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Principal Investigator: Olivier Elemento
Organization: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
Fiscal Year: 2022
Award: $147,304
Funding agency: National Institute of Allergy and Infectious Diseases
Data Management Core
Principal Investigator: Olivier Elemento, PhD.
Co-I: Zhengming Chen, PhD
Abstract
This Core will provide bioinformatics expertise and support with data integration and analyses. The Core will
serve three main goals. First, it will provide central data storage and data management ensuring that the integrity
of the data of the Projects and Cores is protected using appropriate safeguards. Second, it will assure data and
metadata sharing and dissemination through the ImmPort, database or other databases as recommended by
NIAID. Third, it will support Projects 1 and 2, by performing state of the art statistical analyses.
Specifically, the Core will be responsible for: 1) Deploying an informatics platform for data ingestion, processing
and sharing using a cloud-based platform. The platform is capable of ingesting data from all participant sites and
will interface with the clinical data based (REDCap) and sample tracking databases (OpenSpecimen) using
appropriate safeguards. In addition, the Data Management Core will deploy automated quality control scripts to
detect potential batch effects and low-quality samples. Importantly the core will use the ImmPort data model for
data storage, thus standardizing data relations and facilitating data dissemination; 2) Perform statistical and
integrative analyses of diverse datasets using state-of-the-art univariate and multivariate statistical as well as
machine learning techniques. This approach will optimize the use of resources and will facilitate integration and
synergy among all projects.
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