Document text
Principal Investigator: Armando Gil Burgos-Rodriguez
Organization: UNIVERSITY OF PUERTO RICO MED SCIENCES
Fiscal Year: 2024
Award: $2,434,892
Funding agency: NIH Office of the Director
PROJECT SUMMARY/ABSTRACT:
The major goal of this application is to improve and maintain the Caribbean Primate Research Center's (CPRC)
unique research resources through support of operations, administration, veterinary care and research. The
CPRC consists of four integrated facilities: (1) Cayo Santiago Biological Field Station (CSBFS), the most valuable
of the CPRC research resources that holds a colony of free-ranging rhesus brought from India to Cayo Santiago
(CS) in 1938.; (2) the Sabana Seca Field Station (SSFS), the CPRC's headquarters located 10 miles outside of San
Juan that houses rhesus monkeys derived from Cayo Santiago colony in various outdoor configurations for
biomedical and behavioral studies that are not feasible on free-ranging animals; (3) the Laboratory of Virology
and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan which support several research
initiatives using rhesus monkeys as a model; and (4) the Laboratory of Primate Morphology (LPM), which is also
located on the MSC, and houses the CPRC skeletal collections, unique assemblages of nonhuman primate
skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC
is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics,
Behavior and Neurosciences, and Primate Morphology. In 2020, the unprecedented COVID-19 pandemic added
an additional stress to the already tenuous NHP supply by increasing the demand around the world. As a result,
the National Primate Research Centers (NPRC), with the support of NIH/ORIPs, launched an initiative to
establish the NHP Strategic Reserve (NSR). The CPRC served as a pioneer in support of the NSR in several ways.
First, at the onset of the COVID-19 pandemic, the CPRC was able to immediately supply animals to aid COVID-
19 research in the continental US, resulting in numerous high-impact publications. Additionally, in collaboration
with ORIP, underscoring the value of the NIH/ORIP-funded resources, and as a step in the NSR development,
the CPRC proactively engaged in agreements with some NPRCs and supplied high quality animals to expand
their breeding population, as well as to increase their genetic diversity.
Funds are requested in this application to maintain CPRC basic infrastructure of Primate Resources, which are
used to support numerous research projects locally, national and internationally. This grant will also allow CPRC
to continue supporting the Translational Science Initiative (TSI) under the Applied Research Component. A
major strength of this TSI is conducting multidisciplinary collaborative studies to establish and validate NHP
models for preclinical translational projects related to different human diseases.
Terms: <Accreditation><Agreement><Anatomic Sites><Anatomic structures><Anatomy><Animal Experimental Use><Animal Experimentation><Animal Model><Animal Models and Related Studies><Animal Research><Animal Welfare Act><Animals><Applied Research><Applied Science><Area><Behavior><Behavioral Sciences><Biologic Sciences><Biological><Biological Sciences><Biological Warfare><Biomedical Research><Bioscience><Breeding><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CV-19><Caribbean><Caribbean Sea Region><Caribbean region><Caring><Causality><Collaborations><Collection><Communicable Diseases><Communities><Comparative Study><Coronavirus Infectious Disease 2019><Data Bases><Databases><Development><Education><Educational aspects><Etiology><Funding><Genetic><Genetic Diversity><Genetic Variation><Genomics><Goals><Grant><Health><Human><IACUC><India><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Infrastructure><Institutional Animal Care and Use Committee><International><Investigators><Island><Laboratories><Life Sciences><M mulatta><M. mulatta><Macaca mulatta><Medical><Medicine><Metabolic><Minority-Serving Institution><Modeling><Modern Man><Monitor><Morphology><NHLBI><NIAID><NIDCR><NIDR><NIH><NIMH><National Heart, Lung, and Blood Institute><National Institute of Allergy and Infectious Disease><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><National Institute of Mental Health><National Institutes of Health><Neurosciences><Pathologic><Physiologic><Physiological><Plants><Policies><Population><Pre-Clinical Model><Preclinical Models><Primates><Primates Mammals><Provider><Publications><Puerto Rico><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Rhesus><Rhesus Macaque><Rhesus Monkey><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SIV><STLV-1><STLV-I><Science><Scientific Publication><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Simian Immunodeficiency Viruses><Simian T-lymphotropic virus 1><Skeleton><Stress><Structure><Students><Study models><Technology><Training><Translational Research><Translational Science><Type D Oncornaviruses><Type D Oncoviruses><Type D Retrovirus><US Department of Agriculture><USDA><United States Department of Agriculture><United States National Institutes of Health><Universities><Veterinary Medicine><Viral><Virus><West Indies Region><accredited><animal care><animal experimentations><behavior study><behavioral study><biodefense><biologic><biological attack><biowarfare><causation><comparative><computerized><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus infectious disease-19><data base><develop a vaccine><develop vaccines><development of a vaccine><developmental><disease causation><germ free condition><higher education><human disease><improved><intergenerational><minority institution><model of animal><multidisciplinary><non-human primate><nonhuman primate><operation><operations><outreach program><programs><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><simian T lymphotropic virus type I><skeletal><skeletons><specific pathogen free><translation research><translational investigation><type D retrovirus group><undergrad><undergraduate><undergraduate student><vaccine development><virology>