Document text
Principal Investigator: MATHEW S MAURER
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
Fiscal Year: 2020
Award: $176,033
Funding agency: National Heart Lung and Blood Institute
Project Summary
COVID-19 is a global pandemic that disproportionately affects minority older adults with cardiac disease and
multiple chronic conditions. Densely populated urban centers with a high proportion of socioeconomically
disadvantaged persons, including New York City (NYC) and Boston, are most impacted by COVID-19. SCAN-
MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations, R01HL139671) is a
NHLBI funded, prospective cohort study that enrolled 123 of a target 800 Black or Caribbean Hispanic
participants over the age of 60 years with heart failure prior to the mandatory recruitment pause for the
pandemic. The profile of the SCAN-MP participant matches those known to be at highest risk from COVID-
19. In this application, we propose to leverage the successful recruitment and retention techniques of the
SCAN-MP infrastructure to advance our understanding of the prevalence of SARS CoV-2 infection and
disentangle the demographic, social, and environmental factors known to be associated with infection. While
mitigation is the primary public health strategy to address the spread of COVID-19, it may be particularly
challenging for those with resource limitations or those who live in close physical proximity to others to comply
with CDC recommendations, perhaps accounting for the observed increase in infection rates. Successful
emergence from the pandemic will depend upon evidence of prior SARS CoV-2 infection in the population.
Given that asymptomatic infection is common, serologic testing will likely play a critical role in the next phase
of recovery. Serologic testing has been validated at Columbia University with a highly sensitive and specific,
quantitative ELISA-based assay to detect antibodies to SARS-CoV-2 that we propose to leverage in this
study. Our objectives are to (1) define the proportion of SCAN-MP participants with evidence of prior COVID-
19 infection by antibody testing, (2) determine the capacity of SCAN-MP participants to comply with CDC
mitigation recommendations. We will then explore how infection rate and mitigation compliance interact with
socio-economic factors such as income and living conditions, as well as measures of health literacy,
trust/engagement in the health system, and perceived discrimination. We will explore whether the presence
and/or titer of antibodies specific for SARS CoV-2 virus will be associated with future COVID-19 infection as
well as adverse outcomes (hospitalizations and mortality) over a one-year time period. We are uniquely
positioned to perform these studies quickly given our ability to recruit an urban, minority cohort with cardiac
disease at high risk for COVID-19 morbidity/mortality, expertise in the performance of serologic testing for
antibodies to SARS CoV-2, and established expertise in community engaged research. Successful
completion of these Aims has the potential to inform implementation of mitigation strategies in high-risk
populations and contribute important data useful for the resolution of the COVID-19 pandemic.
Terms: <2019 novel coronavirus><2019-nCoV><Accounting><Address><Adherence><Admission><Admission activity><Affect><African American><African Caribbean><Afro American><Afroamerican><Age><Age-Years><Amyloidosis><Antibodies><Antibody titer measurement><Area><Assay><Bioassay><Biochemical><Biologic Assays><Biological Assay><Black Populations><Boston><CDC><COVID-19><COVID-19 epidemic><COVID-19 pandemic><COVID19><COVID19 epidemic><COVID19 pandemic><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Failure Congestive><Cardiovascular Diseases><Caribbean Hispanic><Cellular biology><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Cessation of life><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Cities><Clinical><Cognitive Discrimination><Cohort Studies><Communities><Concurrent Studies><Congestive Heart Failure><Data><Death><Demographic Factors><Diabetes Mellitus><Discrimination><ELISA><Economic Factors><Economic Income><Economical Factors><Economical Income><Education><Educational aspects><Elderly><Enrollment><Environmental Factor><Environmental Risk Factor><Enzyme-Linked Immunosorbent Assay><Funding><Future><Health><Health system><Heart Decompensation><Heart Diseases><Heart failure><Hispanic Populations><Hispanics><Hospital Admission><Hospitalization><Hypertension><Income><Individual><Infection><Infrastructure><LVEF><Latino Population><Left Ventricular Ejection Fraction><Masks><Measures><Medical center><Minority><Morbidity><Morbidity - disease rate><NHLBI><National Heart, Lung, and Blood Institute><New York><New York City><Participant><Pathology><Patient Self-Report><Patients><Performance><Persons><Phase><Play><Population><Position><Positioning Attribute><Prevalence><Prospective cohort study><Provider><Public Health><RNA Viruses><Race><Racial Group><Racial Stocks><Recommendation><Recovery><Research><Research Resources><Resolution><Resources><Respiratory Failure><Role><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Self-Report><Serologic tests><Serological Tests><Severe acute respiratory syndrome coronavirus 2><Socioeconomically disadvantaged><Spanish Origin><Symptoms><Techniques><Testing><Time><Trust><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Universities><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Virus><Wuhan coronavirus><advanced age><adverse consequence><adverse outcome><ages><amyloid disease><antibody titering><base><black American><black Caribbean><black carib><cardiac failure><cardiovascular disorder><cell biology><chronic heart failure><chronic kidney disease><co-morbid><co-morbidity><cohort><comorbidity><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019><coronavirus disease 2019 epidemic><coronavirus disease 2019 pandemic><diabetes><disadvantaged population><elders><enroll><environmental risk><geriatric><health literacy><heart disorder><high blood pressure><high risk><high risk group><high risk population><hispanic community><hyperpiesia><hyperpiesis><hypertensive disease><infection rate><late life><later life><male><minority subjects><mortality><multimorbidity><multiple chronic conditions><nuclear imaging><older adult><older person><pandemic><pandemic disease><preservation><prospective><pulmonary failure><rate of infection><recruit><respiratory insufficiency/failure><screening><senior citizen><serology><social factors><social role><socio-economic><socio-economic disadvantage><socio-economically><socio-economically disadvantaged><socio-economically underprivileged><socioeconomic disadvantage><socioeconomically><socioeconomically underprivileged><socioeconomics><urban dwelling>