Document text
Principal Investigator: GABRIEL Alejandro DE ERAUSQUIN
Organization: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
Fiscal Year: 2024
Award: $502,764
Funding agency: National Institute on Aging
P1 Abstract
The novel coronavirus, SARS-CoV-2, spread worldwide, resulting in devastating consequences. Our
preliminary data and several published studies strongly suggest that, in adults over 60 years of age, post-
infectious cognitive impairment is present in nearly half of affected people, potentially regardless of the severity
of acute COVID-19 illness. Given the already alarming and increasing numbers of persons with Alzheimer's
dementia and related dementias (ADRD) globally, it is essential that we investigate and understand the degree
and manner and in which SARS-CoV-2 may place older persons at higher risk of progressive cognitive decline
and even ADRD. We have put together an international consortium of investigators uniquely poised to collect
and analyze a broad range of high quality clinical, biomarker, genome, and neuroimaging data. The study,
entitled Interaction between SARS-CoV-2 Infection and Ancestral genomic Variations in the Risk of
Alzheimer's Disease (ISAVRAD), proposes a five-site, international, two-arm (patients and controls),
longitudinal (baseline, 18 and 36-months) design enrolling 4,300 individuals with and without history of SARS-
CoV-2. Project 1 of ISAVRAD will describe the longitudinal course, epidemiological risk/resiliency factors, and
environmental interactions predictive of cognitive decline and progress to ADRD following SARS-CoV-2
infection in adults over 60 years of age from ancestral and admixed populations. Specifically, Project 1 will
longitudinally compare the rate of cognitive decline in older adults with and without exposure to SARS-CoV-2
infection (Aim 1). We hypothesize that cognitive changes will be progressive in nature and increase rates of
ADRD based on Clinical Dementia Rating scores and neurocognitive performance. For the infected group, we
will compare outcomes by severity of COVID-19 symptoms and the presence and severity of anosmia, under the
hypothesis that that hyposmia/anosmia, but not acute COVID-19 severity, will predict the presence and
likelihood of progression of cognitive impairment and ADRD (Aim 2). Finally, working with the
Neuroimaging,and Projects 2 and3, we will identify predictors of SARS-CoV-2-induced cognitive decline. We
hypothesize that specific symptoms (anosmia-hyposmia) will segregate with related neuroimaging changes (in
the olfactory cortical network) and risk will be influenced by genetic ancestry to predict the highest risk of
cognitive decline and new onset ADRD (Aim 3).
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><21+ years old><AD dementia><AD related dementia><ADRD><Active Follow-up><Acute><Address><Admission><Admission activity><Admixture><Adult><Adult Human><Affect><African><African American group><African American individual><African American people><African American population><African Americans><Age Years><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Ambulatory Care><Amentia><Amerindian><Anosmia><Biological Function><Biological Markers><Biological Process><COVID disease severity><COVID severity><COVID survivors><COVID-19><COVID-19 disease severity><COVID-19 exposure><COVID-19 infection><COVID-19 infection survivors><COVID-19 severity><COVID-19 survivors><COVID-19 virus><COVID-19 virus infection><COVID19 disease severity><COVID19 infection><COVID19 severity><COVID19 virus><CV-19><Caring><Chicanas><Chicanos><Chronic><Clinical><CoV emergence><CoV-2><CoV2><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complex><Coronavirus Infectious Disease 2019><DNA seq><DNA sequencing><DNAseq><Data><Dementia><Dimensions><Disease><Disorder><Disturbance in cognition><Emotional><Enrollment><Epidemiology><Genetic><Genetic Diversity><Genetic Variation><Genome><Grippe><Guidelines><Hispanic><History><Hospital Admission><Hospitalization><Impaired cognition><Individual><Infection><Influenza><Intensive Care><International><Investigators><Latino Population><Latino group><Latino individual><Latino people><Latinos><Long COVID><Long COVID-19><Long coronavirus disease><Long coronavirus disease 2019><Mechanical ventilation><Medical><Mexican Americans><Moods><Morbidity><Morbidity - disease rate><Native Americans><Natural History><Nature><Neurocognitive><Nigeria><Older Population><Olfactory Cortex><Outcome><Outpatient