Preclinical Evaluation of Radioprotectin-1 for Mitigation of GI-ARS
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Principal Investigator: France Carrier Organization: UNIVERSITY OF MARYLAND BALTIMORE Fiscal Year: 2023 Award: $23,254 Funding agency: National Institute of Allergy and Infectious Diseases Project Abstract Project Abstract has not changed from original submission Terms: <AKT><Acceleration><Acute Radiation Syndrome><Agonist><Akt protein><Apoptotic><Assay><Benzoic Acids><Bioassay><Biologic Assays><Biological Assay><Blood Precursor Cell><Bone Marrow><Bone Marrow Reticuloendothelial System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Survival><Cell Viability><Cells><Cessation of life><Collaborations><Colon><Complex><DNA Damage Repair><DNA Integration><DNA Repair><Death><Development><Dose><Drug Formulations><Drug Kinetics><Drug Targeting><Drugs><ERK 1><ERK1><ERK1 Kinase><Enzyme Gene><Enzymes><Evaluation><Extracellular Signal-Regulated Kinase 1><Formulation><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Generations><Genes><Genotoxic Stress><Growth Agents><Growth Factor><Growth Substances><Gut Epithelium><Hematopoietic><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Human><Immunoglobulin Enhancer-Binding Protein><Induction of Apoptosis><Inhibition of Apoptosis><Injury><Intestinal><Intestines><Intracellular Communication and Signaling><Investigational Drugs><Investigational New Drugs><LD-50><LD50><LPA Receptors><Laboratories><Lethal Dose 50><Leucine-Rich Repeat><Lysophosphatidic Acid Receptors><M mulatta><M. mulatta><MAP Kinase 3><MAPK3><MAPK3 Mitogen-Activated Protein Kinase><MAPK3 gene><MOPA><Macaca mulatta><Mediating><Medication><Mice><Mice Mammals><Mitogen-Activated Protein Kinase 3><Mitogen-Activated Protein Kinase 3 Gene><Modeling><Modern Man><Molecular Mechanisms of Action><Murine><Mus><NF-kB><NF-kappa B><NF-kappaB><NFKB><Natural regeneration><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Organ><P44ERK1><PSTkinase p44mpk><Pathology><Pathway interactions><Pharmaceutic Preparations><Pharmaceutical Preparations><Pharmacies><Pharmacokinetics><Pharmacy facility><Phosphoprotein Phosphatase><Phosphoprotein Phosphatase-2C><Phosphoprotein Phosphohydrolase><Progenitor Cells><Property><Protein Kinase B><Protein Phosphatase C><Protein Phosphatase Gene><Protein Phosphatase-1><Protein Phosphatase-2A><Protein phosphatase><Proteins Growth Factors><Proto-Oncogene Proteins c-akt><RAC-PK protein><Radiation><Radiation Dose><Radiation Dose Unit><Radiation Induced DNA Damage><Radiation Induced Genotoxicity><Radiation Protection><Radiation Toxicity><Radiation induced damage><Radioprotection><Radioprotective><Radiotoxicity><Receptor Protein><Regeneration><Rhesus Macaque><Rhesus Monkey><Right-Handed Beta-Alpha Superhelix><Signal Transduction><Signal Transduction Systems><Signaling><Testing><Therapeutic><Toxicokinetics><Transcription Factor NF-kB><Unscheduled DNA Synthesis><analog><biological signal transduction><blood stem cell><bowel><c-akt protein><cell regeneration><cellular regeneration><cellular targeting><college><collegiate><developmental><drug candidate><drug development><drug discovery><drug/agent><efficacy study><experience><gastrointestinal><gastrointestinal epithelium><gene product><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><in vivo><injuries><irradiation><kappa B Enhancer Binding Protein><lipid mediator><lysophosphatidic acid><monooleylphosphatidate><monooleylphosphatidic acid><mortality><nano particle><nano-sized particle><nanoparticle><nanoparticle drug><nanosized particle><non-human primate><nonhuman primate><nuclear factor kappa beta><p44 MAPK><pathway><pre-clinical evaluation><preclinical evaluation><prevent><preventing><progenitor cell survival><programs><proto-oncogene protein RAC><proto-oncogene protein akt><rac protein kinase><radiation countermeasure><radiation damage><radiation damage to DNA><radiation mitigation><radiation mitigator><radiation poisoning><radiation-induced DNA breaks><radio-protection><radio-protective><radiological countermeasure><radiological mitigation><radiological mitigator><radiomitigation><radiomitigator><receptor><recruit><regenerate><regenerative><related to A and C-protein><senescence><senescent><small molecule><stem cell survival><stem cells>