Document text
Principal Investigator: HEATHER Hammond NELSON
Organization: UNIVERSITY OF MINNESOTA
Fiscal Year: 2024
Award: $2,660,848
Funding agency: National Cancer Institute
Abstract
The 10,000 Families Study (10KFS) will be a new, family-based cohort study in Minnesota, the ‘Land of 10,000
Lakes’. Due to our high incidence rates of hematologic malignancy (leukemia, lymphoma, and myelodysplastic
syndromes), we will focus our proposal on environmental exposures of concern that are possible hematologic
carcinogens with limited evidence in humans as defined by the International Agency for Research on Cancer
(IARC). This includes glyphosate, poly- and perfluoroalkyl substances (PFAS), and radon, all of which have
well-described geographic variation in prevalence in the state of Minnesota. During the UG3 phase, we will
evaluate innovative exposure assessment methodologies and recruit diverse participants into the 10KFS
cohort. Exposure assessment will include residential history, ambient measures in air and water at current
residence, as well as individual-level exposure assessed with silicone wearable bracelets, serum, hair, and
urine. Participants will be recruited from targeted counties that maximize the exposure distribution to our three
carcinogens of interest and include under-represented populations from rural and immigrant communities. We
will measure clonal hematopoiesis of indeterminate potential (CHIP), a precursor to heme malignancy, and
perturbations in immunity and epigenetics as our primary cancer-related outcomes in the UH3 phase. Our
target is to recruit 8,750 participants from 4,000 households to participate using recruitment strategies that
have been developed and pilot tested. Our central hypothesis is that PFAS, glyphosate and radon contribute to
increased hematologic malignancy specifically, and cancer incidence broadly, in Minnesota. Cancer incidence
will be determined via annual record linkage with the Minnesota Cancer Reporting System (MCRS) and the
Virtual Pooled Registry Cancer Linkage System. The scientific aims in the UG3 phase will be to: 1) evaluate
innovative exposure assessment methods for PFAS and glyphosate that can be easily implemented in a large
scale study and 2) describe the exposure burden in under-represented immigrant populations. We will
complete recruitment of the study population in the UH3 phase where the specific aims are to: 1) determine
whether levels of radon, glyphosate, and PFAS are associated with increased prevalence of CHIP and 2)
utilize epigenomics to test the hypotheses that radon, glyphosate and PFAS exposure are associated with
immune dysregulation and epigenetic signatures. Our community engagement will be conducted in partnership
with the non-profit research institute Hispanic Advocacy and Community Empowerment Through Research
(HACER), the Minnesota Freemasons and Order of the Eastern Star and community educators from the
Extension Center for Family Development. The results of this study will provide needed data to inform whether
these agents are hematologic carcinogens, it will address documented disparities in exposure that occur within
our state and provide a mechanism for community outreach and education concerning these exposures and
any potential cancer link.
Terms: <0-11 years old><21+ years old><Acceleration><Address><Adult><Adult Human><Advocacy><Age><Agriculture><Air><Ancillary Study><Automobile Driving><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Serum><Cancer Cause><Cancer Causing Agents><Cancer Center><Cancer Etiology><Cancers><Carcinogens><Cell Body><Cells><Chemicals><Child><Child Youth><Children (0-21)><Classification><Cohort Studies><Collection><Communities><Community Education><Community Health Education><Community Outreach><Concurrent Studies><County><Data><Development><Disparities><Disparity><Dysmyelopoietic Syndromes><Environmental Exposure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Exposure to><Family><Family Study><Ferroprotoporphyrin><Fingers><Funding><Germinoblastic Sarcoma><Germinoblastoma><Gold><Hair><Hematologic Agents><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Agents><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematology><Hematopoiesis><Hematopoietic Cancer><Hematopoietic Cellular Control Mechanisms><Heme><Heritability><High Prevalence><Hispanic><History><Household><Human><Hydrogen Oxide><IARC><Immigrant><Immigrant community><Immune><Immune Markers><Immunes><Immunity><Immunologic Markers><Incidence><Individual><International Agency for Research on Cancer><Iowa><Link><Long-term Follow-up><Longterm Follow-up><Lymphoma><Malignant Hematologic Neoplasm><Malignant Lymphoma><Malignant Neoplasms><Malignant Tumor><Measures><Methodology><Methods><Minnesota><Modern Man><Myelodysplastic Disease><Myelodysplastic Syndromes><N-(phosphonomethyl)glycine><Non-Hodgkin's Lymphoma><Nonhodgkins Lymphoma><Oncogens><Outcome><PFAS><Participant><Patient Recruitments><Pesticides><Phase><Poly-fluoroalkyl substances><Population><Prevalence><Prospective cohort><Protoheme><Racial Group><Radon><Recording of previous events><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Reporting><Research><Research Institute><Reticulolymphosarcoma><Risk><Risk Factors><Rn element><Role><Roundup><Rural><Rural Community><Serum><Si element><Silicon><Silicones><Smoldering Leukemia><System><Systematics><Technology><Testing><Time><Underrepresented Groups><Underrepresented Populations><Universities><Urine><Venous><Water><Wisconsin><adulthood><ages><bio-markers><biobank><biologic marker><biomarker><biorepository><blood cell formation><cancer registry><cancer risk><cancer type><carcinogenicity><cohort><community empowerment><community engagement><de novo mutation><de novo variant><developmental><driving><early biomarkers><early detection biomarkers><early detection markers><engagement with communities><epigenetically><epigenomics><ethnic minority><ethnic subgroup><ethnicity group><ferroheme><geographic difference><geographic variation><gliphosate><glyphosate><high risk><histories><immune-based biomarkers><immunological biomarkers><immunological markers><innovate><innovation><innovative><interest><kids><leukemia><long-term followup><longterm followup><malignancy><manufacture><microbiome><myelodysplasia><neoplasm registry><neoplasm/cancer><non-Hodgkins disease><oncogenic agent><participant recruitment><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><pilot test><polyfluorinated alkyl substances><polyfluoroalkyl substances><racial minority><racial population><racial subgroup><recruit><residence><residential building><residential site><rural area><rural location><rural region><social role><study population><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people><urban area><urban location><urban region><virtual><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><youngster>