Document text
Principal Investigator: ELLEN L BURNHAM
Organization: UNIVERSITY OF COLORADO DENVER
Fiscal Year: 2022
Award: $96,728
Funding agency: National Institute on Alcohol Abuse and Alcoholism
Project Summary
The proposed supplement will augment an established R24 Alcohol Research Resource, known as CoPARC
(Colorado Pulmonary-Alcohol Research Collaborative), that has served as a human participant and patient
biorepository supporting translational investigations at the intersection of alcohol misuse and pulmonary
disease. CoPARC is centered at the University of Colorado, and has contributed to the research programs of
established and junior investigators since 2011. Current CoPARC activities involve collection, processing, and
assays in human respiratory biospecimens. This poses an increased risk for contracting the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To address this issue, modifications to CoPARC's
existing infrastructure are necessary to continue active collaborations. Further, extending approved research
protocols to conduct investigations delineating alcohol's role in the pathogenesis of Coronavirus Disease
(COVID)-19-associated respiratory failure and the acute respiratory distress syndrome (ARDS) are planned,
and CoPARC's co-investigators have expressed unanimous support for expanded research in this area. Early
reports in patients with COVID-19-associated respiratory failure and ARDS suggest that aberrations in the
immune response influence severity of illness, contributing to multi-organ dysfunction and death. Importantly,
harmful alcohol use has been associated with dysregulated pulmonary immunity and alveolar-capillary
permeability that may explain its consistent association with severe ARDS. Nevertheless, the relationship
between alcohol use and SARS-CoV-2-related respiratory illness remains unknown. This supplement will
complement CoPARC's mission by enabling studies to delineate the impact of alcohol use on infection due to
SARS-CoV-2, including the role of alcohol use on short- and long-term outcomes in respiratory failure and
ARDS. Approximately 25% of patients hospitalized with severe COVID-19 at CoPARC's principal clinical site,
the University of Colorado Hospital, endorse regular alcohol use, and alcohol misuse appears to be increasing
across the US during the pandemic. Therefore, the role of alcohol consumption in COVID-19 disease
pathogenesis warrants additional investigation. Aims for this supplement are in line with the NIAAA's notice of
special interest to meet urgent research needs to further knowledge regarding how alcohol-associated organ
damage may complicate health outcomes in COVID-19, and include: (1) Adapt the existing CoPARC
infrastructure to safely and efficiently perform translational pulmonary investigations to understand the role of
alcohol use on SARS-CoV-2 infection, and its impact on short-term (i.e. 28 day) outcomes among hospitalized
in-patients with COVID-19-related respiratory failure and ARDS; and (2) In a cohort of ICU survivors, with and
without COVID-19-associated respiratory failure and ARDS, who are recruited for CoPARC investigations,
perform longitudinal follow up for six months following hospital discharge, including detailed alcohol use
measures and objective assessments of respiratory health.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><ARDS><Active Follow-up><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Address><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><Airway health><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Alveolar><Ambulatory Care Facilities><Area><Assay><Authorization><Authorization documentation><Bioassay><Biologic Assays><Biological Assay><Biological Markers><Blood Sample><Blood specimen><Bronchoscopy><COVID><COVID associated ARDS><COVID associated acute respiratory distress syndrome><COVID crisis><COVID epidemic><COVID induced ARDS><COVID induced acute respiratory distress syndrome><COVID infected patient><COVID pandemic><COVID patient><COVID positive patient><COVID related ARDS><COVID related acute respiratory distress syndrome><COVID-19><COVID-19 antibody><COVID-19 associated ARDS><COVID-19 associated acute respiratory distress syndrome><COVID-19 crisis><COVID-19 epidemic><COVID-19 exposure><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 induced ARDS><COVID-19 induced acute respiratory distress syndrome><COVID-19 infected patient><COVID-19 infection><COVID-19 pandemic><COVID-19 pathogenesis><COVID-19 patient><COVID-19 