Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy

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Principal Investigator: Ross I. Berbeco
Organization: DANA-FARBER CANCER INST
Fiscal Year: 2024
Award: $566,253
Funding agency: National Cancer Institute

Project Summary
Recent preclinical and clinical results have demonstrated the safety and efficacy of
nanoparticle-amplified radiation therapy. In parallel, MR-guided radiation therapy is an
emerging paradigm that would benefit from specific contrast agents. This Academic-
Industrial Partnership will leverage these current trends by designing, developing and
rigorously testing a novel nanoparticle for MR-guided radiation therapy. Our supporting
data consists of extensive physical and biological characterization of gadolinium and
bismuth-gadolinium based nanoparticles, including in vivo biodistribution, imaging and
therapy results in multiple tumor models. In this project, we will develop and optimize a
direct high-yield synthesis process for bismuth-gadolinium nanoparticles and perform
extensive toxicity and therapy evaluation in a translational model under clinical delivery
schedules and conditions. Our innovative and highly translatable imaging and therapy
concept is compatible with current and emerging clinical practice and could offer a
substantial clinical benefit with minimal patient risk.

Terms: <A549><Aorta><Biodistribution><Biological><Bismuth><Blood Vessels><Brain Neoplasia><Brain Neoplasms><Brain Tumors><Cancer Patient><Cancer Treatment><Chemistry><Clinic><Clinical><Collaborations><Contrast Agent><Contrast Drugs><Contrast Media><DF/HCC><Dana-Farber Cancer Institute><Data><Dedications><Disease><Disorder><Dose><Dose Limiting><Drug Kinetics><Early-Stage Clinical Trials><Environment><Esophagus><Exhibits><Formulation><Gadolinium><Gd element><Goals><Histopathology><Image><Investigators><Lead><Letters><Lung><Lung Neoplasms><Lung Respiratory System><Lung Tumor><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Tumor of the Lung><Malignant neoplasm of lung><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Modeling><NMR Imaging><NMR Tomography><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Normal Tissue><Normal tissue morphology><Nuclear Magnetic Resonance Imaging><Operative Procedures><Operative Surgical Procedures><Organ><Paper><Patient risk><Patients><Pb element><Pharmacokinetics><Phase 1 Clinical Trials><Phase 2 Clinical Trials><Phase I Clinical Trials><Phase II Clinical Trials><Process><Property><Pulmonary Cancer><Pulmonary Neoplasms><Pulmonary malignant Neoplasm><Radiation><Radiation Oncology><Radiation Physics><Radiation therapy><Radiopaque Media><Radiotherapeutics><Radiotherapy><Research Personnel><Researchers><Rodent><Rodentia><Rodents Mammals><Safety><Schedule><Solid Neoplasm><Solid Tumor><Structure><Surgical><Surgical Interventions><Surgical Procedure><Technology><Testing><Therapeutic><Therapy Evaluation><Toxic effect><Toxicities><Translating><Translations><Tumor Tissue><Work><Zeugmatography><anti-cancer therapy><biocompatibility><biologic><biomaterial compatibility><cancer cell><cancer therapy><cancer-directed therapy><clinical practice><clinical relevance><clinical translation><clinically relevant><clinically translatable><contrast enhanced><contrast imaging><design><designing><effective therapy><effective treatment><heavy metal Pb><heavy metal lead><imaging><improved><in vivo><industrial partnership><industry partner><industry partnership><innovate><innovation><innovative><irradiation><lung cancer><lung lesion><nano><nano particle><nano-sized particle><nanoparticle><nanosized particle><non-human primate><nonhuman primate><novel><particle><patient population><phase 1 trial><phase I protocol><phase I trial><phase II protocol><pre-clinical><preclinical><prototype><pulmonary><pulmonary lesion><radiation treatment><scale up><success><surgery><translation><translational model><treatment with radiation><trend><tumor><tumor growth><tumors in the brain><uptake><vascular>