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Principal Investigator: WANDA PHIPATANAKUL
Organization: BOSTON CHILDREN'S HOSPITAL
Fiscal Year: 2020
Award: $301,999
Funding agency: National Institute of Allergy and Infectious Diseases
Project Summary/Abstract
COVID-19, the infectious disease caused by SARS-CoV-2, is rapidly affecting humans around the globe.
While initial epidemiological data have focused on cases that resulted in severe respiratory disease seen
predominantly in adults, little information regarding the infection burden in children is available. This is
complicated by the observation that many virologically-confirmed cases in children are asymptomatic. Home
environments are established sources of exposure that exacerbate symptoms of asthma and home-based
interventions are proven effective. Prior to the inception of the School Inner-City Asthma Study (SICAS-1), no
American study had comprehensively evaluated the relationship between urban exposures in school,
classroom, and home environments and asthma morbidity. Nearly all elementary school children spend 7 to
12 hours a day in school, and most of that time is spent in one classroom. From SICAS-1, we learned that
student classroom-specific mouse allergen, mold, and particulate pollutant exposure is associated with
worsening symptoms. We also demonstrated our ability to reduce these exposures in a busy, school setting.
Our proposal builds upon our established, successful school-based infrastructure to determine whether a
school/classroom intervention will efficiently and effectively improve asthma morbidity by reducing these
exposures. Our goal is to determine the efficacy of school/classroom based environmental intervention in
reducing asthma morbidity in urban schoolchildren. Our central hypothesis is that reducing classroom/school
exposure to mouse allergen, mold, and particulate pollutants will decrease asthma morbidity in students with
asthma. We plan to test this hypothesis in an intervention study of 250 elementary students with asthma from
multiple classrooms in 40 Boston inner-city elementary schools. Our clinical trial aims are to determine the
effectiveness of a school/classroom based environmental intervention (school integrated pest management
and classroom air purifying filter units within these schools) to reduce asthma morbidity. The supplement to
the parent grant is to leverage the cohort for the to participate in the multi-center survey entitled Human
Epidemiology and Response to SARS-CoV-2 (HEROS), study. This study can be rapidly implemented and
realistically conducted without necessitating any visits to a clinical research center. In addition to the need for
surveying children for asymptomatic SARS-CoV-2 infection, this study will allow a comparison between
children with asthma and other atopic conditions and children without those conditions through remote surveys
and collection of samples. This study is an unprecedented, high impact opportunity to leverage the parent trial
with in scope in understanding how SARS-C0V-2 differentially affects children with the condition of interest,
compared to children without it.
Terms: <0-11 years old><2019 novel coronavirus><2019-nCoV><21 year old><21 years of age><21+ years old><Adult><Adult Human><Affect><Air><Allergens><Allergic Disease><American><Asthma><Boston><Bronchial Asthma><COVID-19><COVID19><Care Givers><Caregivers><Child><Child Youth><Children (0-21)><Clinical Research><Clinical Study><Clinical Trials><Communicable Diseases><Data Bases><Databases><Detection><Effectiveness><Enrollment><Epidemiological data><Epidemiology><Epidemiology data><Exposure to><Family><Filamentous Fungi><Funding><Goals><Home><Home environment><Hour><Household><Human><Human Subject Research><Hypersensitivity skin testing><IRB><IRBs><IgE><Immunoglobulin E><Incidence><Infection><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Infrastructure><Institutional Review Boards><Intervention><Intervention Strategies><Intervention Studies><Letters><Lung diseases><Modern Man><Molds><Morbidity><Morbidity - disease rate><NIAID><NIH><Nasal><Nasal Passages Nose><National Institute of Allergy and Infectious Disease><National Institutes of Health><Non-Polyadenylated RNA><Nose><Parents><Participant><Phenotype><Pulmonary Diseases><Pulmonary Disorder><RNA><RNA Gene Products><Research Design><Research Proposals><Respiratory Disease><Respiratory System Disease><Respiratory System Disorder><Respiratory System, Nose, Nasal Passages><Ribonucleic Acid><SARS><SARS coronavirus disease><SARS-CoV disease><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Sampling><Schools><Severe Acute Respiratory Syndrome><Severe Acute Respiratory Syndrome CoV disease><Severe Acute Respiratory Syndrome coronavirus disease><Severe acute respiratory syndrome coronavirus 2><Siblings><Skin Tests><Source><Students><Study Type><Survey Instrument><Surveys><Symptoms><Testing><Time><United States National Institutes of Health><Visit><Wuhan coronavirus><adulthood><age 21><age 21 years><base><burden of infection><children><childrens'><classroom environment><cohort><college atmosphere><collegial atmosphere><collegiate atmosphere><common rule><corona virus disease 2019><coronavirus disease 2019><data base><disease of the lung><disorder of the lung><education atmosphere><educational atmosphere><educational environment><elementary school><enroll><environmental intervention><epidemiologic><epidemiologic data><epidemiological><expectation><grade school><hypersensitivity test><immunologic skin test><improved><indexing><infection burden><inner city><intellectual atmosphere><interest><intervention research><interventional research><interventional strategy><interventional study><interventions research><learning atmosphere><learning environment><lung disorder><mouse allergen><parent grant><particulate pollutant><phenotypic data><primary end point><primary endpoint><prospective><recruit><response><sample collection><school atmosphere><skin allergy><skin hypersensitivity><specimen collection><study design><training atmosphere><twenty-one year old><twenty-one years of age><university atmosphere><viral RNA><viral detection><virology><virus RNA><virus detection><youngster>