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Principal Investigator: Christian L. Lorson
Organization: UNIVERSITY OF MISSOURI-COLUMBIA
Fiscal Year: 2022
Award: $2,340,729
Funding agency: National Institute of Allergy and Infectious Diseases
The objective of the parent G20 grant is to provide state of the art, highly safe and secure
biocontainment facilities and services to faculty, student and staff researchers at the MU Laboratory for
Infectious Diseases, one of 12 NIH/NIAID Regional Biocontainment Laboratories. The LIDR/MURBL is
currently host to more than 60 researchers. Our research community is successful in grant funding with 14
Principal Investigators currently active in federally and privately funded grants/contracts. The current ABSL3
facility supports aerosol challenge of rodents, but larger animal challenges cannot occur due to a lack of
appropriate containment housing. The goal of this G20 supplement project is to expand the capabilities of
the MURBL to serve the biodefense and emerging infectious disease research for the region. Towards this
objective, we propose to renovate the east suite of the ABSL3, including the installation of a specialized
ante room and effluent decontamination system, to allow for the housing of large animals in biocontainment.
These upgrades would serve the immediate needs of MU faculty of the RBL who are conducting
translational research on SARS-CoV-2, influenza virus, and hepatitis B virus.
Aim 1: Add open caging capabilities to the ABSL3 at LIDR for housing swine and other large animals
following challenge with respiratory viruses that are pathogenic to humans. We propose to build open
caging capacity in the ABSL3 at LIDR for housing up to 10 pigs or other large animals that have been
experimentally infected with various human pathogens. The request includes funds for remodeling in the
anteroom as well as the animal holding room/building effluent system to permit effluent decontamination, and
necessary HVAC upgrades.
Aim 2: Purchase and install equipment for whole animal imaging following infection. We propose to add
capabilities for whole animal imaging, which will allow for reduction of research animals used at LIDR.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Aerosols><Animal Experimental Use><Animal Experimentation><Animal Research><Animals><COVID-19 virus><COVID19 virus><CoV-2><CoV2><Communities><Containment><Contracting Opportunities><Contracts><Decontamination><Emerging Communicable Diseases><Emerging Infectious Diseases><Equipment><Faculty><Family suidae><Funding><Goals><Grant><HBV><Hepatitis B Virus><Homologous Serum Hepatitis Virus><Housing><Human><Infection><Infectious Diseases / Laboratory><Infectious Diseases Research><Influenza Virus><Investigators><Laboratories><Missouri><Modern Man><NIAID><NIH><National Institute of Allergy and Infectious Disease><National Institutes of Health><Parents><Pigs><Principal Investigator><Research><Research Personnel><Researchers><Rodent><Rodentia><Rodents Mammals><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Secure><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Students><Suidae><Swine><System><Translational Research><Translational Science><United States National Institutes of Health><Universities><Wuhan coronavirus><biocontainment facility><biodefense><coronavirus disease 2019 virus><coronavirus disease-19 virus><hCoV19><human pathogen><influenzavirus><nCoV2><pathogenic virus><porcine><research facility><respiratory virus><suid><translation research><viral pathogen><virus pathogen><whole animal imaging>