Document text
Principal Investigator: VASILIS VASILIOU
Organization: YALE UNIVERSITY
Fiscal Year: 2020
Award: $150,625
Funding agency: National Institute on Alcohol Abuse and Alcoholism
Abstract
The
induces
flu-like
treatment
health,
1,919,430
societal
people
COVID-19.
disease
means
infected
extremely
ventilators,
SARS-CoV-2 . We propose to identify alterations in
the plasma metabolome of patients experiencing different levels of severity of COVID-19. Such changes
should be pivotal in allowing the prediction of the severity of the patient COVID-19 symptoms and also provide
mechanistic information about the disease and its progression. In addition to our expertise in metabolomics, we
are able to carry out this project because we have access to samples from the Yale New Haven Hospital
System via the IMPACT Biorepository. This repository stores human specimens related to emerging
respiratory viral infections (with a particular focus on COVID-19) in order to support research on factors related
to viral expression, transmission, disease severity, progression, and susceptibility. The directors of the
biorepository are co-investigators in this supplement. As such, we are in unique position to perform this novel
research because we have: (a) the infrastructure to conduct the metabolomic analyses and we have already
developed the methodologies, (b) access to COVID-19 patient plasma samples stored at the IMPACT
(Implementing medical and public health actions against coronavirus in Connecticut) Biorepository (and
associated patient records), (c) assembled an extraordinary team that includes expertise in metabolomics,
virology, pulmonary and infectious disease, and immunology.
of this supplement
current pandemic caused by SARS-CoV-2 is of major concern because (i) it is highly contagious, (ii) it
a spectrum of adverse health consequences (collectively known as COVID-19) that range from mild
symptoms (fever, chills, cough) to life-endangering pneumonia and SARS, and (iii) there is no effective
or vaccine to prevent it. To date, the SARS-CoV-2 pandemic has had devastating effects on public
with an international mortality rate of 5.8% in infected individuals. As of June 6, 2020, the U.S. has
cases and a mortality rate of 5.7%. Measures taken to stem the pandemic have paralyzed normal
activities and crippled national and international economies. I n the early stages of the pandemic, older
and individuals with specific underlying medical conditions were shown to be more vulnerable to
More recently, it has become apparent that younger, ostensibly healthy individuals likely carry the
and may succumb/progress to the more serious manifestations of COVID-19. Currently, there is no
to reliably predict the severity of COVID-19 symptoms (or the course of COVID-19) in individuals
by SARS-CoV-2 . This represents a significant knowledge deficit. Having such information would be
helpful in triaging patients and allowing more efficient utilization of limited health resources, e.g.,
ICU beds, and medical personnel. N
or that are associated with the various stages of COVID-19
o studies have investigated metabolic alterations caused by
Terms: <2019 novel coronavirus><2019-nCoV><Alcoholic Liver Diseases><Bacterial/Viral/Mycotic Disease Immunology><Beds><Bilirubin><Bilirubin IX alpha><Biological Markers><Blood Plasma><COVID-19><COVID19><Cardiac><Clinical><Clotting><Coagulation><Coagulation Process><Communicable Diseases><Connecticut><Coronaviridae><Coronavirus><Coughing><D-dimer><D-dimer fibrin><D-dimer fragments><Data><Disease><Disorder><Environmental Health><Environmental Health Science><Family><Female><Ferritin><Fever><Fever Chills><Fibrin fragment D><Funding><Future><Genome><Health><Health Care Providers><Health Personnel><Health Resources><Healthcare Providers><Healthcare worker><Hospitals><Human><Immunology><Individual><Infectious Disease Immunology><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Infrastructure><Inpatients><International><Investigators><Knowledge><Laboratories><Length of Stay><Life><Lung diseases><Machine Learning><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Medical><Metabolic><Methodology><MoAb R24><Modeling><Modern Man><Molecular Fingerprinting><Molecular Profiling><Monoclonal Antibody R24><NIAAA><National Institute on Alcohol Abuse and Alcoholism><Number of Days in Hospital><Out-patients><Outpatients><Palsy><Paralysed><Pathway interactions><Patient Triage><Patients><Plasma><Plasma Serum><Plegia><Pneumonia><Position><Positioning Attribute><Predisposition><Preparation><Prothrombin Time><Prothrombin time assay><Protocol><Protocols documentation><Public Health><Pulmonary Diseases><Pulmonary Disorder><Pyrexia><R-24 Monoclonal Antibody><R24><RNA Viruses><RT-PCR><RTPCR><Records><Research><Research Personnel><Research Specimen><Research Support><Researchers><Respiratory Disease><Respiratory System Disease><Respiratory System Disorder><Reticuloendothelial System, Serum, Plasma><Reverse Transcriptase Polymerase Chain Reaction><SARS><SARS coronavirus disease><SARS-CoV disease><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Safety><Sampling><Severe Acute Respiratory Syndrome><Severe Acute Respiratory Syndrome CoV disease><Severe Acute Respiratory Syndrome coronavirus disease><Severe acute respiratory syndrome coronavirus 2><Severities><Severity of illness><Specimen><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Susceptibility><Symptoms><System><Tissue imaging><Transmission><Triage><Vaccines><Ventilator><Viral><Viral Burden><Viral Load><Viral Load result><Viral Respiratory Tract Infection><Wuhan coronavirus><alcohol induced hepatic injury><alcohol induced liver disorder><alcohol induced liver injury><alcohol-induced hepatic dysfunction><alcohol-induced liver disease><alcohol-induced liver dysfunction><alcohol-mediated liver dysfunction><alcohol-mediated liver injury><alcoholic liver injury><base><bio-markers><biobank><biologic marker><biomarker><biomarker identification><biorepository><corona virus><corona virus disease 2019><coronavirus disease 2019><cytokine><depository><disease of the lung><disease severity><disorder of the lung><effective therapy><effective treatment><ethanol induced hepatic injury><ethanol induced liver disorder><ethanol induced liver injury><ethanol-induced hepatic dysfunction><ethanol-induced liver disease><ethanol-induced liver dysfunction><ethanol-mediated liver dysfunction><ethanol-mediated liver injury><experience><febrile><febris><fibrin fragment D-dimer><fibrin fragment D1 dimer><fibrin fragment DD><flu><health care personnel><health care worker><health provider><health workforce><healthcare personnel><hospital days><hospital length of stay><hospital stay><liver function><lung disorder><machine learned><male><marker identification><medical personnel><metabolism measurement><metabolome><metabolomics><metabolomics resource><metabonome><metabonomics><molecular profile><molecular signature><mortality><novel><pandemic><pandemic disease><paralysis><paralytic><pathway><prevent><preventing><repository><respiratory><reverse transcriptase PCR><statistical analysis><stem><transmission process><treatment provider><viral respiratory infection><virology>