Document text
Principal Investigator: Ryan Lee Minster
Organization: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Fiscal Year: 2024
Award: $1,466,436
Funding agency: National Heart Lung and Blood Institute
SUMMARY/ABSTRACT
Title: Lipidomics and structural genomics of cardiometabolic health in Samoan adults
Project Period: 09/01/2023–08/31/2027
Pacific Islanders, such as Samoans, are disproportionally burdened by cardiometabolic disease yet are un-
derrepresented as participants in health research generally, and in genomics research specifically. In this project
we will expand the knowledge of lipidomic and genetic structural variation present in Samoans to understand the
relationships between the lipidome, simple nucleotide variation, structural genetic, modifiable risk factors, and
cardiometabolic health. In our first aim, we will determine associations between comprehensive serum lipid pro-
files and both simple nucleotide variation and cardiometabolic traits in 4,300 Samoan adults from Samoa and
American Samoa. To achieve this, we will first generate comprehensive lipidomic data, then characterize asso-
ciations between the lipidome, modifiable risk factors, and cardiometabolic phenotypes, conduct lipidome-wide
association studies of known genetic determinants of lipid variation, and perform genome-wide association stud-
ies of the lipidome. In our second aim, we will evaluate associations between structural genetic variation and
both comprehensive lipid profiles and cardiometabolic phenotypes by calling structural variation in 1,285 se-
quenced Samoan adults, imputing that variation into the larger set of the aforementioned 4,300 Samoan adults,
examining associations between structural variation near known genetic determinants of lipidome and cardi-
ometabolic variation, and examining associations between genome-wide structural variation and the lipidome
and cardiometabolic phenotypes. In our third aim, we will conduct exploratory integrative analyses to identify
systems-level patterns among the layers of information available and gathered in the first two aims. Finally, in
our fourth aim, we will propose and lead collaborative investigations of our findings with collaborators among the
TOPMed Program. our active participation with the Program will enlarge the range of multi-ancestry analyses
possible among the participating studies and broaden the impact of this work beyond Samoa. Our discoveries
will improve our understanding of the basic biology of lipids and downstream cardiometabolic health outcomes,
as well as identify potential targets for interventions to improve cardiometabolic health.
Terms: <21+ years old><Address><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><Alcohol Drinking><Alcohol consumption><American><American Samoa><Architecture><Asian Americans><Biological><Biology><Blood Pressure><Blood Serum><Cardiac Diseases><Cardiac Disorders><Cardiac health><Cardiometabolic Disease><Cardiometabolic Disorder><Causality><Cholesterol><Complex><Data><Data Analyses><Data Analysis><Data Set><Dietary Practices><Disease><Disorder><Eastern Samoa><Engineering / Architecture><Environment><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><EtOH drinking><EtOH use><Etiology><Feedback><Funding><GWA study><GWAS><Gene variant><Genes><Genetic><Genetic Determinism><Genetic Diversity><Genetic Variation><Genome><Genomics><Genotype><HDL Cholesterol><HDL Cholesterol Lipoproteins><Health><Heart Diseases><Heart health><High Density Lipoprotein Cholesterol><Individual><Interdisciplinary Research><Interdisciplinary Study><Intervention><Intervention Strategies><Investigation><Ketosis-Resistant Diabetes Mellitus><Knowledge><Lead><Lipids><Maps><Maturity-Onset Diabetes Mellitus><Measurement><Measures><Mendelian randomization><Mission><Molecular><Multidisciplinary Collaboration><Multidisciplinary Research><NHLBI><NIDDM><NIH><National Heart, Lung, and Blood Institute><National Institutes of Health><Native Hawaiian and Other Pacific Islander><Native Hawaiian and Pacific Islander><Native Hawaiian or Other Pacific Islander><Native Hawaiian or Pacific Islander><Navigator Islands><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nucleotides><Obesity><Outcome><Over weight><Overweight><Pacific Islander><Participant><Pattern><Pb element><Persons><Phenotype><Polynesian><Population><Population Heterogeneity><Position><Positioning Attribute><Research><Risk Factors><Samoa><Samoa Islands><Samoan><Samoan Islands><Sampling><Serum><Slow-Onset Diabetes Mellitus><Socio-economic status><Socioeconomic Status><Source><Stable Diabetes Mellitus><System><T2 DM><T2D><T2DM><TOPMed><Testing><Tobacco Consumption><Tobacco use><Trans-Omics for Precision Medicine><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States National Institutes of Health><United States Samoa><Variant><Variation><Voice><Work><adiposity><adult onset diabetes><adulthood><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><allele variant><allelic variant><alpha-Lipoprotein Cholesterol><ancestry analysis><biologic><cardiometabolic><cardiometabolism><causation><co-morbid><co-morbidity><community advisory board><community advisory committee><community advisory panel><community partnership><comorbidity><corpulence><data interpretation><diabetes risk><dietary pattern><disease causation><diverse populations><epidemiologic investigation><epidemiology study><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><experience><fasting glucose><genetic determinant><genetic variant><genome scale><genome wide association><genome wide association scan><genome wide association studies><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association studies><genomewide association study><genomic variant><heart disorder><heavy metal Pb><heavy metal lead><heterogeneous population><high BMI><high body mass index><high risk><improved><insight><interventional strategy><ketosis resistant diabetes><lipidome><lipidomics><lipoprotein triglyceride><malleable risk><maturity onset diabetes><modifiable risk><novel><obesity risk><population diversity><programs><response><risk for obesity><risk of obesity><sedentary><socio-economic position><socioeconomic position><structural genomics><tobacco product use><trait><type 2 DM><type II DM><type two diabetes><whole genome association analysis><whole genome association studies><whole genome association study>