Care><Patients><Performance><Peripheral><Persons><Phase><Population><Primary Senile Degenerative Dementia><Publishing><Recording of previous events><Recovery><Reporting><Research Personnel><Researchers><Risk><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 disease severity><SARS-CoV-2 exposure><SARS-CoV-2 infection><SARS-CoV-2 severity><SARS-CoV-2 survivors><SARS-CoV2><SARS-CoV2 exposure><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Seroprevalences><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 exposure><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome related corona virus 2><Severities><Site><Symptoms><Syndrome><Texas><Wuhan coronavirus><active followup><acute COVID-19><acute SARS-CoV-2 infection><acute phase of COVID-19><acute phase of SARS-CoV-2 infection><acute symptom><adulthood><after COVID-19 infection><after SARS-CoV-2 infection><after SARS-CoV2 infection><after infection by SARS-CoV-2><after severe acute respiratory distress syndrome CoV-2 infection><alzheimer risk><amnestic mild cognitive impairment><anosphrasia><arm><bio-markers><biologic marker><biomarker><chronic COVID><chronic COVID-19><chronic novel coronavirus disease 2019><cognitive change><cognitive dysfunction><cognitive loss><corona virus emergence><coronavirus disease 2019><coronavirus disease 2019 disease severity><coronavirus disease 2019 exposure><coronavirus disease 2019 infection><coronavirus disease 2019 severity><coronavirus disease 2019 virus><coronavirus disease severity><coronavirus disease-19><coronavirus disease-19 virus><coronavirus emergence><coronavirus infectious disease-19><deep learning><deep learning method><deep learning strategy><design><designing><emergent CoV><emergent corona virus><emergent coronavirus><emerging CoV><emerging corona virus><emerging coronavirus><enroll><entire genome><epidemiologic><epidemiological><exposure to COVID-19><exposure to SARS-CoV-2><exposure to SARS-CoV2><exposure to Severe acute respiratory syndrome coronavirus 2><exposure to coronavirus disease 2019><follow up><follow-up><followed up><following COVID-19 infection><following SARS-CoV-2 infection><following SARS-CoV2 infection><following infection by SARS-CoV-2><following severe acute respiratory distress syndrome CoV-2 infection><followup><full genome><genomic variation><hCoV19><high risk><histories><hyposmia><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><long haul COVID><long haul COVID-19><long haul coronavirus disease><long haul coronavirus disease 2019><long-hauler COVID><long-hauler COVID-19><long-hauler coronavirus disease 2019><long-hauler syndrome><long-term COVID><long-term COVID-19><long-term coronavirus disease><long-term coronavirus disease 2019><long-term sequelae><longitudinal course><longterm COVID><longterm COVID-19><longterm coronavirus disease><longterm coronavirus disease 2019><loss of smell><mechanical respiratory assist><mechanically ventilated><mortality><nCoV><nCoV2><neural imaging><neuro-imaging><neuroimaging><neurological imaging><new CoV><new corona virus><new coronavirus><novel CoV><novel corona virus><novel coronavirus><older adult><older adulthood><older groups><older individuals><older person><olfactory loss><outpatient treatment><persistent COVID-19><post COVID syndrome><post COVID-19 syndrome><post SARS-CoV-2 infection><post acute COVID syndrome><post acute COVID-19><post acute COVID-19 syndrome><post acute SARS-CoV-2><post acute coronavirus disease 2019><post acute coronavirus disease 2019 syndrome><post acute coronavirus disease syndrome><post acute severe acute respiratory syndrome coronavirus 2><post coronavirus disease 2019 syndrome><post coronavirus disease syndrome><post-COVID><post-COVID-19><post-acute phases of COVID-19><post-coronavirus disease 2019><precision medicine><precision-based medicine><previous COVID-19 infection><previous SARS-CoV-2 infection><previous SARS-CoV2 infection><previous severe acute respiratory distress syndrome CoV-2 infection><primary degenerative dementia><prior COVID-19 infection><prior SARS-CoV-2 infection><prior SARS-CoV2 infection><prior severe acute respiratory distress syndrome CoV-2 infection><prolonged COVID-19 symptoms><reduced smell><resilience factor><resiliency factor><segregation><senile dementia of the Alzheimer type><severe acute respiratory syndrome coronavirus 2 disease severity><severe acute respiratory syndrome coronavirus 2 severity><survive COVID-19><survive SARS-CoV-2><whole genome>