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Principal Investigator: Niketa A. Patel
Organization: JAMES A. HALEY VA MEDICAL CENTER
Fiscal Year: 2024
Funding agency: Veterans Affairs
This application is for Research Career Scientist award for Niketa A. Patel, Ph.D., 8/8th VA, PI of active
VAMR award, national peer-reviewed research support since 2005, office (Room 303-4) and
laboratory (Suites 300 and 303) in James A. Haley Veterans’ Hospital Research Service space. I have
developed and established a strong program in cellular and molecular mechanisms of metabolic
diseases. My research integrates human studies (translational relevance to human
physiology/pathophysiology), in vitro cell studies (for mechanistic studies of alternative splicing and
role of noncoding RNA; elucidation of cause vs. effect), in vivo rodent studies (for determining whole
body systemic impact of novel inhibitors and stabilizers) and cutting-edge transcriptomics (such as
RNAseq global analysis of coding and noncoding RNA and cellular signaling). I have successfully
carved a niche in integrating RNA biology with signaling in biologically relevant systems and
understanding how it may be a cause or consequence of a disease. Overall, my projects focus on the
role of adipose as an endocrine organ and impact of its secretome on the metabolic processes in the
body. My research was pivotal to demonstrate that the adipose stem cells’ niche is altered in obesity.
61-83% of DoD beneficiaries and 78% of VA beneficiaries are over-weight or obese, a significantly
higher percent compared to general population (VA/DoD Clinical guideline, 2014). With over 9.2
million beneficiaries, the cost of obesity and its related diseases exceeds $1.7 billion annually for the
VA while total US expenditures has risen to $254 billion annually. An important application of my
research is development of exosomes derived from human adipose stem cells as treatment
for traumatic brain injury (TBI) related sequelae. TBI significantly affects the quality of life of veterans
and military readiness of our country. A significantly higher percent (22%) of US soldiers and veterans
who served in Iraq and Afghanistan (OEF/OIF) have brain injuries compared to those from Vietnam
era (12%). The VA projects the 10-year (2016–2025) economic costs of TBI to be $2.2 billion with
$0.5 billion for OEF/OIF veterans (CRS report on TBI, 2015). The exosomes from human adipose-
derived stem cells provide a novel, cell-free regenerative approach for treatment of chronic effects of
TBI. My lab’s recent publications (Sparks et al, Journal of Biological Chemistry 2019; Shi et al, Cell
Chemical Biology, 2019; Patel et al, Journal of Neuroinflammation 2018) showcasing extensive work
with cutting edge technologies and development of new therapeutics has received immense national
and international recognition. These publications follow my career’s trend of publishing translationally
relevant, mechanistically strong research in high-impact journals. I hold five USPTO patents with VA
asserted rights which were developed as part of my VA duties as a scientist. I have been an invited
speaker at national and international scientific meetings. I serve my local VA by serving on IACUC,
SRS and R&D committees since 2007 and as Director of JAHVH molecular core facility. At SRS, I
have served as vice-chair (2012-14) and Chair (2015-2019). I serve at the national level in the VA
Career Development review committee, VA ENDA Merit review Committee and NIH CADO
committees. At my affiliate University of South Florida, I teach in the graduate and medical courses
since 2002. I have mentored undergraduate, graduate and medical students who have established
successful careers. Over the years, I have collaborated with VA and non-VA, clinicians and scientists
which has resulted in publications and national grants. Overall, I have contributed significantly to
JAHVH research mission of conducting cutting-edge translational research to boost healthcare of
Veterans and contributing to the long-term research goals of VAMC.
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