Molecular imaging of viral infections

NIH Pandemic-Era Grants

Pandemic Era Grants

2023

↗ Live URL (may be dead)

Document text

Principal Investigator: Dima A Hammoud
Organization: CLINICAL CENTER
Fiscal Year: 2023
Funding agency: NIH Clinical Center

Progress:
HIV project: We are in the stage of optimizing our animal model of Gp120 expressing HEK293 tumors implanted in nude mice in comparison to wild type tumors. We have validated and labeled multiple nanobodies against GP120 with 18F and started PET imaging. Early results are encouraging and we are currently optimizing site specific binding. Results are pending.

Ebola and other high consequence viral infection: We are collaborating with the Integrated research facility on multiple studies evaluating Nipah, Lassa, Marburg, Covid-19 and Ebola infections. 

Sars-Cov-2 project: We have finished our experiments and are currently writing the manuscript.

Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><2019-nCoV S protein><2019-nCoV spike glycoprotein><2019-nCoV spike protein><ACE2><AIDS Virus><Acids><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Acute Lung Injury><Acute Pulmonary Injury><Address><Affinity><After Care><After-Treatment><Aftercare><Albumins><Animal Model><Animal Models and Related Studies><Animals><Assay><Athymic Mice><Athymic Nude Mouse><Binding><Binding Sites><Bioassay><Biologic Assays><Biological Assay><Blood><Blood Reticuloendothelial System><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Brain><Brain Nervous System><CAT scan><CLP model><CLP mouse model><CNS Injury><COVID-19><COVID-19 S protein><COVID-19 infection><COVID-19 spike glycoprotein><COVID-19 spike protein><COVID-19 virus><COVID-19 virus infection><COVID19><COVID19 S protein><COVID19 infection><COVID19 spike glycoprotein><COVID19 spike protein><COVID19 virus><CT X Ray><CT Xray><CT imaging><CT scan><CV-19><CV19><Cecal ligation perforation><Cell Body><Cells><Characteristics><CoV-2><CoV2><Collaborations><Combining Site><Computed Tomography><DNA Molecular Biology><Development><Diagnosis><Diagnostic><Disease><Disease Progression><Disorder><Down-Regulation><Drug Kinetics><Dysfunction><EBOV><Ebola><Ebola virus><Ebola-like Viruses><Encephalon><Endothelium><Extravasation><Frankfurt-Marburg Syndrome Virus><Functional disorder><Genes><Goals><HIV><HIV Envelope Glycoprotein gp120><HIV Envelope Protein gp120><HIV Infections><HIV env Protein gp120><HTLV-III Infections><HTLV-III gp120><HTLV-III-LAV Infections><Human><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Image><Implant><Infection><K-18><K-18 conjugate><K18><K18 combination><KO mice><Knock-out Mice><Knockout Mice><LAV-HTLV-III><Label><Lassa fever virus><Lassa virus><Leakage><Ligands><Lipopolysaccharides><Lung><Lung Alveolar Epithelia><Lung Respiratory System><Lung damage><Lymphadenopathy-Associated Virus><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Manuscripts><Marburg><Marburg virus><Marburg-like Viruses><Marburgvirus><Measurement><Mediating><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mice><Mice Mammals><Modern Man><Molecular Biology><Molecular Interaction><Molecular Target><Murine><Mus><NMR Imaging><NMR Tomography><Nature><Nipah Virus><Nuclear Magnetic Resonance Imaging><Nude Mice><Null Mouse><Organ><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathology><Peripheral><Pharmacokinetics><Physiopathology><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Process><Proteins><Publishing><Pulmonary Pathology><Rad.-PET><Radiolabeled><Reactive Site><Receptor Protein><Recombinants><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 S protein><SARS-CoV-2 infection><SARS-CoV-2 spike glycoprotein><SARS-CoV-2 spike protein><SARS-CoV2><SARS-CoV2 S protein><SARS-CoV2 infection><SARS-CoV2 spike glycoprotein><SARS-CoV2 spike protein><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 S protein><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 spike glycoprotein><Severe acute respiratory syndrome coronavirus 2 spike protein><Severe acute respiratory syndrome related corona virus 2><Severities><Site><Spillage><Spleen><Spleen Reticuloendothelial System><Therapeutic Intervention><Tissues><Tomodensitometry><Type II Cell><Type II Epithelial Receptor Cell><Viral><Viral Diseases><Virus><Virus Diseases><Virus Replication><Virus-HIV><Wild Type Mouse><Writing><Wuhan coronavirus><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><Zeugmatography><alveolar epithelium><angiotensin converting enzyme 2><angiotensin converting enzyme II><aspirate><catscan><cecal ligation and perforation><cecal ligation and puncture><cecal ligation puncture><cecum ligation and puncture><cecum ligation puncture><central nervous system injury><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><corona virus disease 2019><coronavirus disease 2019><coronavirus disease 2019 S protein><coronavirus disease 2019 infection><coronavirus disease 2019 spike glycoprotein><coronavirus disease 2019 spike protein><coronavirus disease 2019 virus><coronavirus disease-19><coronavirus disease-19 virus><coronavirus infectious disease-19><developmental><ebolavirus><experiment><experimental research><experimental study><experiments><gp120><gp120 ENV Glycoprotein><gp120(HIV)><hCoV19><image-based method><imaging><imaging in vivo><imaging method><imaging modality><improved><in vivo><in vivo imaging><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><injured CNS><intervention therapy><lung injury><lung pathology><microPET/CT><model of animal><molecular imaging><molecule imaging><mouse model><murine model><nCoV2><nanobodies><nanobody><natural antibodies><non-contrast CT><non-invasive imaging><noncontrast CT><noncontrast computed tomography><noninvasive imaging><pathophysiology><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><post treatment><protection pathway><protective pathway><pulmonary><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><radiolabeling><radiologically labeled><receptor><research facility><response><sdAb><single domain antibodies><social role><tumor><viral infection><viral multiplication><viral replication><virus infection><virus multiplication><virus-induced disease><wildtype mouse>