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Principal Investigator: Melissa Hladek
Organization: JOHNS HOPKINS UNIVERSITY
Fiscal Year: 2024
Award: $195,390
Funding agency: National Institute of Diabetes and Digestive and Kidney Diseases
PROJECT SUMMARY/ ABSTRACT
Kidney transplantation (KT) is a growing treatment for older adults with end-stage renal disease (ESRD), but
there is vast heterogeneity in KT outcomes. Older adults are more likely to be listed as inactive (on the waitlist
but ineligible for KT), which is associated with increased waitlist mortality and worse post-surgical outcomes.
Those awaiting KT also experience depressive symptoms, pain, loss of physical function, and social isolation,
which can contribute to waitlist mortality and decrease chances of KT. As of April 2022, 94,249 people were
awaiting KT with an estimated 44% currently inactive. There is a critical need for enhanced models of care to
improve inactive waitlist outcomes. The purpose of this study is to adapt and pilot test the evidence-based
Community Aging in Place- Advancing Better Living for Elders (CAPABLE) intervention to address barriers for
KT waitlist activation which involve symptom burden, self-management, social support, health literacy, patient
activation and home function. CAPABLE equips older adults to age in their homes using person-directed
priorities and a strengths-based tailored approach by a nurse, occupational therapist and handy worker (PI:
Szanton, co-primary mentor). CAPABLE improves function, pain, depressive symptoms, and quality of life
while decreasing hospitalizations and nursing home admissions. CAPABLE also improves healthcare
engagement and self-efficacy which are key components to remaining active on the KT waitlist. Our adapted
CAPABLE–Transplant model will extend services to include options for internet access, training, patient portal
usage and patient-directed online social engagement to address the noted isolation. We hypothesize that
decreasing patient and clinician reported barriers will decrease time inactive on the KT waitlist status. We plan
to examine CAPABLE-Transplant among those with inactive KT waitlist status in a two-phase developmental
study leveraging partnership with the JHU Comprehensive Transplant Center and an ongoing, prospective NIA
R01-funded cohort study of individuals awaiting KT for recruitment (PI: McAdams-DeMarco, co-primary
mentor) through the following aims: (1) To develop an adaptation of CAPABLE targeting those currently KT
inactive, (2) To iteratively refine the CAPABLE -Transplant prototype for those currently KT inactive and, (3)
To pilot test the CAPABLE-Transplant intervention in a 30 person 1:1 randomized waitlist control trial delivered
over 16 weeks with outcomes (e.g. waitlist status, symptom burden, social networks) evaluated at 0,16, and 32
weeks post-randomization to test feasibility, acceptability, fidelity of CAPABLE-Transplant and estimate
preliminary effects sizes for a future efficacy trial. To our knowledge, there are no other home-based programs
that address patient-directed goals and the home environment among those inactive awaiting KT. This work
will form the basis for a future R01 to expand to other KT centers and/or into other transplant populations
conducting a larger community-based, efficacy trial.
Terms: <Address><Admission><Admission activity><Affect><Age><American><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Caring><Cohort Studies><Communities><Concurrent Studies><Conditioning Therapy><Development><Dialysis><Dialysis procedure><Disparities><Disparity><ESRD><Education><Educational aspects><Elderly><Elements><Emotional Depression><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Enrollment><Environment><Equity><Evidence based intervention><Fatigue><Funding><Future><Goals><Healthcare><Heterogeneity><Home><Home environment><Hospital Admission><Hospitalization><Individual><Internet><Intervention><Intervention Strategies><Interview><Kidney Grafting><Kidney Transplantation><Kidney Transplants><Lack of Energy><Letters><Low income><Mental Depression><Mentors><Mentorship><Modeling><Nurses><Nursing Homes><Occupational Therapist><Outcome><Pain><Painful><Participant><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Personalized medical approach><Persons><Phase><Physical Function><Population><Procedures><QOL><Quality of life><Randomized><Renal Grafting><Renal Transplantation><Renal Transplants><Reporting><Research><Risk><Self Efficacy><Self Management><Services><Social Network><Social isolation><Social support><Stress><Surgical complication><Symptom Burden><Symptoms><Telemedicine><Time><Training><Transplantation><Voting><Vulnerable Populations><WWW><Waiting Lists><Work><advanced age><age in place><ages><aging in place><alleviate symptom><ameliorating symptom><behavior intervention><behavioral intervention><control trial><death risk><decrease symptom><depression><depression symptom><depressive><depressive symptoms><design><designing><developmental><dialysis therapy><disability><efficacy trial><enroll><evidence base><experience><feasibility testing><fewer symptoms><functional improvement><functional independence><geriatric><health care><health literacy><homes><human centered design><improve function><improved><improved functional outcomes><inadequate health literacy><individualized approach><interventional strategy><kidney tx><low health literacy><member><mortality><mortality risk><multidisciplinary><novel><nurse><nursing home><older adult><older adulthood><open label><open label study><participant interview><patient oriented outcomes><patient portal><personalized approach><pilot test><poor health literacy><precision approach><primary outcome><programs><prospective><prototype><psychosocial><randomisation><randomization><randomly assigned><recruit><reduce symptoms><reduced health literacy><relieves symptoms><senior citizen><social culture><social engagement><social involvement><social participation><social support network><socio-cultural><sociocultural><surgery complication><symptom alleviation><symptom reduction><symptom relief><tailored approach><transplant><transplant centers><transplant model><vulnerable group><vulnerable individual><vulnerable people><waitlist><web><world wide web>