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Principal Investigator: DANIEL R BROOKS
Organization: RESEARCH TRIANGLE INSTITUTE
Fiscal Year: 2024
Award: $1,143,873
Funding agency: National Institute of Diabetes and Digestive and Kidney Diseases
PROJECT SUMMARY/ABSTRACT
A growing number of geographically diverse regions around the world report increasing rates of chronic kidney
disease of uncertain or unknown etiology (CKDu), a life-threatening condition not attributable to traditional
chronic kidney disease risk factors. Yet, the etiology of CKDu remains unclear and data are lacking on CKDu
progression, biological manifestations, genetic determinants, and risk factors that may explain regional
variations. To address these challenges, the National Institutes of Health has formed the Chronic Kidney
Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium. The
Consortium will develop a harmonized study protocol that can be implemented in multiple endemic regions to
understand the etiologies of CKDu and disease progression and to identify potential therapeutic targets and
public health interventions. RTI International and Boston University along with our partners from Harvard
University, National Autonomous University of Nicaragua, University of Colorado, and Stanford University,
propose to establish the CURE Research Consortium Scientific Data Coordinating Center (SDCC). The SDCC
will provide the leadership, infrastructure, and tools to unite the Field Epidemiology Sites, Renal Science Core,
Human Health Exposure Analysis Resource, and NIH into a cohesive whole by promoting consensus building
and collaborative decision making. The SDCC's role in cultivating a common research agenda is crucial to the
CURE Research Consortium's ability to implement ethical epidemiology research designs; common
approaches for data collection, and biological and environmental assessments; best practices for data analysis
and dissemination; and ancillary research studies. Specifically, the SDCC will support the Research
Consortium by accomplishing the following aims: (1) elucidate the likely multifactorial etiologies of CKDu
development and progression in endemic regions by integrating a classic case-control study with longitudinal
assessments of cases to assess factors for disease progression and controls to capture CKDu development;
(2) promote consensus building and foster collaboration and coordination by providing scientific leadership,
expertise in data science and robust analytical methods, and communication, logistical, and operational
support; and (3) enhance Consortium research efficiency, productivity, and scientific rigor by providing sound
study monitoring and oversight and establishing efficient data and specimen management systems using
relevant technology and data visualization tools. Together with a multidisciplinary team of Co-investigators, the
SDCC multiple PIs, Jill Lebov, PhD (contact PI), Marie Gantz, PhD, and Daniel Brooks, PhD, bring the
required scientific and organizational capabilities in Consortium coordination, project management,
epidemiology, biostatistics, data science, nephrology and kidney disease research, environmental and
occupational health, genetics, and ethical conduct of international research in resource-limited settings to
effectively manage the activities of the SDCC, the CURE Research Consortium, and the CURE Study.
Terms: <Active Follow-up><Address><Affect><Agreement><Asia><Behavioral><Biological><Biological Markers><Biometrics><Biometry><Biopsy Sample><Biopsy Specimen><Biostatistics><Boston><Case-Base Studies><Case-Comparison Studies><Case-Compeer Studies><Case-Referent Studies><Case-Referrent Studies><Case/Control Studies><Causality><Central America><Central Asia><Ceylon><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Clinical Treatment><Collaborations><Colorado><Communication><Communities><Consensus><Coordination and Collaboration><Data><Data Analyses><Data Analysis><Data Collection><Data Coordinating Center><Data Coordination Center><Data Reporting><Data Science><Decision Making><Development><Diabetes Mellitus><Disease><Disease Progression><Disorder><Doctor of Philosophy><Ecologic Monitoring><Ecological Monitoring><El Salvador><Eligibility><Eligibility Determination><Enrollment><Ensure><Environmental Factor><Environmental Health><Environmental Health Science><Environmental Monitoring><Environmental Pollutants><Environmental Risk Factor><Epidemiologic Research><Epidemiologic Research Design><Epidemiologic Studies><Epidemiological Research Design><Epidemiological Studies><Epidemiologist><Epidemiology><Epidemiology Research><Equipment><Ethics><Etiology><Family><Fostering><Generations><Genetic><Genetic Determinism><Geography><Health><Health Care Systems><Healthcare Systems><History><Human><Hypertension><India><Individual><Infection><Infrastructure><International><Intervention><Intervention Strategies><Investigators><Kidney><Kidney Diseases><Kidney Urinary System><Laboratories><Lead><Leadership><Life><Longitudinal Studies><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Management Information Systems><Manuals><Medical><Modern Man><Monitor><Morbidity><Morbidity - disease rate><NIH><National Institutes of Health><Nephrology><Nephropathy><Nicaragua><Occupational><Occupational Health><Outcome><Pathway interactions><Patients><Pb element><Ph.D.><PhD><Policies><Principal Investigator><Privatization><Procedures><Productivity><Protocol><Protocol Screening><Protocols documentation><Questionnaires><Recording of previous events><Renal Disease><Reporting><Research><Research Design><Research Personnel><Research Resources><Research Specimen><Research Support><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Risk><Risk Factors><Risk Reduction><Role><Science><Services><Shipping><Site><Specific qualifier value><Specified><Specimen><Sri Lanka><Study Type><System><Technology><Training><United States National Institutes of Health><Universities><Variant><Variation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Visualization software><Work><active followup><agricultural community><analytical method><bio-markers><biobank><biologic><biologic marker><biomarker><biorepository><case control><case-controlled><case-controlled studies><causation><chronic kidney disease><cohort><community research><data dissemination><data interpretation><data management and coordinating center><data management center><data representation><data representations><data tools><data visualization><developmental><diabetes><disease causation><disease control><disorder control><electronic data capture system><enroll><environmental contaminant><environmental risk><environmental testing><epidemiologic><epidemiologic investigation><epidemiological><epidemiology study><ethical><experience><follow up><follow-up><followed up><followup><genetic determinant><heavy metal Pb><heavy metal lead><high blood pressure><histories><human subject protection><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><interest><interventional strategy><kidney biopsy><kidney disorder><kidney dysfunction><local economy><long-term study><longitudinal outcome studies><longterm study><meeting><meetings><men><mortality><multidisciplinary><novel><pathway><programs><public health intervention><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><renal><renal biopsy><renal disorder><renal dysfunction><research study><research vision><risk-reducing><sample collection><social role><sound><specimen collection><study design><therapeutic target><tool><trial regimen><trial treatment><visualization tool><web site><website>