Enhance and revitalize the cohort by recruiting the next generation
Aim 6: Enhance the cohort with microbiome data
Maintaining and enhancing our core infrastructure will facilitate our broad research agenda and will ensure that
the Colon Cancer Family Registry Cohort is increasingly valuable to research science and ultimately the public’s
health.
Terms: <0-11 years old><18 year old><18 years of age><Active Follow-up><Address><Age><Agreement><Alcohol Chemical Class><Alcohols><Australia><B-raf-1><BRAF><BRAF gene><Blood><Blood Reticuloendothelial System><C-K-RAS><COVID-19 affected><COVID-19 consequence><COVID-19 effect><COVID-19 impact><COVID-19 impacted><Calibration><Canada><Cancer Survivor><Cancer Susceptibility Gene><Cancer-Predisposing Gene><Cancers><Causality><Certification><Cessation of life><Characteristics><Child><Child Youth><Children (0-21)><Clinical><Clinical Data><Cohort Studies><Colon or Rectum><Colorectal><Colorectal Cancer><Colorectal Neoplasms><Colorectal Tumors><Communities><Computer Security><Concurrent Studies><DNA><Data><Death><Deoxyribonucleic Acid><Development><Diagnosis><Disease><Disorder><Drugs><E coli><E. coli><Electronic Health Record><Ensure><Environmental Factor><Environmental Risk Factor><Epidemiology><Equipment><Escherichia coli><Etiology><Event><Familial Nonpolyposis Colon Cancer><Family><Family Medical History><Family Medical History Epidemiology><Family history of><Family member><Funding><GWA study><GWAS><Gases><Generations><Genes><Genetic><Genetic Alteration><Genetic Change><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic defect><Genetic predisposing factor><Genetic propensity><Genotype><Germ Lines><Germ-Line Mutation><Germline Mutation><Grant><HNPCC><Health><Hereditary Colo-rectal Endometrial Cancer Syndrome><Hereditary Colorectal Endometrial Cancer Syndrome><Hereditary Defective Mismatch Repair Syndrome><Hereditary Mutation><Hereditary Non-Polyposis Colon Cancer><Hereditary Nonpolyposis Colo-rectal Cancer><Hereditary Nonpolyposis Colo-rectal Neoplasms><Hereditary Nonpolyposis Colon Cancer><Hereditary Nonpolyposis Colorectal Cancer><Hereditary Nonpolyposis Colorectal Neoplasms><History><Human><Individual><Industry Standard><Informatics><Infrastructure><Inherited Predisposition><Inherited Susceptibility><International><Intestinal><Intestines><Investigators><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><KRAS><KRAS2><KRAS2 gene><Ki-RAS><LS/HNPCC><Large Bowel Tumor><Large Intestine Neoplasm><Large Intestine Tumor><Life><Liquid substance><Lynch Syndrome><MLH1><MLH1 gene><Maintenance><Malignant Neoplasms><Malignant Tumor><Medical Records><Medication><Methylation><Minority><Mismatch Repair><Modern Man><Molecular><Mouth microbiome><MutL E Coli Homolog 1><MutL E. Coli Homolog 1><Mutation><Nitrogen><Oncogene K-Ras><Operative Procedures><Operative Surgical Procedures><Participant><Pathology><Pathology Report><Patients><Persons><Pharmaceutical Preparations><Phylogenetic Analysis><Phylogenetics><Post-Replication Mismatch Repair><Prevention><Preventive><Procedures><Prognosis><Public Health><Publications><Questionnaires><RAFB1><RASK2><Recording of previous events><Records><Reporting><Research><Research Personnel><Research Resources><Research Specimen><Researchers><Resource Sharing><Resources><Risk><Risk Factors><Role><Sampling><Scanning><Science><Scientific Publication><Screening Result><Screening for cancer><Secure><Site><Slide><Smoking><Somatic Mutation><Specimen><Standardization><Surgical><Surgical Interventions><Surgical Procedure><Survey Instrument><Surveys><Syndrome><THC co-use><THC use><Test Result><Testing><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Update><Work><active followup><age 18 years><ages><anti-cancer research><bacteria in the gut><biobank><biorepository><bowel><cancer diagnosis><cancer registry><cancer research><cancer type><cannabis use><causation><cloud storage><cloud-based storage><cohort><colon cancer family registry><colon carcinogenesis><colorectal cancer risk><colorectal carcinogenesis><colorectal neoplasia><colorectum><coronavirus disease 2019 consequence><coronavirus disease 2019 effect><coronavirus disease 2019 impact><coronavirus disease-19 impact><cost><data harmonization><data sharing><data standardization><data standards><database of Genotypes and Phenotypes><dbGaP><design><designing><developmental><digital><disease causation><drug/agent><early cancer detection><eighteen year old><eighteen years of age><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><environmental risk><epidemiologic><epidemiological><familial colorectal cancer><fecal microbial community><fecal microbiota><fluid><follow up><follow-up><followed up><followup><gene testing><gene-based testing><genetic etiology><genetic mechanism of disease><genetic risk factor><genetic testing><genetic vulnerability><genetically predisposed><genome mutation><genome wide association><genome wide association scan><genome wide association studies><genome wide association study><genomewide association scan><genomewide association studies><genomewide association study><genomic classifier><genomic signature><germ-line defect><germline variant><grandchild><gut bacteria><harmonized data><hereditary colorectal cancer><hereditary non-polyposis colo-rectal cancer><hereditary non-polyposis colorectal cancer><high risk><histories><inherited factor><innovate><innovation><innovative><kids><large bowel neoplasm><liquid><malignancy><marijuana use><member><microbiome><neoplasm registry><neoplasm/cancer><next generation><oral microbial community><oral microbiome><oral microbiota><oral microflora><patient portal><population based><preservation><prevent><preventing><proband><public health relevance><recruit><screening><screening cancer patients><screenings><shareable platform><sharing platform><social role><somatic variant><surgery><survivorship><system security><tumor><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog><v-raf Murine Sarcoma Viral Oncogene Homolog B1><virtual><waist circumference><web site><website><whole genome association analysis><whole genome association studies><whole genome association study><youngster>