positive patient><COVID-19 public health crisis><COVID-19 related ARDS><COVID-19 related acute respiratory distress syndrome><COVID-19 related risk><COVID-19 risk><COVID-19 risk factor><COVID-19 virus><COVID-19/ARDS><COVID-19/acute respiratory distress syndrome><COVID/ARDS><COVID/acute respiratory distress syndrome><COVID19><COVID19 associated ARDS><COVID19 associated acute respiratory distress syndrome><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 induced ARDS><COVID19 induced acute respiratory distress syndrome><COVID19 infection><COVID19 pandemic><COVID19 pathogenesis><COVID19 patient><COVID19 positive patient><COVID19 public health crisis><COVID19 related ARDS><COVID19 related acute respiratory distress syndrome><COVID19 virus><COVID19/ARDS><COVID19/acute respiratory distress syndrome><CV-19><CV19><Capillary Permeability><Cessation of life><Clinic><Clinic Visits><CoV disease><CoV-2><CoV2><Collaborations><Collection><Colorado><Communities><Complement><Complement Proteins><Contracting Opportunities><Contracts><Da Nang Lung><Death><Development><Disease><Disorder><Dysfunction><Enrollment><EtOH drinking><EtOH use><Evaluation><Faculty><Feces><Functional disorder><Funding><Habits><Health><Health Care Providers><Health Personnel><Healthcare Providers><Healthcare worker><High Resolution Computed Tomography><Hospitals><Human><Immune response><Immunity><Immunological response><Infection><Infrastructure><Intensive Care Units><Investigation><Investigators><Knowledge><Laboratory Personnel><Letters><Link><Lung><Lung Function Tests><Lung Respiratory System><Lung diseases><Measures><Mechanical ventilation><Mission><MoAb R24><Modern Man><Modification><Monoclonal Antibody R24><NIAAA><Nasal><Nasal Passages Nose><National Institute on Alcohol Abuse and Alcoholism><Nose><Organ><Outcome><Outpatient Clinics><Participant><Pathogenesis><Pathway interactions><Patients><Performance><Permission><Physiopathology><Pneumonia><Procedures><Process><Protocol><Protocols documentation><Provider><Pulmonary Diseases><Pulmonary Disorder><Pulmonary function tests><R-24 Monoclonal Antibody><R24><Regulation><Reporting><Research><Research Activity><Research Infrastructure><Research Personnel><Research Resources><Researchers><Resources><Respiratory Failure><Respiratory System, Nose, Nasal Passages><Risk><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 antibody><SARS-CoV-2 associated ARDS><SARS-CoV-2 associated acute respiratory distress syndrome><SARS-CoV-2 epidemic><SARS-CoV-2 exposure><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 induced ARDS><SARS-CoV-2 induced acute respiratory distress syndrome><SARS-CoV-2 infected patient><SARS-CoV-2 infection><SARS-CoV-2 pandemic><SARS-CoV-2 patient><SARS-CoV-2 positive patient><SARS-CoV-2 related ARDS><SARS-CoV-2 related acute respiratory distress syndrome><SARS-CoV-2/ARDS><SARS-CoV-2/acute respiratory distress syndrome><SARS-CoV2><SARS-CoV2 antibody><SARS-CoV2 epidemic><SARS-CoV2 exposure><SARS-CoV2 infection><SARS-CoV2 pandemic><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 exposure><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome related corona virus 2><Severities><Severity of illness><Shock Lung><Stiff lung><Survivors><Time><Universities><Update><Wuhan coronavirus><active followup><alcohol effect><alcohol ingestion><alcohol intake><alcohol misuse><alcohol product use><alcohol related research><alcohol research><alcohol use><alcoholic beverage consumption><alcoholic drink intake><antibody against COVID-19><antibody against SARS-CoV-2><antibody against SARS-CoV2><antibody against coronavirus disease 2019><antibody against severe acute respiratory syndrome coronavirus 2><antibody to COVID-19><antibody to SARS-CoV-2><antibody to SARS-CoV2><antibody to coronavirus disease 2019><antibody to severe acute respiratory syndrome coronavirus 2><bio-markers><biobank><biologic marker><biomarker><biorepository><chest CT><chest computed tomography><clinical research site><clinical site><cohort><corona virus disease><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease><coronavirus disease 2019><coronavirus disease 2019 antibody><coronavirus disease 2019 associated ARDS><coronavirus disease 2019 associated acute respiratory distress syndrome><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 exposure><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 induced ARDS><coronavirus disease 2019 induced acute respiratory distress syndrome><coronavirus disease 2019 infected patient><coronavirus disease 2019 