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Principal Investigator: Dustin T Duncan
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
Fiscal Year: 2024
Award: $774,324
Funding agency: National Heart Lung and Blood Institute
PROJECT SUMMARY To address the aims of the proposed research and RFA-HL-21-018, we will use a syndemics and multi-level approach to investigate relationships between sleep and HIV treatment outcomes and behaviors (e.g., viral suppression and retention in care) cross-sectionally and longitudinally among young people impacted by HIV followed over one year to inform interventions. We will enroll 250 men from the NIH-funded Neighborhoods and Networks (N2) Cohort Study in the proposed N2 Sleep Health Study to address the aims of the research. Eligibility requirements include HIV-seropositive and self-reported willingness to wear a wrist actigraph for 2 weeks at three points over the course of a year. In this longitudinal study, after completing the initial 2-week wrist actigraphy protocol, participants will carry the wrist actigraph for an additional 2 weeks every six months over the one-year study period—for a total of three times. Objectively measured sleep data at baseline could potentially influence decision-making regarding HIV treatment (e.g., antiretroviral treatment [ART] outcomes) over time, providing a clear temporal ordering and an ability to consider potential time-lags. Multi-level factors – e.g., individual-level obesity, intimate partner violence, and spatial proximity to healthcare services – may modify these relationships. The proposed study will be the first objective sleep health study among any population of men. Findings from the proposed research have significant implications for targeting contextually appropriate sleep and HIV interventions as there is a need for new approaches to inform the next generation of HIV interventions (i.e., long-acting injectables).
Terms: <AIDS Virus><AIDS/HIV><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Follow-up><Address><Adherence><Affect><Anti-HIV Positivity><Application Context><BMI><BMI percentile><BMI z-score><Behavior><Bi-sexual><Bisexual><Black><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Body mass index><Caring><Chicago><Clinical><Cohort Studies><Complex><Concurrent Studies><Continuity of Care><Continuity of Patient Care><Continuum of Care><Counseling><Data><Decision Making><Dedications><Disparities><Disparity><Eligibility><Eligibility Determination><Enrollment><Epidemic><Epidemiology><Funding><Gays><General Population><General Public><HIV><HIV Infections><HIV Positive><HIV Positivity><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV/AIDS><HTLV-III Infections><HTLV-III Seroconversion><HTLV-III Seropositivity><HTLV-III-LAV Infections><Health Inequity><Health Services><Housing><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Incidence><Individual><Inequalities in Health><Inequities in Health><Injectable><Intervention><Intervention Strategies><LAV-HTLV-III><Link><Longitudinal Studies><Lymphadenopathy-Associated Virus><Measures><Mental Health><Mental Hygiene><Methodology><NIH><National Institutes of Health><Neighborhoods><Obesity><Outcome><Participant><Patient Self-Report><Persons><Polysomnography><Population><Prevention><Prospective, cohort study><Protocol><Protocol Screening><Protocols documentation><Psychological Health><Quetelet index><Research><Sampling><Self-Report><Sleep><Sleep Disorders><Sleep Monitoring><Social Environment><Social Network><Somnography><Time><Translations><Transmission><Treatment outcome><United States><United States National Institutes of Health><Viral><Viral Burden><Viral Load><Viral Load result><Virus-HIV><Visit><Wrist><actigraph><actigraphy><active followup><adiposity><antiretroviral therapy><antiretroviral treatment><care outcomes><co-morbid><co-morbidity><cohort><community violence><comorbidity><contextual factors><corpulence><drug adherence><drug compliance><enroll><epidemiologic><epidemiological><experience><follow up><follow-up><followed up><followup><health care outcomes><health care service><health determinants><health inequalities><healthcare outcomes><healthcare service><improved><innovate><innovation><innovative><interventional strategy><intimate partner violence><long-term study><longitudinal outcome studies><longterm study><marginalization><marginalized group><marginalized individual><marginalized people><marginalized population><medication adherence><medication compliance><multidisciplinary><neighborhood violence><new approaches><next generation><novel approaches><novel strategies><novel strategy><nutrition><polysomnographic><poor sleep><primary outcome><quality of sleep><racial minority group><racial minority individual><racial minority people><racial minority population><secondary outcome><sexual minority group><sexual minority individual><sexual minority men><sexual minority people><sexual minority population><skills><sleep diseases><sleep dysfunction><sleep health><sleep hygiene><sleep illness><sleep measurement><sleep polysomnography><sleep problem><sleep quality><social climate><social context><social epidemiology><social stigma><socioenvironment><socioenvironmental><stigma><substance use><substance use treatment><substance using><success><syndemic><synergistic epidemic><therapy adherence><therapy compliance><trait><translation><transmission process><treatment adherence><treatment compliance><violence against communities><willingness>