infection><coronavirus disease 2019 pandemic><coronavirus disease 2019 pathogenesis><coronavirus disease 2019 patient><coronavirus disease 2019 positive patient><coronavirus disease 2019 public health crisis><coronavirus disease 2019 related ARDS><coronavirus disease 2019 related acute respiratory distress syndrome><coronavirus disease 2019 risk><coronavirus disease 2019 risk factor><coronavirus disease 2019 virus><coronavirus disease 2019/ARDS><coronavirus disease 2019/acute respiratory distress syndrome><coronavirus disease associated ARDS><coronavirus disease associated acute respiratory distress syndrome><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease induced ARDS><coronavirus disease induced acute respiratory distress syndrome><coronavirus disease infected patient><coronavirus disease pandemic><coronavirus disease patient><coronavirus disease positive patient><coronavirus disease related ARDS><coronavirus disease related acute respiratory distress syndrome><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 pathogenesis><coronavirus disease-19 patient><coronavirus disease-19 virus><coronavirus disease/ARDS><coronavirus disease/acute respiratory distress syndrome><coronavirus infectious disease-19><coronavirus patient><developmental><disease of the lung><disease severity><disorder of the lung><enroll><ethanol consumption><ethanol drinking><ethanol effect><ethanol ingestion><ethanol intake><ethanol misuse><ethanol product use><ethanol research><ethanol use><exposure to COVID-19><exposure to SARS-CoV-2><exposure to SARS-CoV2><exposure to Severe acute respiratory syndrome coronavirus 2><exposure to coronavirus disease 2019><follow up><follow-up><followed up><followup><hCoV19><health care personnel><health care worker><health provider><health related quality of life><health workforce><healthcare personnel><high resolution CT><host response><immune system response><immunoresponse><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><interest><life-threatening COVID><life-threatening COVID-19><life-threatening SARS-CoV-2><life-threatening coronavirus disease><life-threatening coronavirus disease 2019><life-threatening severe acute respiratory syndrome coronavirus 2><lung disorder><lung failure><lung health><mechanical respiratory assist><mechanically ventilated><medical personnel><member><mortality><nCoV2><novel><pandemic><pandemic disease><pathophysiology><pathway><patient infected with COVID><patient infected with COVID-19><patient infected with SARS-CoV-2><patient infected with coronavirus disease><patient infected with coronavirus disease 2019><patient infected with severe acute respiratory syndrome coronavirus 2><patient with COVID><patient with COVID-19><patient with COVID19><patient with SARS-CoV-2><patient with coronavirus disease><patient with coronavirus disease 2019><patient with severe acute respiratory distress syndrome coronavirus 2><programs><pulmonary><pulmonary failure><pulmonary health><pulmonary symptom><recruit><respiratory><respiratory health><risk associated with COVID-19><risk factor associated with COVID-19><risk factor related to COVID-19><risk related to COVID-19><serious COVID><serious COVID-19><serious SARS-CoV-2><serious coronavirus disease><serious coronavirus disease 2019><serious severe acute respiratory syndrome coronavirus 2><severe COVID><severe COVID-19><severe COVID19><severe SARS-CoV-2><severe acute respiratory syndrome coronavirus 2 antibody><severe acute respiratory syndrome coronavirus 2 associated ARDS><severe acute respiratory syndrome coronavirus 2 associated acute respiratory distress syndrome><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 induced ARDS><severe acute respiratory syndrome coronavirus 2 induced acute respiratory distress syndrome><severe acute respiratory syndrome coronavirus 2 infected patient><severe acute respiratory syndrome coronavirus 2 patient><severe acute respiratory syndrome coronavirus 2 positive patient><severe acute respiratory syndrome coronavirus 2 related ARDS><severe acute respiratory syndrome coronavirus 2 related acute respiratory distress syndrome><severe acute respiratory syndrome coronavirus 2/ARDS><severe acute respiratory syndrome coronavirus 2/acute respiratory distress syndrome><severe coronavirus disease><severe coronavirus disease 19><severe coronavirus disease 2019><severe severe acute respiratory syndrome coronavirus 2><social role><stool><substance use><substance using><treatment provider><unhealthy alcohol use><virtual health><wet lung>